Twins

Siddiqui, Farah; McEwan, Alec

doi:10.1016/j.ogrm.2007.07.011

Cited by 15 publications

(14 citation statements)

References 7 publications

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“…The increased placental mass predisposes to overproduction of angiostatic factors and thus to placental hypoxia [16]. Obesity, diabetes, pre-existing vascular diseases, and oocyte donation add to the several risk factors for developing pre-eclampsia, which generally has a worse prognosis among twin parturients [1, 2, 11]. In our study, the proportion of pre-eclamptic twin mothers rose from 4.3 to 18.1% during 1996–2006.…”

Section: Discussionmentioning

confidence: 63%

Maternal complications in twin pregnancies in Finland during 1987–2014: a retrospective study

Rissanen

Jernman

Gissler

et al. 2019

BMC Pregnancy Childbirth

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Background To investigate the trends and changes in the incidence and overall outcome of twin pregnancies in Finland, a retrospective study was conducted with emphasis on maternal complications, covering a 28-year study period. Methods All 23,498 twin pregnancies with 46,363 live born and 633 stillborn children in Finland during 1987–2014 were included in the study. Data were collected from the national Medical Birth Register and the Care Register on Hospital Care (Finnish Institute for Health and Welfare, Finland) regarding the parturients’ characteristics and incidences of several pregnancy and childbirth complications. The incidences of twin pregnancies and maternal complications during pregnancy and childbirth are the main outcome measures of the study. The results are expressed in percentages, means, medians, ranges and standard deviations (SD), when appropriate. Results Twins comprised 1.4% of all births in Finland in 1987–2014. Parturients’ mean age has remained stable, but the share of over 35 year-old parturients is increasing. The incidences of pre-eclampsia, intrahepatic cholestasis of pregnancy, gestational diabetes and postpartum haemorrhage have risen during the study period. Almost half (44.9%) of twins were born preterm, almost half via Caesarean section (47.1%), and 27.7% of twin labours were induced. Conclusions Several pregnancy complications increased during the study period. Advanced maternal age among twin parturients has risen, enhancing the risks for developing complications in a pregnancy already of a high-risk category, and predisposing to preterm delivery. National and international guidelines are necessary to improve the overall outcome of twin pregnancies.

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Section: Discussionmentioning

confidence: 63%

Maternal complications in twin pregnancies in Finland during 1987–2014: a retrospective study

Rissanen

Jernman

Gissler

et al. 2019

BMC Pregnancy Childbirth

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“…In the past, the perinatal mortality rate had been reported as 28% in monochorionic and 16% in dichorionic twins. Although outcomes have subsequently improved significantly, perinatal mortality risk is still 1.5% and 3% respectively, compared with 0.5% for singletons (Siddiqui & McEwan, 2007). In twin pregnancies, as compared to singleton pregnancies, preterm birth, fetal death of one of the twins, intrapartum complications, congenital anomalies and twin-to-twin transfusion syndrome have exhibited increases as secondary conditions.…”

Section: Discussionmentioning

confidence: 99%

Perinatal and Neonatal Outcomes of Twin Pregnancies in Turkey

et al. 2011

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This study was conducted for the purpose of assessing, in the light of results of other research carried out in the present researchers' clinic and in Turkey, the status of twin pregnancies in Turkey, the incidence of twin births, perinatal and mortality rates associated with twin pregnancies, and the problems experienced in Turkey in cases of multiple and twin pregnancies.Materials and Methodology:The outcomes of twin births that occurred at the researchers' clinic during the period 2001–2009 were studied retrospectively. Seventeen studies conducted in Turkey on multiple and twin pregnancies during the years 1991–2010 were included in the study.Findings:It was observed that the mean multiple pregnancy rate in Turkey is 1.9% and the mean twin birth rate is 1.7%. It was also observed that a large majority (80–97.3%) of multiple pregnancies in Turkey are twin pregnancies. It was noted from Turkish literature that the mean gestational age of twins at birth varies between 33–36.2 weeks and that mean birthweights are 2065–2327 grams for the first-born twin and 1887–2262 grams for the second-born. These findings were observed to be lower than what is indicated in the literature. Perinatal and neonatal mortality, at 58–156/1000 and 40–98/1000 respectively, were seen to be higher than in the literature.Conclusion:It can be seen that preterm birth rates for twin pregnancies in Turkey are higher than what is indicated in the literature and that prenatal and neonatal mortality rates are also similarly higher.

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“…Maternal constraint, resulting from decreased uterine capacity to deliver sufficient nutrients, oxygen and space to support multiple fetuses, is postulated to be a major factor limiting the survival and growth of the fetus in humans (Blickstein 2005 ) and other mammals (Freetly and Leymaster 2004 ; Gootwine et al 2007 ). Furthermore, the increased frequency of human-twin pregnancies has also increased in the last 20 years leading to more premature and low-birth weight infants (Fliegner 1989 ; Siddiqui and McEwan 2007 ). Intervention strategies however, are not currently available to counter the effects of growth restriction in utero due to multiple-pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep

et al. 2013

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The objective of this study was to evaluate the effects of parenteral administration of L-arginine (Arg) to well-fed twin-bearing ewes from day (d) 100 of pregnancy to birth on fetal growth, body composition and neonatal behavior. Ewes received an i.v. bolus of either 345 μmol Arg-HCl/kg bodyweight or saline solution (control) 3 times a day. At d 140 of pregnancy, Arg-supplemented and control ewes were euthanized and fetal weight and fetal organ weight recorded, and maternal and fetal plasma concentrations of amino acids, hormones and metabolites analyzed. A subset of ewes was allowed to lamb and birth weight, body dimensions and behavior of the lambs in the first 2 hours(h) following birth recorded and blood samples collected. At d 140 of pregnancy, fetal weight internal organ weights were unaffected by treatment with the exception of brown fat stores which were increased by 16% in fetuses from Arg-supplemented ewes relative to controls (P < 0.05). At birth, there was an interaction (P = 0.06) between treatment and sex for birth weight of the lamb. The ewe lambs from Arg-supplemented ewes were 12% (P < 0.05) heavier at birth compared with controls whereas birth weight of male lambs did not differ. These results indicate that maternal Arg supplementation enhanced brown fat stores in the fetus and countered some effect of fetal growth restriction due to litter size in female lambs. Increasing birth weight of female lambs and enhancing brown fat stores of all lambs may have important implications for lamb survival and postnatal growth.

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Twins

Cited by 15 publications

References 7 publications

Maternal complications in twin pregnancies in Finland during 1987–2014: a retrospective study

Maternal complications in twin pregnancies in Finland during 1987–2014: a retrospective study

Perinatal and Neonatal Outcomes of Twin Pregnancies in Turkey

Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep

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