Twin-screw granulation: Understanding the mechanical properties from powder to tablets

Khorsheed, Bilal; Gabbott, Ian; Reynolds, Gavin K.; Taylor, Stefan C.; Roberts, R.J.; Salman, Agba D.

doi:10.1016/j.powtec.2018.05.013

Cited by 13 publications

(2 citation statements)

References 35 publications

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“…The findings of this work suggested that the granule and tablet quality can be optimised by adjusting specific process variables. Khorsheed et al (2017) also investigated the effect of TSG processing parameters on the powder and granule and tablet properties using microcrystalline cellulose (MCC) or mannitol C160 [ 64 ]. Their study showed increasing MCC granule size and strength can reduce tabletability and vice versa.…”

Section: Twin Screw Granulationmentioning

confidence: 99%

Advances in Twin-Screw Granulation Processing

et al. 2021

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Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology has evolved rapidly due to the flexibility of the equipment design, the selection of the process variables and the wide range of processed materials. Most importantly, TSG offers the benefits of both batch and continuous manufacturing for pharmaceutical products, accompanied by excellent process control, high product quality which can be achieved through the implementation of Quality by Design (QbD) approaches and the integration of Process Analytical Tools (PAT). Here, we present basic concepts of the various twin-screw granulation techniques and present in detail their advantages and disadvantages. In addition, we discuss the detail of the instrumentation used for TSG and how the critical processing paraments (CPP) affect the critical quality attributes (CQA) of the produced granules. Finally, we present recent advances in TSG continuous manufacturing including the paradigms of modelling of continuous granulation process, QbD approaches coupled with PAT monitoring for granule optimization and process understanding.

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Section: Twin Screw Granulationmentioning

confidence: 99%

Advances in Twin-Screw Granulation Processing

et al. 2021

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“…A good understanding of the mechanisms that govern the wet granulation process is very important to be able to incorporate control strategies, as well as the Quality by Design (QbD) paradigm, into a new drug development process. In that sense, various types of experimental research have been conducted to understand the process itself, the influence of process parameters (PPs), formulation, and equipment design on the properties of the final granules [1,3,4,5,6,7,8,9,10,11]. Numerous mechanistic modeling approaches have aimed to reproduce the observed experimental behavior of the TSWG process, including the physical phenomena that have been identified as part of the process such as wetting, nucleation, consolidation, growth, breakage, and attrition [12,13].…”

Section: Introductionmentioning

confidence: 99%