Twenty-Year Experience With Liver Transplantation for Hepatocellular Carcinoma

Island, Eddie; Pomposelli, James J.; Pomfret, Elizabeth A.; Gordon, Fredric D.; Lewis, W. David; Jenkins, Roger L.

doi:10.1001/archsurg.140.4.353

Cited by 30 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…recurrence [7,11,15]. To improve patients`outcome, it is of great clinical importance to find reliable prognostic markers, which could predict relapse and dissemination of HCC.…”

mentioning

confidence: 99%

KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study

et al. 2007

View full text Add to dashboard Cite

The KiSS-1 gene has been reported to play an important role as a metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in hepatocellular carcinoma (HCC). In this study, we evaluated the prognostic significance of the expression of KiSS-1 and its receptor AXOR12 in 142 HCC tissue specimens by immunohistochemistry. By using a cutoff level of 50%, immunoreactivity of KiSS-1 and AXOR12 was found in 6 (4%) and 11 (8%) HCCs. The expression of KiSS-1 and AXOR12 in HCC correlated with each other (r = 0.42, p < 0.0001) and with the expression in corresponding, surrounding liver tissue (both r = 0.35, p < 0.0001). Positive AXOR12 immunoreactivity in HCC correlated with advanced pT-stage of tumors and low tumor grading (r = 0.18, p = 0.032; r = -0.18, p = 0.029). High KiSS-1 expression in HCC had a statistically significant influence on diminished disease-free and overall survival in uni- (p = 0.006 and p = 0.002) and multivariate analysis (r = 2.874, p = 0.027 and r = 2.913, p = 0.026). In this study, we report for the first time that elevated KiSS-1 expression level in HCC correlates with worsened clinical outcome, as an independent prognostic marker for the aggressiveness of HCC.

show abstract

“…recurrence [7,11,15]. To improve patients`outcome, it is of great clinical importance to find reliable prognostic markers, which could predict relapse and dissemination of HCC.…”

mentioning

confidence: 99%

KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…The part of liver tissue obtained by needle biopsy, in many instances, particularly in cases of CLD fails to provide a correct assessment of changes in the whole liver [15,18]. Some of the recent reports on the epidemiology of different types of end-stage CLD in the general population and their future projections have been based, to a significant extent, on data from LT centers [2][3][4]. A review of the etiologic assessment of CLD (even though not done in as extensive a manner as in our LT cases) in a much larger number of cases seen in our hospital liver clinics over the same period of time showed frequencies of the different categories to be very similar to those in the study reported here.…”

Section: Discussionmentioning

confidence: 99%

“…If not detected and treated early, a number of these progress to an irreversible stage, become refractory to treatment, and invariably lead to fatal complications. Success in liver transplantation (LT) achieved during the last two decades has provided substantial relief to such cases of end-stage CLD [1][2]. Besides, analyses of data from different LT centers in developed countries have yielded a considerable important information such as epidemiology and temporal changes in end-stage CLD [1,[2][3][4], detection of precancerous lesions and small cancers in the liver [6,7] as well as selection, prioritization, and management of cases in an LT program [1,2,6].…”

Section: Introductionmentioning

confidence: 99%

Etiologic types of end-stage chronic liver disease in adults

Nayak¹,

Jain²,

Vasdev³

et al. 2012

European Journal of Gastroenterology & Hepatology

View full text Add to dashboard Cite

The etiology of end-stage CLD in adults of our region has changed over time. HCV, more than HBV, is now the major cause of both CLD and HCC; alcohol-related CLD has increased significantly and several cases of cirrhosis clinically considered as cryptogenic, some of them with HCC, evolve from NAFLD. A proportion of cryptogenic cirrhosis cases that require LT are constituted by the noncirrhotic disease noncirrhotic portal fibrosis.

show abstract

“…Despite the lack of preoperative recognition, the concomitant presence of hemochromatosis and HCC or cholangiocellular carcinoma did not influenced short-term survival (55 vs. 58%). A few other additional studies report on liver transplantation and HCC in the context of HH [21,22] . However, the lack of adequate information available on the outcome of these patients prevented us from including them in our analysis.…”

Section: Review Of the Literature With Reference To Resectability Ratmentioning

confidence: 99%

Surgery for Hepatocellular Carcinoma Arising in Hereditary Hemochromatosis

Sotiropoulos

Molmenti²,

Lang³

et al. 2006

Eur Surg Res

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma (HCC) is a well-known complication of hereditary hemochromatosis. The benefit of surgical therapy in this clinical entity is not well documented. The purpose of this study was to evaluate the outcome of such patients both in our own experience as well as in the published literature. Methods: 320 patients with a diagnosis of HCC were evaluated at our institution to undergo either surgical resection (n = 262) or liver transplantation (n = 58) during the 4- year period from January 2001 to December 2004. We identified 5 patients with HCC arising in the setting of hemochromatosis. A literature search was performed to estimate resectability rates as well as outcomes after liver transplantation for HCC arising in hemochromatosis. Results: HCC was multifocal in 4 instances and solitary in 1 case. The liver was cirrhotic in all but 1 case. Three patients underwent an exploratory laparotomy, 1 an exploratory laparoscopy, and 1 underwent transplantation. HCC was unresectable in all cases. The patient with a solitary tumor and cirrhosis underwent 5 sessions of transarterial chemoembolization and is alive 37 months after surgical exploration. The 3 patients with multifocal tumors who underwent exploratory laparotomies died within 6 months after the intervention. The fifth patient who underwent a deceased donor split liver transplantation for multifocal tumor is alive without recurrence 3 years after transplantation. These results are similar to those in the literature that concur with the low resectability rate and the favorable outcome after liver transplantation. Conclusion: Resectability rates of HCCs arising in hemochromatosis are extremely low, given that tumors are usually multifocal and the livers cirrhotic in the majority of the instances. Early detection of hemochromatosis as well as intensive tumor screening of cirrhotic patients with hemochromatosis could possibly optimize the role of surgery or accelerate the decision to proceed with liver transplantation.

show abstract

Twenty-Year Experience With Liver Transplantation for Hepatocellular Carcinoma

Cited by 30 publications

References 28 publications

KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study

KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study

Etiologic types of end-stage chronic liver disease in adults

Surgery for Hepatocellular Carcinoma Arising in Hereditary Hemochromatosis

Contact Info

Product

Resources

About