Twenty‐three novel HLA‐B alleles identified during intermediate‐resolution testing

Lázaro, A. M.; Cao, Kai; Masaberg, Carly; Steiner, Noriko; Xiao, Yi; Tu, Bin; Turner, Victoria; Nickerson, Peter; Stoll, Scott T.; Schall, Cynthia; Valdez, Riccardo; Ng, Jennifer; Hartzman, Robert J.; Hurley, Carolyn Katovich

doi:10.1111/j.1399-0039.2006.00661.x

Cited by 13 publications

(12 citation statements)

References 5 publications

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“…The same situation is present in the case of B*39:31 which was reported for the first time in 2006 (24), but data about its distribution is scarce. At this moment its presence is reported in DKMS among minorities (Bosnia and Herzegovina, Croatia, Greece, Italy, Romania and Turkey) as well as among Germans (19).…”

supporting

confidence: 55%

Nonfrequent but well‐documented, rare and very rare HLA alleles observed in the Croatian population

et al. 2014

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The aim of the study was to evaluate the presence of nonfrequent, rare and very rare alleles among Croats and to estimate whether they are associated with specific alleles at other human leukocyte antigen (HLA) loci. This retrospective study included the typing results from the last 10 years; total number of individuals included was approximately 45,000. Among 17 alleles so far observed only once in our population, 6 (A*24:41, B*07:02:28, B*35:03:03, B*39:40N, DRB1*13:23 and DRB1*14:111) belong to very rare alleles, 2 (B*44:16 and DRB1*01:31) belong to rare alleles according to the 'Rare Alleles Detector' tool ( www.allelefrequencies.net), while for the B*35:101:01 allele published data exist only in the IMGT/HLA database. The remaining eight HLA alleles observed only once among Croats are considered as frequent according to the 'Rare Alleles Detector'. Those 17 HLA alleles are not declared as common well defined (CWD) alleles in the CWD allele catalogue 2.0.0. Haplotype analysis of nonfrequent alleles detected in our sample supports the idea that different populations, although similar in some aspects regarding HLA allele and haplotype distribution, still have some unique characteristics. This is the case for A*01:02, B*39:10 and DRB1*13:32 which form haplotypes unreported to date among our subjects.

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supporting

confidence: 55%

Nonfrequent but well‐documented, rare and very rare HLA alleles observed in the Croatian population

et al. 2014

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“…Sequencing of several random bacterial colonies determined the sequence of the allele. Both HLA‐B alleles from a cell were also sequenced together using previously described primers by our group (4) to provide an additional confirmation of the two alleles present.…”

Section: Cells and Their Hla Allelesmentioning

confidence: 99%

Expanding diversity at the HLA‐B locus: 28 novel HLA‐B alleles

Lázaro

Xiao

Cao³

et al. 2008

Tissue Antigens

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Twenty-eight novel human leukocyte antigen-B alleles are described: one B*07 (*0745), two B*08 (*0826 and *0831), one B*27 (*2731), four B*35 (*350106, *350402, *3566, and *3568), two B*37 (*370102 and *3711), two B*38 (*380102 and *3813), two B*39 (*3935 and *3939), one B*41 (*4108), one B*42 (*4209), two B*44 (*4444 and *4448), two B*48 (*480302 and *4815), one B*51 (*5140), one B*55 (*5523), one B*56 (*5617), two B*57 (*570103 and *5710), and three B*15 (*9505, *9510, and *9519). Sixteen of the variants are single-nucleotide substitutions from their most homologous allele, of which 10 result in amino acid changes (B*0745, *0831, *3813, *3935, *3939, *4815, *9505, *9509, *9510, and *9519) and 6 are silent substitutions. The remaining alleles (B*0826, *2731, *3566, *3568, *3711, *4108, *4209, *4444, *4448, *5140, *5523, *5617, and *5710) differ from their most similar alleles by two to seven nucleotides substitutions, altering from one to five amino acids.

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“…All HLA‐A, ‐B, ‐C, and ‐DRB1 loci were typed using LABType reverse‐sequence‐specific oligonucleotide kits (One Lambda, Canoga Park, CA). New alleles were isolated by locus‐specific amplifications followed by sequencing with allele‐specific primers, except allele Cw*0734 of BY00073 was isolated by DNA cloning (3). Polymerase chain reaction and sequencing primers used can be found at http://www.dodmarrow.com and in previous publications (8–11).…”

Section: Cells With Novel Allelesmentioning

confidence: 99%

“…Of special note, three alleles, A*3211Q, B*3938Q, and B*4607N, carry alterations at codon 164. Codon 164 in HLA‐A, ‐B, and ‐C genes encodes cysteine [codons TGC in most alleles or TGT in B*570103 (3)]. Based on the crystal structure of HLA‐A2, this residue in the α‐helix is involved in a disulfide bond with the cysteine encoded at 101 in a β‐strand (4).…”

Section: Cells With Novel Allelesmentioning

confidence: 99%

Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries

Tang

Hou

et al. 2006

Tissue Antigens

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Based on unusual probe hybridization patterns, two human leukocyte antigen (HLA)-A, five HLA-B, and two HLA-C alleles (A*240208, A*3211Q; B*1822, B*3938Q, B*4606, B*4607N, B*5139; Cw*0321, Cw*0734) were identified in individuals from the Singapore Bone Marrow Donor Program and Singapore Cord Blood Bank. Eight of the nine alleles encode amino acid substitutions altering the antigen-binding region including three alleles with changes altering a cysteine at codon 164 (A*3211Q, B*3938Q, B*4607N). This substitution either eliminates a key disulfide bond or results in a stop codon, both likely affecting the expression of the HLA molecules. Only one allele (A*240208) carries a synonymous substitution.

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Twenty‐three novel HLA‐B alleles identified during intermediate‐resolution testing

Cited by 13 publications

References 5 publications

Nonfrequent but well‐documented, rare and very rare HLA alleles observed in the Croatian population

Nonfrequent but well‐documented, rare and very rare HLA alleles observed in the Croatian population

Expanding diversity at the HLA‐B locus: 28 novel HLA‐B alleles

Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries

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