Twenty-nine years after carbon monoxide intoxication

Cognitive Severity-Specific Neuronal Degenerative Network in Charcoal Burning Suicide-Related Carbon Monoxide Intoxication

“…While it has been reported that people who survive initial CO insults usually recover within 6 months to 1 year, 44 evidence from cross-sectional, 14 , 28 longitudinal, 8 , 45 , 46 and the present study suggest long-lasting, and perhaps permanent, subtle to detectable neuroimaging changes. Of specific note, in our Group 1 patients without significant objective cognitive deficits, the structural changes were evidenced by diffuse decreases in FA and regional increases in AD.…”

Myocardial Injury and Long-term Mortality Following Moderate to Severe Carbon Monoxide Poisoning

“…In a cohort of 138 patients from the United Kingdom in the 1960s, overall mortality was 15% at 3-year follow-up, but not all patients could be traced. 18,19 Multiple studies document 1-to 6-month neurological outcomes following CO poisoning 6,7,[20][21][22][23][24] and several report long-term neurological outcome, [25][26][27][28][29][30] but none discuss mortality. The most well-designed clinical trial of hyperbaric oxygen therapy in acute CO poi-soning demonstrated improved neurological outcomes with hyperbaric oxygen at 6-week, 6-month, and 12-month follow-up, but mortality was not assessed.…”

Impaired mitochondrial respiration and protein nitration in the rat hippocampus after acute inhalation of combustion smoke

“…The recognized neurotoxic factors in combustion-smoke are carbon monoxide, hydrogen cyanide and toxicants, which in the brain tissue may combine and synergize with free radical-generating factors as well as hypoxia and acidosis, to perturb cellular homeostasis and precipitate brain injury (Hartzell, 1996; Rossi et al, 1996; Smith et al, 1996; Roohi et al, 2001; Alarie, 2002; Raub and Benignus, 2002; Stuhmiller et al, 2006). …”