Two Annular Alopecic Lesions on the Scalp in a Young Asian Man: A Quiz

Park, Sukyung; Kwak, Hyun-Bin; Yun, Seok-Kweon; Kim, Han-Uk; Jin, Peng

doi:10.2340/00015555-2556

Cited by 8 publications

(6 citation statements)

References 7 publications

(9 reference statements)

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“…Among patients with lupus panniculitis, 5 presented linear alopecia. 8,22,27,28,30 Follicular plugging was noted in four cases (our case and previous studies), 14,29,35 sclerosis in three 13,19,35 and milia in one. 25 Patients were mostly asymptomatic but pruritis was occasionally noted.…”

Section: Discussionsupporting

confidence: 76%

“…3,8 13 1 1 (100) --AZA c, 15 1 1 (100) --Antimalarial and dapsone b,c, 31 1 1 (100) --2. Antimalarial with 19 12 (63) 6 (32) 1 (5) In monotherapy 10,11,23,26 4 3 (75) 1 (25) -Topical corticosteroids 8,14,19,28,35 5 4 (80) 1 (20) -TCI (our case and previous studies) 3 4 -4 (100) -Topical corticosteroids and TCI (our case and previous studies) 34 6 1 1 (100) --Topical anti-inflammatory 6 1 1 (100) --Topical corticosteroids 12 1 1 (100) --Systemic corticosteroids and antimalarial b,c, 31 Multiple treatments have been described with pediatric LCLE (Table 1). 3,[6][7][8][9][10][11][12][13][14][15][16][17][19][20][21][22][23][24][25][26][27][28][29][30][31][32]…”

Section: Discussionmentioning

confidence: 99%

“…In a literature review, 35 cases of childhood-onset LCLE were identified, including our 2 cases (1978–2020, conducted through PubMed). 3,6–35 Median age of onset was 9 years old (1–17 years old), with a female predominance of 3F:1M. Different subtypes of CLE with a blaschkoid pattern have been described: discoid CLE (12 cases), lupus panniculitis (11), SCLE (1), bullous systemic lupus erythematosus (SLE) (1) and non-specified (10).…”

Section: Discussionmentioning

confidence: 99%

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Linear cutaneous lupus erythematosus in children—report of two cases and review of the literature: A case report

Lim

Hatami

Kokta

et al. 2020

SAGE Open Medical Case Reports

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Linear cutaneous lupus erythematosus is an unusual presentation of cutaneous lupus following Blaschko’s lines. It is described mostly in children and young adults and is usually not associated with systemic involvement. We report two cases of linear cutaneous lupus erythematosus in children who significantly improved after treatment with hydroxychloroquine in combination with topical corticosteroids and tacrolimus. These rare cases underline the importance of including linear cutaneous lupus erythematosus in the differential diagnosis of blaschkoid inflammatory lesions.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Linear cutaneous lupus erythematosus in children—report of two cases and review of the literature: A case report

Lim

Hatami

Kokta

et al. 2020

SAGE Open Medical Case Reports

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“…8 The differential diagnoses with clinical and dermoscopic examination of the linear non-scarring alopecia, including alopecia areata, trichotillomania, and traction alopecia, could importantly yield explicit data for better diagnosis. Hair loss could be presented in alopecia areata, with a band-like distribution along the hairline, 24 mostly shown as dermoscopic yellow dots, black dots, and exclamation mark hair. 25 Although the bizarre-shaped patches of hair loss was usually found in trichotillomania, with the multiple dermoscopic broken hair shaft abnormalities such as flame-shaped and tulip hair sign without significant inflammation or changes in the perifollicular area.…”

Section: Discussionmentioning

confidence: 99%

Distinctive lupus panniculitis of scalp with linear alopecia along Blaschko's lines: a review of the literature

2018

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Lupus panniculitis of the scalp (LPS) is a rare and distinctive clinical feature of lupus erythematosus panniculitis (LEP) with linear alopecia along Blaschko's lines. In this study, we investigated clinical features and treatments of LPS by literature review of articles in the English language from PubMed and SCOPUS databases up to April 2018. The following key words, "lupus panniculitis, "lupus erythematosus panniculitis", "lupus profundus", "head", and "scalp", were used. Twenty cases of LPS were identified (mean age = 26.4 [10-53] years, female: male ratio = 1:1, mean disease duration = 86.89 [8-336] weeks). The most commonly affected areas of scalp included parietal (70%), frontal (45%), temporal (40%), occipital (30%), and vertex (10%), along 70% of Blaschko's lines with morphologic lesions linear, annular, arch-shaped, and ulcer. Besides, ANA (60%) was in particular noted. Hydroxychloroquine, oral prednisolone, intralesional corticosteroid, and methotrexate were the most common treatments, with complete response after an average period of 8.08 (2-12) weeks. Systemic lupus erythematosus (SLE) was developed in four cases (20%) during follow-up, with high recurrence of 35%. We reported distinctive and rare cases of LPS.The continuing follow-up was highly recommended to avoid probable recurrence and SLE development.

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“…Classic lupus panniculitis/lupus profundus are rarer forms of scarring alopecia specific to lupus [48]. Cases of lupus panniculitis have shown positive responses and complete resolution in some patients with HCQ treatment [48][49][50][51][52][53][54][55][56][57]. A retrospective cohort study found 66.7% of discoid lupus erythematosus patients responding to HCQ [20].…”

Section: Lupus Alopeciamentioning

confidence: 99%

Use of Hydroxychloroquine in Hair Disorders

Ravipati,

Randolph,

Al-Salhi

et al. 2023

Skin Appendage Disord

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Hydroxychloroquine (HCQ) is an antimalarial that is utilized to treat a range of dermatologic and autoimmune disorders. With its ability to alter immunologic mechanisms, it has been used to slow or halt the progression of hair loss in conditions secondary to autoimmune dysfunction. Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and alopecia areata (AA) are hair disorders with underlying autoimmune components and no standardized treatment guidelines. We summarized the available literature on the use of HCQ to treat LPP, FFA, and AA. For all three conditions, HCQ showed variable efficacy from halted hair loss to no improvement. While patients did show success with HCQ treatment, there were no clear treatment patterns. Regimens ranged from HCQ monotherapy to combination treatments with other agents like steroids. Overall, HCQ should certainly be considered by clinicians as a treatment option for patient suffering from these hair disorders. While there is no standardized treatment, incorporation of HCQ should take into consideration individual patient characteristics, clinical judgment, and risks of side effects.

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Two Annular Alopecic Lesions on the Scalp in a Young Asian Man: A Quiz

Abstract: This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta

Cited by 8 publications

References 7 publications

Linear cutaneous lupus erythematosus in children—report of two cases and review of the literature: A case report

Linear cutaneous lupus erythematosus in children—report of two cases and review of the literature: A case report

Distinctive lupus panniculitis of scalp with linear alopecia along Blaschko's lines: a review of the literature

Use of Hydroxychloroquine in Hair Disorders

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