Twenty years of unrestricted hematopoietic stem cell collection and storage: impact of Joint Accreditation Committee International Society for Cellular Therapy Europe standards implementation on stem cell storage policy and resource utilization

Piccirillo, Nicola; Ausoni, Giuseppe; Chiusolo, Patrizia; Sorà, Federica; Putzulu, Rossana; Bianchi, Maria; Maresca, Maddalena; Fiore, Alberto; Oppedisano, Paolo; Sica, Simona; Zini, Gina; Leone, Giuseppe

doi:10.1016/j.jcyt.2012.12.003

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…In vitro analysis reported that the EnSCs positively express stage-specific embryonic antigen-4) SSEA-4 (and octamer-binding transcription factor 4 (OCT4) markers and decrease OCT4 expression with increasing passages that confirm its stemness ( Piccinato et al, 2015 ). The EnSCs also expressed high levels of CD73, CD90, CD105, and CD166, but they lacked CD14, CD34, and CD45 expression, which are very similar to the minimum characteristics of MSCs defined by the committee of the International Society for Cellular Therapy ( Piccirillo et al, 2013 ). The EnSCs also have a high proliferation, multidirectional, and differentiation capacity that is indicative of the potential for tissue regeneration ( Ai and Ebrahimi, 2010 ).…”

Section: Endometrial-derived Stem Cells: All-in-one For Limb Regenera...supporting

confidence: 55%

Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells

Khodayari

Ebrahimi‐Barough

et al. 2022

Front. Cell Dev. Biol.

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As an evidence-based performance, the rising incidence of various ischemic disorders has been observed across many nations. As a result, there is a growing need for the development of more effective regenerative approaches that could serve as main therapeutic strategies for the treatment of these diseases. From a cellular perspective, promoted complex inflammatory mechanisms, after inhibition of organ blood flow, can lead to cell death in all tissue types. In this case, using the stem cell technology provides a safe and regenerative approach for ischemic tissue revascularization and functional cell formation. Limb ischemia (LI) is one of the most frequent ischemic disease types and has been shown to have a promising regenerative response through stem cell therapy based on several clinical trials. Bone marrow-derived mononuclear cells (BM-MNCs), peripheral blood CD34-positive mononuclear cells (CD34+ PB-MNCs), mesenchymal stem cells (MSCs), and endothelial stem/progenitor cells (ESPCs) are the main, well-examined stem cell types in these studies. Additionally, our investigations reveal that endometrial tissue can be considered a suitable candidate for isolating new safe, effective, and feasible multipotent stem cells for limb regeneration. In addition to other teams’ results, our in-depth studies on endometrial-derived stem cells (EnSCs) have shown that these cells have translational potential for limb ischemia treatment. The EnSCs are able to generate diverse types of cells which are essential for limb reconstruction, including endothelial cells, smooth muscle cells, muscle cells, and even peripheral nervous system populations. Hence, the main object of this review is to present stem cell technology and evaluate its method of regeneration in ischemic limb tissue.

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Section: Endometrial-derived Stem Cells: All-in-one For Limb Regenera...supporting

confidence: 55%

Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells

Khodayari

Ebrahimi‐Barough

et al. 2022

Front. Cell Dev. Biol.

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“…The success of JACIE is an excellent example for clinical quality and accreditation systems in other specialities. A number of potential factors stand out: the early acceptance by some BMT opinion leaders of the need for quality, international professional society support; 25 the early realisation at local level of the organisational impact 26 and incorporation into national regulatory requirements. Once acceptance of, and trust in, a system is established, the more controversial aspects, such as standardised performance benchmarking of survival outcomes and minimal centre activity, can be presented as further means of quality improvement.…”

Section: Discussionmentioning

confidence: 99%

JACIE accreditation for blood and marrow transplantation: past, present and future directions of an international model for healthcare quality improvement

Snowden

McGrath²,

Duarte

et al. 2017

Bone Marrow Transplant

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Blood and marrow transplantation (BMT) is a complex and evolving medical speciality that makes substantial demands on healthcare resources. To meet a professional responsibility to both patients and public health services, the European Society for Blood and Marrow Transplantation (EBMT) initiated and developed the Joint Accreditation Committee of the International Society for Cellular Therapy and EBMT—better known by the acronym, JACIE. Since its inception, JACIE has performed over 530 voluntary accreditation inspections (62% first time; 38% reaccreditation) in 25 countries, representing 40% of transplant centres in Europe. As well as widespread professional acceptance, JACIE has become incorporated into the regulatory framework for delivery of BMT and other haematopoietic cellular therapies in several countries. In recent years, JACIE has been validated using the EBMT registry as an effective means of quality improvement with a substantial positive impact on survival outcomes. Future directions include development of Europe-wide risk-adjusted outcome benchmarking through the EBMT registry and further extension beyond Europe, including goals to faciliate access for BMT programmes in in low- and middle-income economies (LMIEs) via a ‘first-step’ process.

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“…The cells were capable of differentiating into adipocytes, osteocytes, and chondrocytes in vitro, which indicated their multipotency [12, 31]. According to the definition provided by the Committee of the International Society for Cellular Therapy, MSCs are multipotent cells that are adhere to plastic; that express CD73, CD90, and CD105 instead of CD14, CD34, CD45, and HLA-DR; and that must be able to differentiate into osteoblasts, adipocytes, and chondroblasts in vitro [32]. Accordingly, the above results indicate that the cells we isolated and cultured were EMSCs.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis

Cheng

Wang

et al. 2017

Stem Cells International

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Human endometrial tissue has become an attractive source of mesenchymal stem cells (MSCs) for cell-based therapies because these MSCs can be easily harvested and have tumour tropism as well as reduced immunogenic and inflammatory properties. Our study aimed to obtain and characterise human endometrial mesenchymal stem cells (EMSCs) and assess their endometriosis tropism. EMSCs were successfully isolated from the endometrium of women undergoing laparoscopy for idiopathic infertility. The EMSCs presented a fibroblast-like morphology during culture. Flow cytometry analyses showed that the cells were positive for the specific stem cell markers CD73, CD90, CD105, CD166, and HLA-ABC (major histocompatibility complex class I (MHC I)) but negative for CD14, CD34, CD45, and HLA-DR (MHC II). Reverse transcription polymerase chain reaction results showed that the EMSCs expressed the stem cell marker OCT4. The EMSCs could differentiate into osteocytes, adipocytes, and chondrocytes under certain conditions. The EMSCs had a high tropism to endometriosis without tumourigenicity. This study enhances the possibility of using EMSCs as drug carriers in human cell-based therapies. Meanwhile, future research could also focus on developing targeted therapies for endometriosis.

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Twenty years of unrestricted hematopoietic stem cell collection and storage: impact of Joint Accreditation Committee International Society for Cellular Therapy Europe standards implementation on stem cell storage policy and resource utilization

Cited by 5 publications

References 3 publications

Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells

Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells

JACIE accreditation for blood and marrow transplantation: past, present and future directions of an international model for healthcare quality improvement

Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis

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