Abstract:A fundamental limit to high‐density sensing is that adding sensors increases the number of wires, pads, and interconnections. This problem is even worse for low‐values resistive or impedance sensors which, for high accuracy, require 4‐wire measurements. Here, twin‐wire sensor networks are described which enable 4‐wire measurements with significantly fewer wires, pads, and interconnections. The effects of the resistor noise can be minimized by minimum‐resistance sensing paths. A single chopper switch and strai… Show more
“…The significant series parasitic impedances due to the insulating nature of the stratum corneum would result in large errors for 2-wire characterizations of the tissues beyond the stratum corneum (Note S2, Supporting Information). In principle, this issue can be solved by 4-wire (or tetrapolar) bioimpedance measurements [36][37][38] which, only ideally, allow to measure an impedance of interest independently on the parasitic series impedances (Notes S3 and S4, Supporting Information). However, even with ideal 4-wire measurements, a key problem in multilayer structures is to understand which parameters significantly or negligibly contribute to the measured bioimpedance.…”
Section: Analysis Of Multilayer Structures With Normalized Derivativesmentioning
The bioimpedances of tissues beyond the stratum corneum, which is the outermost layer of skin, contain crucial clinical information. Nevertheless, bioimpedance measurements of both the viable skin and the adipose tissue are not widely used, mainly because of the complex multilayered skin structure and the electrically insulating nature of the stratum corneum. Here, a theoretical framework is established for analyzing the impedances of multilayered tissues and, in particular, of skin. Then, strategies are determined for the system‐level design of electrodes and electronics, which minimize 4‐wire (or tetrapolar) measurement errors even in the presence of a top insulating tissue, thus enabling non‐invasive characterizations of tissues beyond the stratum corneum. As an example, non‐invasive measurements of bioimpedances of living tissues are demonstrated in the presence of parasitic impedances which are much (e.g., up to 350 times) higher than the bioimpedances of the living tissues beyond the stratum corneum, independently on extreme variations of the barrier (tape stripping) or of the skin–electrode contact impedances (sweat). The results can advance the development of bioimpedance systems for the characterization of viable skin and adipose tissues in several applications, including transdermal drug delivery and the assessment of skin cancer, obesity, dehydration, type 2 diabetes mellitus, cardiovascular risk, and multipotent adult stem cells.
“…The significant series parasitic impedances due to the insulating nature of the stratum corneum would result in large errors for 2-wire characterizations of the tissues beyond the stratum corneum (Note S2, Supporting Information). In principle, this issue can be solved by 4-wire (or tetrapolar) bioimpedance measurements [36][37][38] which, only ideally, allow to measure an impedance of interest independently on the parasitic series impedances (Notes S3 and S4, Supporting Information). However, even with ideal 4-wire measurements, a key problem in multilayer structures is to understand which parameters significantly or negligibly contribute to the measured bioimpedance.…”
Section: Analysis Of Multilayer Structures With Normalized Derivativesmentioning
The bioimpedances of tissues beyond the stratum corneum, which is the outermost layer of skin, contain crucial clinical information. Nevertheless, bioimpedance measurements of both the viable skin and the adipose tissue are not widely used, mainly because of the complex multilayered skin structure and the electrically insulating nature of the stratum corneum. Here, a theoretical framework is established for analyzing the impedances of multilayered tissues and, in particular, of skin. Then, strategies are determined for the system‐level design of electrodes and electronics, which minimize 4‐wire (or tetrapolar) measurement errors even in the presence of a top insulating tissue, thus enabling non‐invasive characterizations of tissues beyond the stratum corneum. As an example, non‐invasive measurements of bioimpedances of living tissues are demonstrated in the presence of parasitic impedances which are much (e.g., up to 350 times) higher than the bioimpedances of the living tissues beyond the stratum corneum, independently on extreme variations of the barrier (tape stripping) or of the skin–electrode contact impedances (sweat). The results can advance the development of bioimpedance systems for the characterization of viable skin and adipose tissues in several applications, including transdermal drug delivery and the assessment of skin cancer, obesity, dehydration, type 2 diabetes mellitus, cardiovascular risk, and multipotent adult stem cells.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.