Twenty-year analysis of photobiomodulation clinical studies for oral mucositis: a scoping review

Kauark‐Fontes, Elisa; Migliorati, Cesar A.; Epstein, Joel B.; Bensadoun, René-Jean; Gueiros, Luiz Alcino Monteiro; Carroll, James D.; Ramalho, Luciana Maria Pedreira; Santos‐Silva, Alan Roger

doi:10.1016/j.oooo.2022.12.010

Cited by 8 publications

(5 citation statements)

References 91 publications

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“…Since then, PBM has been well described in the literature as an intervention to prevent and decrease the severity of OM in patients undergoing HSCT. 7,[9][10][11] PBM can be administered with either an extraoral probe, an intraoral probe, or both (Figure 1). PBM is applied for 1 minute per site and is painless.…”

Section: Photobiomodulation Therapymentioning

confidence: 99%

“…6 Despite being a strong recommendation with high certainty evidence, PBM remains an underutilized tool in the pediatric HSCT patient population, particularly in North America. 7…”

Section: Introductionmentioning

confidence: 99%

“…These guidelines recommended that intraoral photobiomodulation (PBM) in the red light spectrum (620–750 nm) be used for pediatric patients undergoing autologous or allogeneic HSCT and those receiving radiotherapy for head and neck carcinoma 6 . Despite being a strong recommendation with high certainty evidence, PBM remains an underutilized tool in the pediatric HSCT patient population, particularly in North America 7 …”

Section: Introductionmentioning

confidence: 99%

“…Light therapy or laser therapy, as PBM was historically named, was first shown to have therapeutic properties over 50 years ago and is a combination of red light, which has been shown to have healing properties, and near‐infrared light, which has demonstrated a reduction in pain and inflammation. Since then, PBM has been well described in the literature as an intervention to prevent and decrease the severity of OM in patients undergoing HSCT 7,9–11 . PBM can be administered with either an extraoral probe, an intraoral probe, or both (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Implementation of a light therapy team to administer photobiomodulation therapy: A standardized protocol to prevent and treat oral mucositis in the pediatric hematopoietic stem cell transplant population

Magee,

Robins,

Staton

et al. 2024

Pediatric Blood & Cancer

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BackgroundOral mucositis (OM) is a painful and common complication of hematopoietic stem cell transplant (HSCT). The Children's Oncology Group recently published guidelines recommending photobiomodulation (PBM) for preventing and treating OM in pediatric HSCT patients. However, this is a rarely used intervention in pediatric hospitals.ProcedurePatients undergoing allogeneic HSCT, or autologous HSCT for a neuroblastoma diagnosis, had PBM administered from the first day of conditioning to transplant Day +20. We successfully developed a standardized treatment protocol and workflow to ensure consistent and uniform delivery of PBM. In addition, clinical patient data were compared before and after PBM implementation.ResultsThe administration of PBM at our center was feasible, but required dedicated staff. A registered nurse (RN) was determined to be the best fit to deliver PBM. Sixty‐two patients received PBM from October 2022 to September 2023; patients from 2021 before PBM implementation were used for comparison. Patients receiving PBM were more likely (p = .03) to engage in teeth brushing (56/62 = 90%) compared to baseline (61/81 = 75%). Mean days of OM decreased from 11.3 to 9 days; patients who received PBM were less likely (p < .001) to be discharged on total parental nutrition (TPN) (11/62 = 18%) compared to baseline (50/82 = 61%). OM‐related supportive care costs (TPN and patient‐controlled anesthesia [PCA]) were lower (p = .02) for those who received PBM (median cost = $31,229.87 vs. $37,370.66).ConclusionPBM, as the standard of care in the pediatric HSCT population, is safe, feasible, and well‐tolerated. At our center, a dedicated RN was critical to providing standardized treatment and ensuring sustainability.

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Section: Photobiomodulation Therapymentioning

confidence: 99%

“…6 Despite being a strong recommendation with high certainty evidence, PBM remains an underutilized tool in the pediatric HSCT patient population, particularly in North America. 7…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Implementation of a light therapy team to administer photobiomodulation therapy: A standardized protocol to prevent and treat oral mucositis in the pediatric hematopoietic stem cell transplant population

Magee,

Robins,

Staton

et al. 2024

Pediatric Blood & Cancer

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“…Opinions have been well established, through peer-review publications, to support the wide scope of PBM within all aspects of clinical dentistry [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Effect of Photobiomodulation Therapy Dosage on Orthodontic Movement, Temporomandibular Dysfunction and Third Molar Surgery Outcomes: A Five-Year Systematic Review

Parker,

Cronshaw,

Anagnostaki

et al. 2024

Applied Sciences

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(1) Background: This five-year systematic review seeks to assess the impact of oral and peri-oral photobiomodulation therapies (PBMTs) on the adjunctive management of deeper tissue biofunction, pathologies related to pain and inflammatory disorders and post-surgical events. (2) Methods: The search engines PubMed, Cochrane, Scopus, ScienceDirect, Google Scholar, EMBASE and EBSCO were used with appropriate Boolean operatives. The initial number of 14,932 articles was reduced to 261. Further exclusions performed to identify PBM therapy in third molar surgery, orthodontic and TMJ articles resulted in 19, 15 and 20 of these, respectively. Each paper was scrutinised to identify visible red–NIR laser wavelength PBM applications, concerning dosimetry and outcomes. (3) Results: A dataset analysis was employed using post hoc ANOVA and linear regression strategies, both with a Bonferroni correction (p < 0.05). The outcomes of articles related to oral surgery pain revealed a statistically significant relation between PBMT and a positive adjunct (p = 0.00625), whereas biofunction stimulation across all other groupings failed to establish a positive association for PBMT. (4) Conclusions: The lack of significance is suggested to be attributable to a lack of operational detail relating to laser operating parameters, together with variation in a consistent clinical technique. The adoption of a consistent parameter recording and the possible inclusion of laser data within ethical approval applications may help to address the shortcomings in the objective benefits of laser PBM.

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Oral Management of Cancer Patients After Multimodality Therapy

Prado‐Ribeiro

Santos‐Silva

Fonseca

et al. 2023

Clinical Decision-Making in Oral Medicine

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Twenty-year analysis of photobiomodulation clinical studies for oral mucositis: a scoping review

Cited by 8 publications

References 91 publications

Implementation of a light therapy team to administer photobiomodulation therapy: A standardized protocol to prevent and treat oral mucositis in the pediatric hematopoietic stem cell transplant population

Implementation of a light therapy team to administer photobiomodulation therapy: A standardized protocol to prevent and treat oral mucositis in the pediatric hematopoietic stem cell transplant population

Effect of Photobiomodulation Therapy Dosage on Orthodontic Movement, Temporomandibular Dysfunction and Third Molar Surgery Outcomes: A Five-Year Systematic Review

Oral Management of Cancer Patients After Multimodality Therapy

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