Twenty-three years of Klebsiella phage typing: a review of phage typing of 12 clusters of nosocomial infections, and a comparison of phage typing with K serotyping

Abstract

In an outbreak situation, phage typing was found to be very useful, although it seems less suitable for long-term surveillance purposes.

Humoral Immune Response to Klebsiella Spp. In New Zealand Sea Lions (Phocarctos Hookeri) and the Passive Transfer of Immunity to Pups

“…However, this serologic technique could not discriminate between serum antibodies against the immunologically related K. pneumoniae and K. oxytoca (Rissing et al, 1978;Sechter et al, 2000). This lack of specificity did not negatively impact the present study because the WB technique proved to be a suitable method for screening large numbers of archived serum samples and seemed to be very sensitive.…”

Two T7-like Bacteriophages, K5-2 and K5-4, Each Encodes Two Capsule Depolymerases: Isolation and Functional Characterization

“…Phage depolymerases, which are often a part of the tail spike or tail fiber, can degrade bacterial capsular polysaccharides into their oligosaccharide units during infection. As such, the use of phages for Klebsiella capsular typing has been previously described 32, 33 . Such lytic phages can also be used as therapeutic agents 34–36 .…”

Epidemiological typing of multidrug-resistant Klebsiella pneumoniae, which causes paediatric ventilator-associated pneumonia in Egypt

“…Rapid and discriminative subtyping methods are useful for determining the clonal relatedness of nosocomial K. pneumoniae infections and hence tracing the source of infection [15,16]. The commonly applied typing methods for K. pneumoniae are biotyping [17], phage typing [18], serological typing [19], antimicrobial sensitivity profiles (resistotyping) [20] and molecular typing. Molecular typing methods include multilocus sequence typing (MLST), random amplification of polymorphic DNA (RAPD) and pulsed-field gel electrophoresis (PFGE) [21][22][23][24].…”