Twenty-year trends in all-cause mortality of patients with systemic lupus erythematosus in Mexico: Results from a nationwide health registry

Mendoza‐Pinto, Claudia; Etchegaray‐Morales, Ivet; Munguía‐Realpozo, Pamela; Méndez‐Martínez, Socorro; Osorio-Peña, Ángel David; Montiel-Jarquín, Álvaro José

doi:10.1177/09612033221078228

Cited by 9 publications

(11 citation statements)

References 52 publications

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“…As previously mentioned, we recently reported mortality trends in SLE during 1998-2017. 20 In that study, the AAPC during the whole study period increased (AAPC: 2.7%, 95% CI 1.1, 4.4). However, analysis of some segments with joinpoint analysis showed that from 1998 to 2018, the APC significantly increased, particularly in women (4.9%), but after that non-significant changes in the trend were detected, reflecting a possible stabilization of death rates in recent last years.…”

Section: Discussionmentioning

confidence: 76%

Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Mendoza‐Pinto

Etchegaray‐Morales

Munguía‐Realpozo

et al. 2022

Lupus

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Background Hospitalizations due to systemic lupus erythematosus (SLE) incur substantial resource use. Hospitalization trends provide a key benchmark of the disease burden. However, there is little long-term data in Mexico. Therefore, we evaluated Mexican hospitalization trends for SLE during 2000–2019. Methods Hospitalization trends of SLE were studied using data from 2000 to 2019 releases of the National Dynamic Cubes of the General Direction of Health Information, which provides data on hospitalization discharges in Mexico. Patients aged ≥15 years hospitalized during the study period with a principal discharge diagnosis of SLE (ICD-10 code M32) were included. Results From 2000 to 2019, there were 17,081 hospitalizations for SLE, of which 87.6% were in females and 87% in subjects aged 15–44 years. From 2000 to 2019, the age-standardized hospitalization rate for patients with SLE increased from 0.38 per 100,000 persons to 0.65 per 100,000 persons with an average annual percentage change (APC) of 2.9% (95% CI 6.2–63.2). Although there was a significant uptrend from 2000 through 2011, there was a significant decline from 2011 to 2019 (APC: −4.8%, 95% CI −7.0% to −2.5%). Similar trends were identified in subjects aged 15–44 years and in both sexes. The length of stay and inpatient mortality decreased between 2000–2009 and 2010–2019. Conclusions Although there was a substantial increase in SLE hospitalizations in 2000–2019, in 2011–2019, a decreased trend was reported in younger patients and in females and males. The length of stay was also reduced.

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Section: Discussionmentioning

confidence: 76%

Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Mendoza‐Pinto

Etchegaray‐Morales

Munguía‐Realpozo

et al. 2022

Lupus

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“…The overall mortality risk is two- to three-times higher for persons with SLE in comparison to the general population, but higher still in certain global regions and racial/ethnic groups [ 5 ]. Recent global updates include a study from Mexico that used a nationwide health registry to report all-cause mortality in SLE [ 22 ]. The age-specific mortality rate (ASMR) increased from 0.49 (95% CI 0.26, 0.57) per 100 000 persons in 1998 to 0.89 (95% CI 0.72, 1.1) per 100 000 persons in 2017, representing a relative increase of 81.6% [ 22 ].…”

Section: Recent Updates In the Global Burden Of Slementioning

confidence: 99%

“…Recent global updates include a study from Mexico that used a nationwide health registry to report all-cause mortality in SLE [ 22 ]. The age-specific mortality rate (ASMR) increased from 0.49 (95% CI 0.26, 0.57) per 100 000 persons in 1998 to 0.89 (95% CI 0.72, 1.1) per 100 000 persons in 2017, representing a relative increase of 81.6% [ 22 ]. Over the same period, ASMR in the general population decreased by 8.6% [ 22 ].…”

Section: Recent Updates In the Global Burden Of Slementioning

confidence: 99%

“…The age-specific mortality rate (ASMR) increased from 0.49 (95% CI 0.26, 0.57) per 100 000 persons in 1998 to 0.89 (95% CI 0.72, 1.1) per 100 000 persons in 2017, representing a relative increase of 81.6% [ 22 ]. Over the same period, ASMR in the general population decreased by 8.6% [ 22 ]. The authors suggest that socioeconomic determinants and barriers to healthcare access, including difficulty obtaining newer therapeutics, may be contributing to worsening outcomes.…”

Section: Recent Updates In the Global Burden Of Slementioning

confidence: 99%

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The global epidemiology of SLE: narrowing the knowledge gaps

et al. 2023

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SLE is a global health concern that unevenly affects certain ethnic/racial groups. Individuals of Asian, Black, Hispanic and Indigenous ethnicity/race are amongst those who experience increased prevalence, incidence, morbidity and mortality. Population-based surveillance studies from many regions are few and often still in nascent stages. Many of these areas are challenged by restricted access to diagnostics and therapeutics. Without accurately capturing the worldwide burden and distribution of SLE, appropriately dedicating resources to improve global SLE outcomes may be challenging. This review discusses recent SLE epidemiological studies, highlighting the challenges and emerging opportunities in low- and middle-income countries. We suggest means of closing these gaps to better address the global health need in SLE.

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“…Previous studies have shown the influence of ethnicity and socioeconomic status on SLE’s risk and prognosis. Higher disease activity, organ damage accumulation, as well as a higher rate of mortality has been observed in SLE patients from Latin American, North American admixed population, African descendants, and Native American patients (Barber et al, 2021; Drenkard & Lim, 2019; Lewis & Jawad, 2017; Mendoza-Pinto et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Lupus RGMX: Social and Clinical Characteristics and their Contribution to Quality of Life in a Mexican Cohort with SLE

Hernández-Ledesma

Martínez

Fajardo-Brigido

et al. 2023

Preprint

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BACKGROUND. Although higher prevalence, disease activity, damage accumulation and mortality of systemic lupus erythematosus (SLE) are observed among Latin American, North American admixed population, African descendants and Native Americans, the information about SLE in Latin American countries, such as Mexico, is scarce. OBJECTIVES. To present Lupus RGMX, a multidisciplinary effort to generate a national digital patient registry to enrich the understanding of Mexican people with SLE. METHODS. Mexican patients with SLE registered between May 2021 and January 2023 in Lupus RGMX were included. Sociodemographic, socioeconomic and clinical characteristics, along with quality of life perception (QoL) were assessed using self-reported data. We compared the QoL obtained from patients with SLE with two groups of non-SLE Mexican subjects. Descriptive statistics, comparisons analyses and a multivariate nonparametric regression model were performed. RESULTS. A total of 1172 of lupus patients were included; of which 93.9% were women. The mean age±SD was 36.6±10.7 years, with 37.1% of the individuals between 41 and 50 years. The 24.9% reported a calculated monthly income of 430 USD (8,612 MXN). Lower QoL scores were observed in the SLE group, especially in subjects with lower socioeconomic level. Health perception, QoL perception and socioeconomic status were the variables with greater importance to predict total WHOQoL scores. CONCLUSION. The design and implementation of Lupus RGMX imply a pioneering approach to unraveling SLE in Mexicans. Further studies from Lupus RGMX will be focused on enriching the representation of the Mexican population and include other aspects that may allow us to improve our understanding of the disease in our population.

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Twenty-year trends in all-cause mortality of patients with systemic lupus erythematosus in Mexico: Results from a nationwide health registry

Cited by 9 publications

References 52 publications

Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

Trends in all-cause hospitalizations for systemic lupus erythematosus in Mexico, 2000–2019

The global epidemiology of SLE: narrowing the knowledge gaps

Lupus RGMX: Social and Clinical Characteristics and their Contribution to Quality of Life in a Mexican Cohort with SLE

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