Twinning and oesophageal atresia.

David, T J; O'Callaghan, Sarah E.

doi:10.1136/adc.49.8.660

Cited by 16 publications

(13 citation statements)

References 7 publications

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“…This is at least double the expected birth rate of twins, and indicates a likely association between twinning and OA. Other reports of increased frequency of twins with OA support this association [8,13,27]. There have been 173 reported cases of OA in twins [1,4,8,13,15,26,27,31,34], of which 80% have occurred in same-sex pairs [13,27].…”

Section: Discussionmentioning

confidence: 84%

“…[1,8,13]. Aected infants in conjoined twins [22], with a parasitic twin [24], and in triplet pregnancies [13,27] have also been reported.…”

Section: Introductionmentioning

confidence: 99%

“…The more frequent occurrence of OA in multiple pregnancies is unrelated to the infant's identical or non-identical status. Usually OA aects only one twin, and reports of twins concordant for the oesophageal defect are uncommon [1,4,8,15,26,27,34]. Only 1% of siblings or ospring of OA individuals are aected [33].…”

Section: Introductionmentioning

confidence: 99%

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Oesophageal atresia in twins

Orford

Glasson

Beasley

et al. 2000

Pediatric Surgery International

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The twin incidence is higher in infants with oesophageal atresia (OA) than in the general population. The purpose of this study was to review the twin OA information from five institutions and evaluate possible links between the development of OA and the twinning process. Data were compared, combined, and analysed. There was a total of 1,215 infants with OA, of whom 50 were from a twin pregnancy and 1 from a triplet pregnancy. Two sets of twins were concordant for OA. Mean birth weights and gestational ages were lower in the twin infants (P < 0.0005) and survival was lower in twins (65%, P < 0.005) than singletons. The anatomical variant of pure OA without fistula was seen in proportionally fewer twins (4%) than in singletons (7%). Multiple anomalies were present in 40% of twins compared with 33% of singletons, although this did not reach statistical significance. OA in our multicentre population was more common in twins. Several possible mechanisms are put forward to explain the apparent link between twinning and OA. Further analysis of this aspect of OA may aid in understanding the aetiology of this congenital anomaly.

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Section: Discussionmentioning

confidence: 84%

“…[1,8,13]. Aected infants in conjoined twins [22], with a parasitic twin [24], and in triplet pregnancies [13,27] have also been reported.…”

Section: Introductionmentioning

confidence: 99%

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Oesophageal atresia in twins

Orford

Glasson

Beasley

et al. 2000

Pediatric Surgery International

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“…Further, in patients with EA, the incidence of twinning is higher than statistically expected; usually, EA affects only one of twins [1,6,7]. To the extent of our knowledge, there have been only 20 pairs of twins concordant for the EA anomaly [2][3][4][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In EABT, there was no difference with regard to the sexuality.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that esophageal atresia (EA) occurs at an increased rate in twins and usually affects only one of twins [1,2], whereas the occurrence of EA in both members of twins (EABT) is extremely rare [3]. This paper aims to review and summarize the cases of EABT in the literatures, including our cases.…”

Section: Introductionmentioning

confidence: 99%

Esophageal atresia with tracheoesophageal fistula in both members of monozygotic twins

et al. 2008

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A 29-year-old healthy woman bore monozygotic male twins at 37 weeks of gestation by cesarean section. They weighed 2,350 and 2,140 g, respectively. Twin B was found to have a ventricular septal defect. They were diagnosed with esophageal atresia (EA) with tracheoesophageal fistula and underwent primary end-to-end esophageal anastomosis at the age of 1 day. Their postoperative courses were uneventful. Although the incidence of EA is higher in twins than in singletons, usually, EA affects only one of twins. There have been only 20 pairs of twins concordant for the EA anomaly. There is no distinct difference between sporadic EA and EA in both twins (EABT) with regard to sexuality, classification, and incidence of associated anomalies. The zygosity of EABT consisted of 15 monozygosities (83.3%) and 3 dizygosities (16.7%). An overwhelmingly higher incidence of monozygosity than that of dizygosity in EABT suggests that genetic factors must play a considerable role in the embryology in EABT cases.

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