Twin pregnancies conceived by assisted reproductive techniques: Maternal and neonatal outcomes

Bernasko, James; Lynch, Lauren; Lapinski, Robert; Berkowitz, Richard L.

doi:10.1016/s0029-7844(96)00527-3

Cited by 103 publications

(60 citation statements)

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“…Studies of spontaneously conceived versus ART twins have most often shown the latter to have significantly higher rates of preterm birth, low birthweight, prematurity-associated morbidity and mortality (6,7,(9)(10)(11)(15)(16)(17)(18)(19)(20)(21), and birthweight discordancy (8,21,22). Even studies that have adjusted for monochorionic placentation and monozygosity, which are associated with growth restriction, have concluded that ART pregnancies have poorer outcomes (7,23).…”

Section: Discussionmentioning

confidence: 99%

The effect of early fetal losses on twin assisted-conception pregnancy outcomes

Luke

Brown

Grainger

et al. 2009

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

The effect of early fetal losses on twin assisted-conception pregnancy outcomes

Luke

Brown

Grainger

et al. 2009

Fertility and Sterility

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“…(22,23) Others have found no significant differences between assisted and spontaneous pregnancies after stratification, (24) or restriction to singletons (25)(26)(27)(28)(29) or multiple gestations. (29)(30)(31)(32)(33)(34) It thus remains unclear whether the association between infertility treatments and gestational hypertension is due to biologic factors intrinsic to couples with infertility problems, to patient characteristics such as older age and primiparity, to the higher rate of multiple gestations, or to the specific infertility treatment. We therefore investigated the association between fertility treatments and gestational hypertension, with specific emphasis on the effect of different technologies and specific fertility drugs, as well as the role of multiple gestations and specific patient characteristics.…”

Section: Introductionmentioning

confidence: 99%

Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestations

Hernández–Dı́az

Werler

Mitchell

2007

Fertility and Sterility

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Objective-To investigate the association between infertility treatments and gestational hypertension and preeclampsia. Design-Retrospective observational cohort. Setting-General population, United States and Canada.Patients-5151 women with non-malformed infants participating in the Slone Epidemiology Center Birth Defects Study between 1998 and 2006.Interventions-Women were interviewed within six months after delivery about sociodemographic and medical factors, the onset of gestational hypertension and preeclampsia, and about infertility treatments.Main Outcome Measures-We estimated relative risks and 95% confidence intervals using unconditional logistic regression.Results-The incidence of gestational hypertension was 8.9% (423/4762) among women without infertility treatments, and 15.8% (55/349) among women undergoing infertility treatments. Compared to spontaneous pregnancies, the crude relative risk for gestational hypertension in pregnancies resulting from infertility treatments was 1.9 (95% confidence interval 1.4-2.6). Multivariate adjustment for parity and pre-pregnancy BMI resulted in a relative risk of 1.6 (1.1-2.1). Further adjustment for multiple pregnancies, or restriction of the analyses to singleton pregnancies, moved the relative risk to 1.3. Each specific infertility procedure or drug was associated with a similarly elevated risk, which disappeared after adjustment for multiple gestations. Results were similar for preeclampsia.Corresponding Author: Allen A. Mitchell, M.D., Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA, Tel: (617) 734 6006, Fax: (617) 738 5119, e-mail: E-mail: amitchell@slone.bu.edu. Conflict of interest: None CAPSULE:The higher incidence of gestational hypertension and preeclampsia in pregnancies resulting from infertility treatments is largely explained by the higher frequency of multiple gestations.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion-Pregnancies resulting from infertility treatments have a higher incidence of gestational hypertension and preeclampsia than spontaneous conceptions. This increased risk is largely explained by the higher frequency of multiple gestations. NIH Public Access

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“…Historically, the transfer of multiple embryos led to a greater chance of pregnancy but also an increased risk of multiple birth and its associated costs, including higher risks of neonatal and obstetric complications. Elective single embryo transfer (eSET) eliminates all risk of multiple pregnancy except spontaneous identical twinning but may compromise a patient's chance of having a live birth altogether (1)(2)(3)(4).…”

mentioning

confidence: 99%

Predicting personalized multiple birth risks after in vitro fertilization–double embryo transfer

Lannon

Choi

Hacker

et al. 2012

Fertility and Sterility

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Twin pregnancies conceived by assisted reproductive techniques: Maternal and neonatal outcomes

Abstract: Although twin pregnancies following IVF or GIFT are more likely to result in discordant birth weight infants, the perinatal outcome is comparable to that of spontaneously conceived twin pregnancies.

Cited by 103 publications

References 10 publications

The effect of early fetal losses on twin assisted-conception pregnancy outcomes

The effect of early fetal losses on twin assisted-conception pregnancy outcomes

Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestations

Predicting personalized multiple birth risks after in vitro fertilization–double embryo transfer

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