Twenty Years of Clinical Experience with a New Modality of Vascular-Targeted Photodynamic Therapy for Port Wine Stains

Qiu, Haixia; Gu, Ying; Wang, Ying; Huang, Naiyan

doi:10.1111/j.1524-4725.2011.02129.x

Cited by 57 publications

(35 citation statements)

References 31 publications

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“…Several alternative modalities, including intense pulse light and photodynamic therapy, have proven beneficial for treatment-resistant CMs, although a significant response or complete resolution is only seen in approximately 50% of patients for both modalities. [30][31][32][33] VENOUS MALFORMATIONS Venous malformations (VMs) are the most common vascular malformation, accounting for 44-64% of all vascular malformations. 34 They are classified according to the Hamburg classification 35 as truncular or extratruncular, with 40% of lesions localized to the extremities, 20% on the trunk and 40% on the head and neck.…”

Section: Capillary Malformationsmentioning

confidence: 99%

Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches

Mulligan

Prajapati²,

Martin

et al. 2014

BJR

161

132

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The term vascular anomaly represents a broad spectrum of vascular pathology, including proliferating vascular tumours and vascular malformations. While the treatment of most vascular anomalies is multifactorial, interventional radiology procedures, including embolic therapy, sclerotherapy and laser coagulation among others, are playing an increasingly important role in vascular anomaly management. This review discusses the diagnosis and treatment of common vascular malformations, with emphasis on the technique, efficacy and complications of different interventional radiology procedures.

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Section: Capillary Malformationsmentioning

confidence: 99%

Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches

Mulligan

Prajapati²,

Martin

et al. 2014

BJR

161

132

View full text Add to dashboard Cite

show abstract

“…Gu et al [29,30] reported that among 1942 PWS lesions in 1385 patients treated by either PSD-007 or HMME from April 1991 to May 2003 showed that, after one PDT treatment session, total clearance was achieved in 128 lesions (6.6%), achieved excellent results, 746 (38.3%) good results, 923 (47.4%) fair results, 145 (7.4%) results, and seven (0.3%) with no visible change. Their data showed that PDT was an effective treatment in all patients with PWS, especially for dark-skinned patients or patients with papules or nodules.…”

Section: Photomedicine -Advances In Clinical Practicementioning

confidence: 99%

Photodynamic Therapy

Liu¹,

Cai²

2017

Photomedicine - Advances in Clinical Practice

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Photodynamic therapy (PDT) employs light activation of tissue-localized photosensitizer in an oxygen-dependent process which initiates oxidative stress, inflammation, and cell death. Photodynamic therapy (PDT) involves the activation of a previously administered photosensitizing agent by visible light to induce tumor necrosis. Photosensitizers are topically applied in the treatment of skin tumors to avoid systemic side effects. The main dermatology indications for topical PDT are superficial nonmelanoma skin cancer and dysplasia, notably superficial basal carcinoma (BCC), Bowen's disease (BD), and actinic keratosis (AK). In this chapter, we evaluated the feasibility and efficacy of aminolevulinic acid (ALA) as a photosensitizer (ALA-PDT) in combination with CO 2 laser in the treatment of dermatological disease from basics to clinic research.

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“…2,3 It is known that light, photosensitizer and oxygen are the three primary factors for PDT but photosensitizer is the key important one. An ideal photosensitizer should possess high PDT activity but low dark toxicity as well as fast clearance from tissues, in addition, it should be readily delivered but not seriously sacri¯ce the PDT activity in vivo.…”

Section: Introductionmentioning

confidence: 99%

Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

Deng

Xie

Zhao

2015

J. Innov. Opt. Health Sci.

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Photodynamic therapy (PDT) has been a routine treatment of tumors and some microvascular diseases, but clinically available photosensitizers are still scarce. Among all kinds of photosensitizers, hypocrellins possess the most characteristics of ideal photosensitizers, such as, high photo-activity but low dark toxicity, fast clearance from tissues. This review is focused on two main topics, drug-delivery problem of hypocrellins and how the environment-sensitive°uorescence of hypocrellins was used for recognition of various biomolecules. Drug-delivery of hypocrellins was mainly achieved in two strategies -preparing the drug-delivery vehicles and¯nding quantitatively amphiphilic derivatives. Hypocrellin°uorescence originated from the intramolecular proton transfer is very distinct from other kinds of photosensitizers. Recently, it was proved that quantitative hypocrellin°uorescence could not only recognize various biomolecules, including proteins, polysaccharides and lipids, but also distinguish the speci¯c binding from nonspeci¯c binding with some kind of biomolecules. Meantime, hypocrellin°uorescence was pH-sensitive. It is known that tumor cells or tissues have the features of a large amount of lipid, neonatal collagen, over-expression of polysaccharides, and lower pH values compared to normal tissues. According to the relative but not absolute speci¯city, further studies on quantitative recognition of various biomolecules at a cellular level, may¯nd a new clue to treat tumors by joint usage of photodynamic diagnosis (PDD) and PDT.

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Twenty Years of Clinical Experience with a New Modality of Vascular-Targeted Photodynamic Therapy for Port Wine Stains

Abstract: This new PDT is an effective, safe, and noninvasive modality with no recurrence for PWS, although the protocol for PDT requires further optimization.

Cited by 57 publications

References 31 publications

Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches

Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches

Photodynamic Therapy

Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

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