Abstract. Let N be a closed, oriented 3-manifold. A folklore conjecture states that S 1 × N admits a symplectic structure only if N admits a fibration over the circle. The purpose of this paper is to provide evidence to this conjecture studying suitable twisted Alexander polynomials of N , and showing that their behavior is the same as of those of fibered 3-manifolds. In particular, we will obtain new obstructions to the existence of symplectic structures and to the existence of symplectic forms representing certain cohomology classes of S 1 × N . As an application of these results we will show that S 1 × N (P ) does not admit a symplectic structure, where N (P ) is the 0-surgery along the pretzel knot P = (5, −3, 5), answering a question of Peter Kronheimer.