Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Calais-Ferreira, Lucas; Oliveira, Vinícius Cunha; Craig, Jeffrey M.; Flander, Louisa; Hopper, John L.; Teixeira-Salmela, Luci Fuscaldi; Ferreira, Paulo H.

doi:10.1016/j.bjpt.2017.12.004

Cited by 10 publications

(6 citation statements)

References 48 publications

(48 reference statements)

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“…A cohort of twins is a great opportunity for epidemiological research as twins can be treated as a regular cohort of individuals; especially when population-based and representative of the general population. 27 The MTR sample has shown to adequately represent the reference population in its geographical area. 28 Consequently, since the objective of this study was not the determination of the relative effects of genetic and environmental factors on the relationship between LBP and physical activity, data on twin zygosity and subsequent analyses are not provided.…”

Section: Design Study Sample and Data Collectionmentioning

confidence: 99%

Is occupational or leisure physical activity associated with low back pain? Insights from a cross-sectional study of 1059 participants

Amorim

Simić

Pappas

et al. 2019

Brazilian Journal of Physical Therapy

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Background: Low back pain is a highly prevalent and disabling musculoskeletal disorder. Physical activity is widely used as a prevention strategy for numerous musculoskeletal disorders; however, there is still conflicting evidence as to whether physical activity is a protective or risk factor for low back pain or whether activity levels differ between people with and without low back pain. Objective: To investigate the association between low back pain and different types (occupational and leisure) and intensities (moderate and vigorous) of physical activity. Methods: This is cross-sectional observational study. We included in this study a total of 1059 individuals recruited from a Spanish twin registry with data available on low back pain. Outcome: Self-reported leisure and occupational physical activity were the explanatory variables. The low back pain outcome used in this study was recurrent low back pain. Results: Our results indicate that leisure physical activity is associated with a lower prevalence of recurrent low back pain. In contrast, occupational physical activity, such as carrying, lifting heavy weight while inclined, awkward postures (e.g. bending, twisting, squatting, and kneeling) are associated with a higher prevalence of recurrent low back pain. There was no statistically significant association between other occupational physical activities, such as sitting or standing, and low back pain. Conclusion: Leisure and occupational physical activity are likely to have an opposed impact on low back pain. While leisure physical activity appears to be protective, occupational physical activity appears to be harmful to low back pain. Future longitudinal studies should assist

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Section: Design Study Sample and Data Collectionmentioning

confidence: 99%

Is occupational or leisure physical activity associated with low back pain? Insights from a cross-sectional study of 1059 participants

Amorim

Simić

Pappas

et al. 2019

Brazilian Journal of Physical Therapy

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“…Musculoskeletal disorders are one of the leading causes of disability. [1] They have been identified as the most important contributor to the "years lived with disability" (YLD) indicator globally, [1,2] accounting for 6.8% of total disability-adjusted life years, increasing by 45% during the period 1990-2011. [3] The substantial increase in the prevalence of musculoskeletal diseases represents a huge economic burden in the national health care systems of developed countries.…”

Section: Burden Of Musculoskeletal Disordersmentioning

confidence: 99%

Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions

Gonzalez-Fernandez

Kelly

O’Brien

2018

Advanced Therapeutics

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“…Opposite‐sex twin studies are, therefore, an essential part of an already comprehensive repertoire of twin study designs that can help answer relevant questions in musculoskeletal health (Calais‐Ferreira et al, 2018). We have established a multinational consortium of twin registries with data from opposite‐sex DZ twin pairs to (1) investigate the association between female sex and risk of lifetime prevalence of LBP while controlling for genetic and nongenetic familial factors, and (2) assess if this association differs by age.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in lifetime prevalence of low back pain: A multinational study of opposite‐sex twin pairs

Calais-Ferreira

Pozzobon

Pinheiro

et al. 2023

European Journal of Pain

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BackgroundLow back pain (LBP) is more likely to occur in people with a family history of this condition, highlighting the importance of accounting for familial factors when studying the individual risk of LBP. We conducted a study of opposite‐sex twin pairs investigating sex differences in LBP while accounting for (genetic and shared environmental) familial factors.MethodsWe applied a matched co‐twin control design to study 795 adult opposite‐sex pairs from Australia, Spain, and the United States (US). We used mixed‐effects logistic regression to assess the within‐pair association between female sex and lifetime prevalence of LBP in unadjusted and adjusted models for body‐mass‐index, and depression, as well as interactions between female sex and age (<median age vs. ≥median age) in this association.ResultsThe mean age of the sample was 47.4 years (Standard Deviation = 16.5). The adjusted odds ratio (aOR) of the association between sex and LBP in the merged sample was 1.11 (95% Confidence Interval = 0.88–1.40), with 87.4% of the variance in the studied association explained by between‐site heterogeneity (Q test; p = 0.001). Females had 2.37 (95% CI: 1.48–3.78) higher odds of LBP compared to their male co‐twins in the Spanish sample (adjusted), but a sex association was not found in the Australian nor US samples.ConclusionsWe found no evidence of the association between sex and LBP in our merged sample. Between‐population differences (i.e. cultural background or health system characteristics) are likely to be major factors leading to variation in the sex association with LBP when familial factors are accounted for.SignificanceOur study of adult opposite‐sex twin pairs found no evidence of an association between female sex and lifetime prevalence of low back pain after controlling for familial factors in the merged sample from Australia, Spain and USA, contrary to findings from previous studies of unrelated individuals. Our findings indicate potentially relevant between‐country genetic, cultural and environmental differences which may need to be considered for optimal and individualized strategies for the prevention and management of low back pain across the lifespan.

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Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Cited by 10 publications

References 48 publications

Is occupational or leisure physical activity associated with low back pain? Insights from a cross-sectional study of 1059 participants

Is occupational or leisure physical activity associated with low back pain? Insights from a cross-sectional study of 1059 participants

Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions

Sex differences in lifetime prevalence of low back pain: A multinational study of opposite‐sex twin pairs

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