Twice the recommended daily allowance of iron is associated with an increase in plasma α-1 antichymotrypsin concentrations in Guatemalan school-aged children

Rosales, Francisco J.; Kang, Yu Sun; Pfeiffer, Beate; Rau, Annegret; Romero‐Abal, María‐Eugenia; Erhardt, Juergen; Solomons, Noel W.; Biesalski, Hans Konrad

doi:10.1016/j.nutres.2004.06.008

Cited by 13 publications

(7 citation statements)

References 41 publications

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“…Other micronutrients There were no differences in the prevalence of zinc deficiency 51 or in the serum levels of zinc, 51 lead, 47-50 retinol 26 or copper.…”

Section: Hematologic and Iron Indicesmentioning

confidence: 90%

“…Six studies (2651 children) excluded participants who failed to take a predefined percentage of supplements (ranging from 66% to 90% of total tablets). 22,23,44,[47][48][49][50][51]55 Five studies (1894 children) compared adherence between children taking iron and control; they reported similar proportions of children taking at least a specified percentage of tablets. 19,21,25,27,33 CMAJ, November 19, 2013, 185 (17) E799…”

Section: Adherencementioning

confidence: 99%

See 1 more Smart Citation

Effects of daily iron supplementation in primary-school–aged children: systematic review and meta-analysis of randomized controlled trials

Löw

Farrell

Biggs

et al. 2013

CMAJ

127

113

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“…Other micronutrients There were no differences in the prevalence of zinc deficiency 51 or in the serum levels of zinc, 51 lead, 47-50 retinol 26 or copper.…”

Section: Hematologic and Iron Indicesmentioning

confidence: 90%

Section: Adherencementioning

confidence: 99%

Effects of daily iron supplementation in primary-school–aged children: systematic review and meta-analysis of randomized controlled trials

Löw

Farrell

Biggs

et al. 2013

CMAJ

127

113

View full text Add to dashboard Cite

“…Thus, 60 mg iron/day increased thiobarbituric acid-reactive substances in pregnant women [83] , breath alkanes in human adults increased after a single dose of 10 mg iron [84] and supplementation of 20 mg iron/day increased the acute-phase protein, ␣ 1 -antichymotrypsin, in Guatemalan children [85] . Additional field research points in the same direction.…”

Section: Iron Effects In the Tissuesmentioning

confidence: 96%

Efficacy and Safety of Iron Administration in Juvenile Populations

Schümann

Solomons²

2010

Ann Nestlé [Engl]

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Infantile iron deficiency anemia (IDA) reduces maximal lifetime cognitive capacity and can threaten the life of an adolescent mother in childbirth. Administration of iron is a component of strategies for preventing or reversing iron deficiency (ID) and iron can be given parenterally or as oral supplements or fortified food. Safety issues can arise at the point of administration, i.e. in the gut lumen, and as a consequence of excessive iron stores arising from the interventions. Recent improvements in the pharmacology of parenteral iron compounds open the way to greater consideration of the intravenous route in pediatric therapy, and even public health. Oral iron supplementation, usually with folic acid, is the main treatment of IDA in the clinical setting. It is often combined with multiple micronutrients and is also used for resolution of severe anemia at the community level and for prophylaxis in the nonanemic population. Fortification of staple food (such as flour), or age-specific foods (infant formula, complementary foods) and beverages are the usual methods for ID prophylaxis. Special iron-rich preparations (powders, crushable tablets, edible spreads) are available for home fortification. Biofortification, i.e. enriching the iron content of crops during cultivation, is a novel approach, yet to be fully implemented or evaluated for children. Side effects and toxicity after oral iron intake are seen in the gut lumen. After oral and parenteral iron intake, the rise in circulating iron can increase the risk of complications from coexisting infections, notably with malaria, and when individual iron status is adequate. Growth impairment occurs with exposure of iron-sufficient children to iron interventions, so that targeting of iron to ID individuals seems advisable. Numerous adverse consequences from accumulation of excessive total body iron stores show up as a consequence of iron-mediated oxidative stress. Incomplete maturation of iron homoeostasis may permit higher iron absorption before 6 months of age.

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“…Por lo tanto, 60 mg de hierro/día incrementaban las sustancias reactivas de ácido tiobarbitúrico en mujeres gestantes [83] , los alcanos respiratorios en adultos humanos aumentaron después de una dosis única de 10 mg de hierro [84] , y el aporte complementario de 20 mg de hierro/día incrementó la proteína de fase aguda, antiquimotripsina ␣ 1 , en niños guatemaltecos [85] . La investigación de campo adicional apunta en la misma dirección.…”

Section: Efectos Del Hierro En Los Tejidosunclassified

Eficacia y seguridad de la administración de hierro en poblaciones juveniles

Schümann¹,

Solomons²

2010

Ann Nestlé [Esp]

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La anemia por carencia de hierro (ACH) del lactante reduce su capacidad cognitiva máxima de por vida y puede poner en riesgo la vida de una madre adolescente en el parto. La administración de hierro es un componente de las estrategias encaminadas a prevenir o invertir la carencia de hierro (CH), y el hierro puede administrarse por vía parenteral o mediante aportes complementarios o alimentos enriquecidos por vía oral. Pueden suscitarse problemas de seguridad en el lugar de administración, es decir, en la luz intestinal, que aparecerían a partir de las intervenciones como consecuencia de depósitos de hierro excesivos. Las mejoras recientes en la farmacología de los compuestos de hierro parenterales despejan el camino en terapia pediátrica e incluso en salud pública. El aporte complementario de hierro por vía oral, habitualmente junto al ácido fólico, es el tratamiento principal de la ACH en el entorno clínico. A menudo se combina con múltiples micronutrientes y se utiliza también para la resolución de la anemia grave en el ámbito extrahospitalario y para la profilaxis en la población no anémica. El enriquecimiento de alimentos básicos (como harina) o alimentos (leche para lactantes, alimentos complementarios) y bebidas específicos de la edad son los métodos habituales para la profilaxis de la CH. Se dispone de preparados especiales ricos en hierro (polvos, comprimidos disgregables, productos comestibles para untar) destinados al enriquecimiento casero. El bioenriquecimiento, es decir, el enriquecimiento del contenido en hierro de cosechas durante el cultivo es un abordaje novedoso que todavía tiene que ser puesto en práctica o evaluado íntegramente en relación con niños. En la luz intestinal se observan efectos secundarios y signos tóxicos tras la ingestión oral de hierro. Después de la administración oral y parenteral, el aumento del hierro circulatorio puede incrementar el riesgo de complicaciones a partir de infecciones coexistentes, especialmente en el caso del paludismo, y cuando el estado individual de hierro es suficiente. Se produce un deterioro del crecimiento en caso de exposición de niños con suficiencia de hierro a intervenciones con este nutriente, de manera que parece aconsejable orientar el hierro a individuos afectados de CH. Aparecen numerosas consecuencias adversas por la acumulación de depósitos de hierro excesivos en todo el cuerpo como resultado de la agresión oxidativa mediada por hierro. La maduración incompleta de la homeostasis del hierro puede permitir una mayor absorción de hierro antes de los 6 meses de edad.

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Twice the recommended daily allowance of iron is associated with an increase in plasma α-1 antichymotrypsin concentrations in Guatemalan school-aged children

Cited by 13 publications

References 41 publications

Effects of daily iron supplementation in primary-school–aged children: systematic review and meta-analysis of randomized controlled trials

Effects of daily iron supplementation in primary-school–aged children: systematic review and meta-analysis of randomized controlled trials

Efficacy and Safety of Iron Administration in Juvenile Populations

Eficacia y seguridad de la administración de hierro en poblaciones juveniles

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