Two anhydrous forms and one monohydrate of a cocrystal of axitinib and glutaric acid: characterization, property evaluation and phase transition study

Ren, Bo-Ying; Dai, Xiaoling; Chen, Jiamei; Lu, Tong‐Bu

doi:10.1039/d1ce01740c

CrystEngComm

2022

DOI: 10.1039/d1ce01740c

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Two anhydrous forms and one monohydrate of a cocrystal of axitinib and glutaric acid: characterization, property evaluation and phase transition study

Bo-Ying Ren

Xiaoling Dai

Jiamei Chen

et al.

Abstract: The polymorphs and hydrates of multi-component crystals have not been studied as extensively as that of single-component crystals. In this work, one anhydrate and one monohydrate of a cocrystal involving...

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Cited by 4 publications

References 49 publications

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Nanocrystal technologies in biomedical science: From the bench to the clinic

Pardhi,

Vasave,

Srivastava

et al. 2024

Drug Discovery Today

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Nanocrystal technologies in biomedical science: From the bench to the clinic

Pardhi,

Vasave,

Srivastava

et al. 2024

Drug Discovery Today

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Advances in Cocrystals of Anticancer Agents: Formulation Strategies and Therapeutic Implications

SINGH,

JAISWAL,

BISHT

2024

Int J Pharm Pharm Sci

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Cancer remains one of the most pressing health concerns worldwide, driving continuous efforts in pharmaceutical research to develop more effective treatments. In the ever-evolving landscape of cancer therapy, cocrystals stand as promising contenders, offering enhanced solubility, stability, and bioavailability to traditional anticancer agents. Co-crystallization, a strategy emerging at the nexus of pharmaceutical and crystal engineering. From the fundamental principles of cocrystal engineering to advanced spectroscopic and crystallographic methodologies, each aspect is meticulously dissected to unveil the transformative potential of cocrystals in oncology. The review elucidates the transformative potential of cocrystals in oncology, highlighting their capacity to revolutionize drug delivery and efficacy. Recent advancements in the field are comprehensively examined, showcasing the promising role of anticancer cocrystals in paving the way for novel therapeutic strategies and improved patient outcomes. Cocrystals represent a promising avenue in cancer therapy, offering significant enhancements to traditional anticancer agents. Through a comprehensive exploration of recent advancements, this article navigates the complex terrain of anticancer cocrystals, drug-drug cocrystals, paving the way for novel therapeutic strategies and improved patient outcomes.

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A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

Meng,

Qiu,

et al. 2024

Front. Pharmacol.

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To overcome the poor solubility, permeability, and bioavailability of the plant isoflavone daidzein (DAI), a novel salt of DAI with anhydrous piperazine (PIP) was obtained based on cocrystallization strategy. The new salt DAI-PIP was characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, and optical microscopy. The results showed that the maximum apparent solubility (Smax) of DAI-PIP increased by 7.27-fold and 1000-fold compared to DAI in pH 6.8 buffer and water, respectively. The peak apparent permeability coefficient (Papp) of DAI-PIP in the Caco-2 cell model was 30.57 ± 1.08 × 10−6 cm/s, which was 34.08% higher than that of DAI. Additionally, compared to DAI, the maximum plasma concentration (Cmax) value of DAI-PIP in beagle dogs was approximately 4.3 times higher, and the area under the concentration-time curve (AUC0-24) was approximately 2.4 times higher. This study provides a new strategy to enhance the dissolution performance and bioavailability of flavonoid drugs, laying a foundation for expanding their clinical applications.

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Two anhydrous forms and one monohydrate of a cocrystal of axitinib and glutaric acid: characterization, property evaluation and phase transition study

Abstract: The polymorphs and hydrates of multi-component crystals have not been studied as extensively as that of single-component crystals. In this work, one anhydrate and one monohydrate of a cocrystal involving...

Cited by 4 publications

References 49 publications

Nanocrystal technologies in biomedical science: From the bench to the clinic

Nanocrystal technologies in biomedical science: From the bench to the clinic

Advances in Cocrystals of Anticancer Agents: Formulation Strategies and Therapeutic Implications

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

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