Twenty Years of Follow-Up among Survivors of Childhood and Young Adult Acute Myeloid Leukemia (AML): A Report from the Childhood Cancer Survivor Study (CCSS).

Mulrooney, Daniel A.; Dover, Douglas C.; Yasui, Yutaka; Ness, Kirsten K.; Mertens, Ann C.; Neglia, Joseph P.; Sklar, Charles A.; Robison, Leslie L.; Davies, Stella M.

doi:10.1182/blood.v108.11.560.560

Cited by 33 publications

(73 citation statements)

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“…12,27,36,[39][40][41]46 Working life Table 2b summarises the findings of 29 studies of the employment status and occupations of childhood cancer survivors. 55 Ghaderi, 2013 24 Bonneau, 2011 60 Freycon, 2014 96 Mulrooney, 2008 North America AML exposed to chemotherapy and/or radiotherapy…”

Section: Educational Achievementsmentioning

confidence: 99%

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Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes

Frederiksen

Mader

Feychting

et al. 2018

Intl Journal of Cancer

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Substantial improvements in childhood cancer survival have resulted in a steadily increasing population of childhood cancer survivors. Whereas somatic late effects have been assessed in many studies, less is known about the impact of childhood cancer on socioeconomic outcomes in survivors. The aim of this article was to evaluate and summarise the evidence on the socioeconomic conditions of childhood cancer survivors and to identify survivors at particular risk of adverse socioeconomic outcomes. An extensive literature search of three electronic databases was conducted. Of 419 articles identified, 52 met the inclusion criteria. All the selected articles were appraised for quality, and findings were summarised in a narrative synthesis. Childhood cancer survivors were at higher risk of adverse socioeconomic outcomes with regard to educational achievement, income and social security benefits than the general population or a sibling comparison group. The risks for unemployment and a lower occupational position were significantly increased only for survivors of a central nervous system tumour. Notably, survivors of central nervous system tumours, survivors treated with cranial radiotherapy and those diagnosed at younger age independent of cancer type were determinants of particular adverse socioeconomic outcomes. Given the increasing population of childhood cancer survivors, targeted follow-up interventions and support strategies addressing not only the somatic and psychiatric late effects but also the socioeconomic difficulties that some childhood cancer survivors face is of high importance to reduce social inequity, and ensure a high quality of life after childhood cancer.

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Section: Educational Achievementsmentioning

confidence: 99%

“…Survivors aged 25-34 years who received CRT at 24 Gy achieved lower educational level than those receiving CRT at 18 Gy (p = 0.01). 96…”

Section: (Continues)mentioning

confidence: 99%

Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes

Frederiksen

Mader

Feychting

et al. 2018

Intl Journal of Cancer

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“…Nevertheless, marriage rates comparable to those of controls also have been reported. [40][41][42][43][44][45] Such inconsistent findings may be attributed to heterogeneous samples and treatment with various levels of neurotoxic agents.…”

Section: Introductionmentioning

confidence: 99%

Psychosexual development and satisfaction in long‐term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator

Lehmann

Tuinman

Keim

et al. 2017

Cancer

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BACKGROUND Risk factors for impairment in psychosexual development and satisfaction among adult survivors of childhood cancer are poorly understood. The authors compared psychosexual outcomes between survivors and healthy controls, and tested whether at‐risk survivors can be identified by 1) treatment neurotoxicity or 2) diagnosis. METHODS A total of 144 young adult survivors of childhood cancer and 144 matched controls completed questionnaires regarding psychosexual development, sexual satisfaction, and satisfaction with relationship status. Survivors were aged 20 to 40 years and were 5 to 34 years after diagnosis. Using medical chart data, survivors were divided into non‐neurotoxic (48 survivors), low‐dose (36 survivors), and high‐dose (58 survivors) neurotoxic treatment groups. RESULTS Apart from having fewer lifetime sex partners, survivors did not appear to differ from controls. However, survivors of brain tumors and any survivor who received high‐dose neurotoxic treatment reported the lowest rates of achieving milestones of psychosexual development, whereas sexual and relationship status satisfaction were found to be related to relationship status. Neurotoxic treatment intensity further distinguished between survivors of brain tumors with and without psychosexual impairment. CONCLUSIONS The intensity of neurotoxic treatment may be a valuable indicator of risk for psychosexual impairment relative to diagnosis alone. Health care providers should assess romantic/sexual problems among survivors at risk and make referrals if needed. Cancer 2017;123:1869–1876. © 2017 American Cancer Society.

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“…26 In both studies, the cumulative incidence of second malignant neoplasm was low, as was the incidence of cardiac disease. 25,26 However, since 2002, AML trials in the United States have used higher cumulative doses of anthracyclines (approximately 450 mg/m 2 ) than earlier trials, suggesting that the prevalence of late cardiotoxicity may increase to the levels observed in the United Kingdom. 27 Long-term follow-up according to international guidelines is essential.…”

Section: Discussionmentioning

confidence: 89%

“…26 Despite these issues, rates of marriage, pregnancy, high school graduation, employment, and health insurance coverage were similar among survivors and their siblings. 26 In both studies, the cumulative incidence of second malignant neoplasm was low, as was the incidence of cardiac disease. 25,26 However, since 2002, AML trials in the United States have used higher cumulative doses of anthracyclines (approximately 450 mg/m 2 ) than earlier trials, suggesting that the prevalence of late cardiotoxicity may increase to the levels observed in the United Kingdom.…”

Section: Discussionmentioning

confidence: 99%

Definition of cure in childhood acute myeloid leukemia

Rubnitz

Inaba

Leung

et al. 2014

Cancer

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Background A better understanding of when cure can be declared in childhood acute myeloid leukemia (AML) would reduce anxiety and improve quality of life of AML survivors. We determined the likelihood of patients with AML to maintain long-term remission after completion of therapy. Patients and Methods The cumulative risk of relapse, time to relapse, event-free survival and overall survival were analyzed for 604 patients with AML enrolled in seven successive clinical trials, divided into 3 treatment eras (1976–1991, 1991–1997, 2002–2008). Results The median time to relapse did not change over time (0.93 years vs. 0.76 vs. 0.8 years for each consecutive era, P = .22) but the risk of relapse decreased significantly (5-year cumulative incidence of relapse 52.6% ± 3.1% vs. 31.5% ± 3.9% vs. 22.0% ± 3.0%, P < .001). Among patients who were in remission 4 years from diagnosis, the probabilities of relapse were 1.7%, 2.9%, and 0.9%, respectively. In the most recent era, all 44 relapses except one occurred within four years of diagnosis. Conclusion Children with AML who are treated with contemporary therapy and remain in remission four years from diagnosis are likely cured. Although late relapses and late deaths from other causes are rare, long-term follow up of survivors is necessary for timely management of late adverse effects.

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Twenty Years of Follow-Up among Survivors of Childhood and Young Adult Acute Myeloid Leukemia (AML): A Report from the Childhood Cancer Survivor Study (CCSS).

Cited by 33 publications

References 0 publications

Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes

Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes

Psychosexual development and satisfaction in long‐term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator

Definition of cure in childhood acute myeloid leukemia

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