Two Antifungal Xanthones from the Heartwood of Calophyllum Symingtonianum

Kawamura, Fumio; Muhamud, Amalia; Hashim, Rokiah; Sulaiman, Othman; Ohara, Seiji

doi:10.6090/jarq.46.181

Cited by 17 publications

(5 citation statements)

References 19 publications

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“…Calophyllum symingtonianum, known as "bintangor bukit" is one of the Calophyllum species found in the Malay Peninsula. It usually grows in forest hills at an altitude of 100-150 m (Kawamura et al, 2012) and have evergreen broad-leaved tree.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

et al. 2016

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Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 µg/mL and A-549 at 26.41µg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125µg/mL and 62.5µg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

et al. 2016

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“…In 2012, Kawamura et al [39] extracted the heartwood of Calophyllum symingtonianum with ethyl acetate and n-hexane and successfully isolated two xanthones, 1,3,5-trihydroxy-2-(3methylbut-2-enyl) xanthone (88) and 6-desoxyjacareubin (89) respectively. These xanthones were identified by comparison of the 1 H nuclear magnetic resonance ( 1 H NMR) spectra and electron impact mass (EIMS) spectra.…”

Section: Calophyllum Symingtonianummentioning

confidence: 99%

“…In 2012, Kawamura et al [39] . extracted the heartwood of Calophyllum symingtonianum with ethyl acetate and n‐hexane and successfully isolated two xanthones, 1,3,5‐trihydroxy‐2‐(3‐methylbut‐2‐enyl) xanthone ( 88 ) and 6‐desoxyjacareubin ( 89 ) respectively.…”

Section: Xanthone From Calophyllum Speciesmentioning

confidence: 99%

Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis

Heilman,

Hui,

Mian

et al. 2023

ChemistrySelect

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Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern, driven a need to discover and evaluate novel anti‐bacterial agents. Calophyllum species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti‐bacterial properties that are effective against plant pathogens, hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from Calophyllum and its anti‐bacterial were discussed in this review. Besides, molecular docking simulations were applied to explore the potential binding mode of xanthones to DNA metabolism enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their co‐cystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti‐bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti‐microbial activity of xanthone contributes from the topoisomerase enzyme‘s inhibition.

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“…It contains xanthones, coumarins, biflavonoids, chalcones, benzofurans and triterpenes. It have antioxidant, anti fungal [62] and anti human immunodeficiency virus activities.…”

Section: Medicinal Plants Used For the Screening Of Antimicrobial Act...mentioning

confidence: 99%

A Review on Malaysian Plants Used for Screening of Antimicrobial Activity

Mohammed

Vikram

Chiruvella

et al. 2014

ARRB

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This work was carried out in collaboration between all authors. Author MA initiated the idea of writing this review article, supervised, made all the alignments, corrections and proof reading to the script, author PV studied and drafted most of article, Author KKC drafted the antimicrobial methods part and table, Author MMS helped in tabulating the entire data for table 1 and Author IHBAR helped in data collection and reference management. All authors read and approved the final manuscript.

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Two Antifungal Xanthones from the Heartwood of Calophyllum Symingtonianum

Cited by 17 publications

References 19 publications

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis

A Review on Malaysian Plants Used for Screening of Antimicrobial Activity

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