Twin screw wet granulation: Effect of powder feed rate

Dhenge, Ranjit M.; Cartwright, J.; Doughty, David G.; Hounslow, Michael J.; Salman, Agba D.

doi:10.1016/j.apt.2010.09.004

Cited by 89 publications

(66 citation statements)

References 8 publications

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“…higher number of kneading elements) showed a slower drug release profile (69.8 to 86.6% released after 45min). These results were in agreement with the conclusions made by Dhenge et al [18]. In this paper, it was noticed that at increased powder feed rate denser granules were produced which took longer time to release the salt embedded in them.…”

Section: Influence Of Process Variables On Tablet Qualitysupporting

confidence: 83%

“…Further optimization of process variables was needed. In accordance to these results, Dhenge et al [18] reported that changing the powder feed rate leads to changes in the size, shape, structure, porosity, strength and dissolution time of the granules. Tan et al [19] used a full-factorial experimental design to describe the effect of granulation liquid composition, injection rate and screw speed on extruder power consumption, granule and tablet properties.…”

Section: Introductionsupporting

confidence: 54%

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Continuous twin screw granulation: Influence of process variables on granule and tablet quality

Vercruysse

Díaz

Peeters

et al. 2012

European Journal of Pharmaceutics and Biopharmaceutics

192

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The aim of the current study was to screen theophylline (125 mg) tablets manufactured via twin screw granulation in order to improve process understanding and knowledge of process variables which determine granule and tablet quality. A premix of theophylline anhydrate, α-lactose monohydrate and PVP (ratio: 30/67.5/2.5, w/w) was granulated with demineralized water. Experiments were done using the high shear wet granulation module (based on twin screw granulation) of the ConsiGma TM -25 unit (a continuous tablet manufacturing system) for particle size enlargement. After drying, granules were compressed using a MODUL TM P tablet press (compression force: 10 kN, tablet diameter: 12 mm). Using a D-optimal experimental design, the effect of several process variables (throughput (10 -25 kg/h), screw speed (600 -950 rpm), screw configuration (number (2, 4, 6 and 12) and angle (30, 60 and 90 degrees) of kneading elements), barrel temperature (25 -40°C) and method of binder addition (dry vs wet)) on the granulation process (torque and temperature increase of barrel wall), granule (particle size distribution, friability and flowability) and tablet (tensile strength, porosity, friability, disintegration time and dissolution) quality was evaluated. The results showed that the quality of granules and tablets can be optimized by adjusting specific process variables (number of kneading elements, barrel temperature and binder addition method) during a granulation process using a continuous twin screw granulator.

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Section: Influence Of Process Variables On Tablet Qualitysupporting

confidence: 83%

Section: Introductionsupporting

confidence: 54%

Continuous twin screw granulation: Influence of process variables on granule and tablet quality

Vercruysse

Díaz

Peeters

et al. 2012

European Journal of Pharmaceutics and Biopharmaceutics

192

View full text Add to dashboard Cite

show abstract

“…As flow rate has reported significant influence on granule size and porosity in the literature [3,6,9,17,18], its negligible effect on the results of this study may be attributed to the formulation but may also be related to the fact that the selected factor levels were insufficiently different to note change. It is not believed that flow rate can, in general, be disregarded as a factor affecting granulation.…”

Section: Discussioncontrasting

confidence: 57%

Function of upstream and downstream conveying elements in wet granulation processes within a twin screw extruder

2015

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“…Only a limited number of studies on twin screw granulation addressed formulation development while most studies focused on the influence of process parameters on granule quality [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]. Moreover, most studies used formulations with lactose or microcrystalline cellulose as fillers.…”

Section: Introductionmentioning

confidence: 99%

Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation

Vanhoorne

Bekaert

Peeters

et al. 2016

International Journal of Pharmaceutics

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To refer to or to cite this work, please use the citation to the published version:Vanhoorne V., Bekaert B., Peeters E., De Beer T., Remon J.P., Vervaet C. (2016) Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation. International Journal of Pharmaceutics 506 13-24 DOI: 10.1016/j.ijpharm.2016.04.025 AbstractIn most formulations processed via continuous twin screw granulation microcrystalline cellulose (MCC) and/or lactose are used as excipients, but mannitol is also a preferred excipient for wet granulation and tableting due to its non-hygroscopicity and inertness.Therefore, the aim of the current study was to investigate the influence of process parameters on critical quality attributes of granules (moisture content, solid state, morphology, size distribution, specific surface area, friability, flowability and hygroscopicity) and tablets (tensile strength and friability) after twin screw granulation of δ-mannitol. The δ-polymorph was selected since a moisture-induced transformation to β-mannitol was observed during batch wet granulation, which exhibited a unique morphology with a large surface area and improved tabletability. A full factorial experimental design was performed, varying screw speed (400 -900 rpm), granulation temperature (25 -40 °C), number of kneading elements (6 or 12) and liquid-to-solid (L/S) ratio, on the granulation unit of a ConsiGma TM -25 line (a continuous powder-to-tablet manufacturing system). After tray drying the granules were milled and tableted. The results showed that the polymorphic transition from δ-to β-mannitol also occurred during twin screw granulation, although the residence time and L/S ratios were much lower in continuous twin screw granulation compared to batch processing. However, the polymorphic transition was not complete in all experiments and depended on the L/S ratio, screw speed and number of kneading elements. Nevertheless all granules exhibited the unique morphology linked to the polymorphic transition and had a superior tabletability compared to granules produced with β-mannitol as starting material. This was attributed to enhanced plastic deformation of the granules manufactured using δ-mannitol as starting material. In addition, it was concluded that mannitol was granulated via a different mechanism than other, lesssoluble, excipients (e.g. lactose, microcrystalline cellulose) due to its high solubility and dissolution rate as the influence of process parameters on the mannitol granule characteristics was different.

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Twin screw wet granulation: Effect of powder feed rate

Cited by 89 publications

References 8 publications

Continuous twin screw granulation: Influence of process variables on granule and tablet quality

Continuous twin screw granulation: Influence of process variables on granule and tablet quality

Function of upstream and downstream conveying elements in wet granulation processes within a twin screw extruder

Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation

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