Twenty year multi-follow-up of different types of hallucinations in schizophrenia, schizoaffective disorder, bipolar disorder, and depression

Goghari, Vina M.; Harrow, Martin

doi:10.1016/j.schres.2016.06.027

Cited by 30 publications

(23 citation statements)

References 38 publications

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“…1,40,51 There were fewer studies conducted with people in depressive mood states, and there were only three studies that directly contrasted AH frequencies across affective subtypes. 46,55,57 Higher AH rates in mania were confirmed in these studies, but the differences reported were actually quite modest. Further examination of AH phenomena may therefore be required within the depressive phases of BD.…”

Section: Auditory Hallucinationsmentioning

confidence: 54%

“…Psychotic episodes in BD may therefore be neither singular nor entirely discrete experiences. Nevertheless, the typically transient nature of AHs in BD and their unique association with affective episodes was demonstrated by other studies, as was the tendency for AHs to be less frequently reported over time in BD than in, for example, SCZ spectrum conditions . Indeed, a longitudinal study by Goghari et al.…”

Section: Resultsmentioning

confidence: 83%

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Characterizing the experience of auditory verbal hallucinations and accompanying delusions in individuals with a diagnosis of bipolar disorder: A systematic review

2017

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Section: Auditory Hallucinationsmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 83%

Characterizing the experience of auditory verbal hallucinations and accompanying delusions in individuals with a diagnosis of bipolar disorder: A systematic review

2017

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“…They are prevalent in both psychiatric disorders, such as schizophrenia (60-80%) 2 and bipolar disorder (BD 10-23%) 3 , and neurodegenerative diseases, such as Parkinson's disease (PD; 22-38%) 4 , dementia with Lewy Bodies (DLB; 80%) 5 , and Alzheimer's disease (AD; 13-18%) 6 , as well as in other psychiatric and neurological disorders, and among the general population (4.5-12.7%) 7 . Irrespective of diagnosis, the presence of hallucinations marks an increased risk of adverse outcomes, such as reduced likelihood of recovery in schizophrenia 8 , more severe cognitive deficits in PD 9 , increased mortality in AD 10 , increased suicidal behaviour in adults with psychosis 11 , and transition to later mental illness in children and young adults 12,13 . Although hallucinations are often distressing, they may also be benign or contribute to meaningful personal experiences 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Meta-analytic evidence for the plurality of mechanisms in transdiagnostic structural MRI studies of hallucination status

Rollins

Garrison

Simons

et al. 2018

Preprint

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BACKGROUND:Hallucinations are transmodal and transdiagnostic phenomena, occurring across sensory modalities and presenting in psychiatric, neurodegenerative, neurological, and non-clinical populations. Despite their cross-category occurrence, little empirical work has directly compared between-group neural correlates of hallucinations. METHODS:We performed whole-brain voxelwise meta-analyses of hallucination status across diagnoses using AES-SDM, and conducted a comprehensive systematic review in PubMed and Web of Science until May 2018 on other structural correlates of hallucinations, including cortical thickness and gyrification.FINDINGS: 3214 abstracts were identified. Patients with psychiatric disorders and hallucinations (eight studies) exhibited reduced gray matter (GM) in the left insula, right inferior frontal gyrus, left anterior cingulate/paracingulate gyrus, left middle temporal gyrus, and increased in the bilateral fusiform gyrus, while patients with neurodegenerative disorders with hallucinations (eight studies) showed GM decreases in the left lingual gyrus, right supramarginal gyrus/parietal operculum, left parahippocampal gyrus, left fusiform gyrus, right thalamus, and right lateral occipital gyrus. Group differences between meta-analyses were formally confirmed and a jackknife sensitivity analysis established the reproducibility of results across nearly all study combinations. For other measures (28 studies), the most consistent findings associated with hallucination status were reduced cortical thickness in temporal gyri in schizophrenia and altered hippocampal volume in Parkinson's disease and dementia. INTERPRETATION: Distinct patterns of neuroanatomical alteration characterize hallucination status in patientswith psychiatric and neurodegenerative diseases, suggesting a plurality of anatomical signatures. This approach has implications for treatment, theoretical frameworks, and generates refutable predictions for hallucinations in other diseases and their occurrence within the general population. FUNDING: None. Research in context Evidence before this studyThere is increasing recognition that hallucinations occur beyond the archetype of schizophrenia, presenting in other psychiatric disorders, neurological and neurodegenerative conditions, and among the general population. Not only are hallucinations a transdiagnostic phenomenon, but also the experience of hallucinating is phenomenologically diverse, varying in modality, content, frequency, and affect. It has been suggested that no one type of hallucination is pathognomic to any one disorder, but rather that hallucinations may exist on a continuum. However, limited research has been done to directly compare the underlying neuroanatomy of hallucinations between different disorders. With this aim, we conducted a meta-analysis and systematic review of structural MRI studies comparing individuals who experience hallucinations with those who do not, to investigate the brain morphology related to the transdiagnostic presentation of hallucinations. We...

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“…In a longitudinal study following 150 psychosis patients for 20 years, 40%-45% of the schizophrenia patients had frequent or persistent hallucinations during this period, 3 and having AH at index hospitalization was associated with a reduced likelihood of recovery over the next 20 years. 4 Despite extensive efforts to elucidate the neural mechanisms underlying AH in schizophrenia patients, [5][6][7] so far the neurobiological underpinnings remain obscure.…”

Section: Introductionmentioning

confidence: 99%

Auditory Cortex Characteristics in Schizophrenia: Associations With Auditory Hallucinations

Mørch-Johnsen

Nesvåg

Jørgensen

et al. 2016

Schizophrenia Bulletin

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There were no significant differences between AH+ and AH− patients in cortical thickness in the PT or STG, or in auditory cortex surface area in any of the regions investigated. Group differences in cortical thickness in the left HG was not affected by duration of illness or current antipsychotic medication. Conclusions: AH in schizophrenia patients were related to thinner cortex, but not smaller surface area of the left HG, a region which includes the primary auditory cortex. The results support that structural abnormalities of the auditory cortex underlie AH in schizophrenia.

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Twenty year multi-follow-up of different types of hallucinations in schizophrenia, schizoaffective disorder, bipolar disorder, and depression

Cited by 30 publications

References 38 publications

Characterizing the experience of auditory verbal hallucinations and accompanying delusions in individuals with a diagnosis of bipolar disorder: A systematic review

Characterizing the experience of auditory verbal hallucinations and accompanying delusions in individuals with a diagnosis of bipolar disorder: A systematic review

Meta-analytic evidence for the plurality of mechanisms in transdiagnostic structural MRI studies of hallucination status

Auditory Cortex Characteristics in Schizophrenia: Associations With Auditory Hallucinations

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