Twenty-seven cases of adverse reaction in postoperative chemotherapy of breast cancer treated with acupoint catgut-embedding therapy

Meng, Shan; Lu, J.

doi:10.1016/s1003-5257(12)60031-2

Cited by 2 publications

(6 citation statements)

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“…In total, there were 51 studies remaining for full manuscript review, of which 41 studies were excluded due to the following reasons: different target population (n = 17), study protocols (n = 2), non-relevant outcomes (n = 21), non-RCT study design (n = 1). Finally, ten studies 29-38 were included for further qualitative and quantitative analyses. The PRISMA flow diagram of the review process is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…For the item of blinding of the outcome assessment, four 29,33,36,38 were classified as having low risk, and one had high risk. In terms of how the studies addressed incomplete outcome data, 8 studies [29][30][31][32][33][34][35]38 were classified as having low risk with reported rates of follow-up and withdrawal, and the remaining 2 had high risk. Seven studies 29,30,32,34,[36][37][38] had a low risk of selective reporting.…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

“…In terms of how the studies addressed incomplete outcome data, 8 studies [29][30][31][32][33][34][35]38 were classified as having low risk with reported rates of follow-up and withdrawal, and the remaining 2 had high risk. Seven studies 29,30,32,34,[36][37][38] had a low risk of selective reporting. And also, 2 studies 37,38 had low risk of bias with respect to other sources of bias.…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

“…In total, there were 51 studies remaining for full manuscript design (n = 1). Finally, ten studies [29][30][31][32][33][34][35][36][37][38] were included for further qualitative and quantitative analyses. The PRISMA flow diagram of the review process is presented in Figure 1.…”

Section: Study Selectionmentioning

confidence: 99%

“…Papers were published between 2012 and 2019. Most were carried out in China [30][31][32][33][34][35][36][37][38] ; only one took place in Australia. 29 The interventions used different types of acupuncture, including 2 with manual acupuncture, 2 trials with electroacupuncture, 2 with acupoint catgut embedding, and 4 moxibustion.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Effectiveness of Acupuncture in Relieving Chemotherapy-induced Leukopenia in Patients With Breast Cancer: A Systematic Review With A Meta-Analysis and Trial Sequential Analysis

Shih

Kung

et al. 2021

Integr Cancer Ther

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Background: Breast cancer is one of the most common cancers and a major cause of death in women worldwide. Chemotherapy is mainly used to treat and control the progression of breast cancer. Leukopenia is the most common side effect of chemotherapy which may decrease immune function and further lead to serious fatal infections. The purpose of this study was to evaluate the effect of acupuncture on regulating hematopoietic function in chemotherapy-induced leukopenia among patients with breast cancer. Methods: PubMed, Embase, Cochrane Library, CINAHL Plus, Web of Science, and Chinese articles in the Airiti Library and China National Knowledge Infrastructure (CNKI) databases were searched to August 2021 for papers to include in a systematic review and meta-analysis. A random-effects model was applied. The effect size was calculated by Hedges’ g. Heterogeneity was determined using Cochran’s Q test. Moderator analyses were performed to examine potential sources of heterogeneity. A trial sequential analysis (TSA) was conducted to determine whether the current sample size was sufficient. Results: Ten randomized controlled trials involving 650 participants were eligible for inclusion. Analysis by the random-effects model showed a significant effect by acupuncture of ameliorating leukopenia during chemotherapy. Levels of white blood cells (WBCs) were increased (Hedges’ g = 0.70, P < .001, I2 = 34%), neutrophil counts (Hedges’ g = 0.80, P < .001, I2 = 0%) were significantly enhanced. Moreover, regardless of the manner through which acupuncture was applied, overall values of WBCs increased. Conclusions: The current meta-analysis supports acupuncture possibly ameliorating chemotherapy-induced leukopenia, as WBC and neutrophil values significantly increased after acupuncture in patients undergoing chemotherapy. Additionally, regardless of the type of acupuncture, values of WBCs increased. These findings are actionable and support both the clinical use of acupuncture to relieve chemotherapy-induced leukopenia and further research regarding the use of acupuncture in patients experiencing immunosuppression when undergoing chemotherapy. Trial Registration: PROSPERO-CRD42020215759.

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Section: Resultsmentioning

confidence: 99%