Twenty-nail dystrophy of childhood

Hazelrigg, Donald E.

doi:10.1001/archderm.113.1.73

Cited by 32 publications

(20 citation statements)

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“…3,4 Since these original reports, most authors have used these terms in both children and adults. Our study confirms that trachyonychia may affect patients from all age groups.…”

Section: Discussionmentioning

confidence: 99%

Follow up of 12 patients with trachyonychia

et al. 2006

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A follow-up study was performed to determine the outcomes of all patients (five males and seven females, mean age 18.4 years) who were referred to a specialist nail clinic with trachyonychia. The average number of affected nails per patient was 8.8 fingernails and 6.2 toenails. None of our patients tested positive for onychomycosis. Nail biopsies were performed in two patients, revealing non-specific changes. Eight patients did not present with or develop accompanying skin or mucosal disease. Two patients presented with alopecia areata and two others with psoriasis. Of our patients, 50% showed total resolution or marked improvement in their nail disease within the first 6 years regardless of treatment.

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“…3,4 Since these original reports, most authors have used these terms in both children and adults. Our study confirms that trachyonychia may affect patients from all age groups.…”

Section: Discussionmentioning

confidence: 99%

Follow up of 12 patients with trachyonychia

et al. 2006

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“…Twenty-nail dystrophy (TND), ever since its initial description a little over two-and-a-half decades ago, has come to occupy pride of place as a recognized clinical entity. 1 It is an autosomal, dominant inherited, idiopathic, nail dystrophy recognized by excessive longitudinal striations and numerous superficial pits on the nails which have a distinctive rough, sandpaperlike appearance. The condition is apparent at birth, and has a tendency to progress slowly.…”

Section: Introductionmentioning

confidence: 99%

Twenty nail dystrophy trachyonychia: An overview

Sehgal¹

2007

The Journal of Dermatology

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Twenty nail dystrophy (TND) trachyonychia, a fascinating clinical condition, was brought to focus 25 years ago. Ever since, it has been sparingly reported. Nonetheless, the condition is well‐recognized and its diagnosis is made on the basis of clinical features characterized by onset in infancy/childhood, and occasionally in adults. The lesions are fairly representative, and are characterized by the alternating elevation and depression (ridging) and/or pitting, lack of luster, roughening likened to sandpaper, splitting, and change to a muddy grayish‐white color. Dystrophy is prominent. Several modes of occurrence have been described including an hereditary component. The confirmation of diagnosis is through microscopic pathology corresponding either to endogenous eczema/dermatitis, lichen‐planus like or psoriasic‐form. It is a self‐limiting condition and may occasionally require intervention.

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“…16 Trachyonychia has also been observed in alopecia areata, 17 atopic dermatitis, 18 and Down syndrome. 19 Tosti et al 16 have describe the pathogenesis of trachyonychia. The nail changes in trachyonychia occur primarily due to damage to the nail matrix.…”

Section: Discussionmentioning

confidence: 99%