Twenty-Four of Twenty-Seven Studies Show a Greater Incidence of Emesis Associated with Nitrous Oxide than with Alternative Anesthetics

Hartung, J. B.

doi:10.1097/00000539-199607000-00020

Cited by 49 publications

(4 citation statements)

References 25 publications

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“…Therefore, in this study, fentanyl citrate (1 mcg kg −1 ) was added to 8% sevoflurane during induction. Previous studies have demonstrated that sevoflurane, N 2 O and intraoperative opioid use increased the incidence of PONV (13)(14)(15)(16). The administration of midazolam and high concentration O 2 has been reported to reduce the incidence of PONV (17,18).…”

Section: Discussionmentioning

confidence: 99%

Acupuncture as an Antiemetic in Children who Underwent Adenoidectomy and/or Tonsillectomy

Özmert¹,

Salman²,

Sever³

et al. 2016

Turk J Anaesth Reanim

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Amaç: Postoperatif kusma genel anestezi sonrasında en sık karşıla-şılan problemlerden biridir. Etiyolojide pek çok faktörün tek başı-na veya birlikte etkili olduğu bilinmektedir. Akupunktur, Dünya Sağlık Örgütünün tamamlayıcı tedavi metodu olarak kabul ettiği bir medikal tekniktir. Burada çocuk hastalarda adenoidektomi ve/ veya tonsillektomi sonrasında görülen kusmanın tedavisi amacıyla Akupunktur deneyimimiz sunulmaktadır.Yöntemler: Çalışmaya genel anestezi altında adenoidektomi ve/ veya tonsillektomi uygulanan, 2-14 yaş arasında, ASA I-II, (n=70) hastalar dahil edildi. Hastalar çalışma ve kontrol grubu olarak, rastgele iki gruba ayrıldılar. Çalışma grubunda, akupunktur iğnesi intraoperatif dönemde 20 dakika P6 noktasında uygulandı. Gruplara postoperatif dönemde antiemetik herhangi bir tedavi verilmedi. Hastalar postoperatif dönemde grupları bilmeyen hemşireler tarafında takip edildi. Bulgular: Yaş, cinsiyet, girişim türü, anestezi süresi, girişim süresi, cerrahi uygulama ve ASA skorları göz önüne alındığında gruplar arasında istatistiksel olarak anlamlı farklılık saptanmadı. Grupların kusma sayıları karşılaştırıldığında ise anlamlı farklılık olduğu saptandı. Akupunktur uygulanan grupta kusma sıklığının diğer gruba göre 0,28 kat daha az olduğu görüldü.Sonuç: Çalışmamızın sonuçları, akupunktur uygulamasının postoperatif kusmayı azaltmada açık bir etkinliği olduğunu gös-termektedir. Akupunkturun rutin kullanımı postoperatif hasta konforuna katkıda bulunmanın yanısıra tedavi veya profilaksi amacıyla ilaç kullanımını azaltacaktır.Anahtar kelimeler: Akupunktur, postoperatif kusma, adenoidektomi, tonsillektomi Objective: Postoperative vomiting (POV) is one of the most common problems following general anaesthesia, and many factors, either solely or in combination, may play a role in aetiology. Acupuncture is a technique that the World Health Organization has accepted as a complementary treatment. This study presents our experience with acupuncture for POV treatment in a study of paediatric tonsillectomy cases. Methods:The study included ASA I-II patients (n=70) aged 2-14 years who underwent tonsillectomy and/or adenoidectomy under general anaesthesia. The patients were randomly divided into the following two groups: control and study group. In the study group, an acupuncture needle was intraoperatively applied to the P6 acupuncture point for 20 min. Antiemetics were not administered to either group because of the standard applications in the preoperative period. The patients were postoperatively evaluated by nurses who were unaware about the techniques used in either group.Results: No statistically significant difference was determined between the groups with regard to age, sex, nature of the operation, duration of anaesthesia, duration of the operation, surgical method and ASA scores. A statistically significant difference was determined between the groups with respect to vomiting rates. The acupuncture group presented with 0.28-times fewer vomiting episodes than the control group. Conclusion:The results of the stud...

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Section: Discussionmentioning

confidence: 99%

Acupuncture as an Antiemetic in Children who Underwent Adenoidectomy and/or Tonsillectomy

Özmert¹,

Salman²,

Sever³

et al. 2016

Turk J Anaesth Reanim

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“…In contrast to Watcha et al [21], an investigation by Larsson et al [8] revealed a lower incidence of emetic episodes in the propofol group despite the use of nitrous oxide (5%) compared to thiopentone and halothane (27%). It might be that omitting nitrous oxide in the propofol group would have led to a more excessive reduction of vomiting in the present study [27,28]. However, we chose to use nitrous oxide in our investigation in order to reduce the risk of awareness and to supply additive analgesia to propofol and inhalational anesthesia [28].…”

Section: P-valuementioning

confidence: 94%

Nausea and Vomiting After Strabismus-Surgery: A Randomized Comparison of Isoflurane, Enflurane, Sevoflurane and Propofol

Kranke¹,

Apfel²,

Papenfuß³

et al. 2009

Open Clin Trials J

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Abstract:Background: Previous studies reported that propofol anesthesia is an effective means of preventing postoperative nausea and vomiting (PONV) after different types of surgeries. The present analysis of a large antiemetic trial is intend to compare propofol versus isoflurane, enflurane or sevoflurane with respect to the incidences of PONV after strabismus surgery.Methods: 238 ASA I -III inpatients, aged 4-65 years were randomly assigned to receive either isoflurane (group I, n = 60), enflurane (group E, n = 59), sevoflurane (group S, n = 59) or propofol (group P, n = 60) for maintenance as a subgroup of a larger trial of factorial design to investigate interventions to reduce PONV. After opioid application, patients in the inhalational groups (group I, E and S) had anesthesia induced with thiopental, those in group P received propofol for induction. Tracheal intubation was facilitated with succinylcholine. Patients were ventilated with N 2 O/O 2 2:1. Incidence and severity of PONV as well as the need for antiemetic rescue treatment were studied during the first 24 hours after anesthesia. Paracetamol and tramadol was given to treat postoperative pain.Results: There were no significant differences between study groups with respect to patient demographics and risk factors for postoperative nausea and vomiting. Nausea was reported by 43%, 41%, 42% and 22% of patients in groups I, E, S and P, respectively (P = 0.043). The incidence of vomiting was 40%, 46%, 34% and 18% in groups I, E, S and P, respectively (P = 0.011). Conclusion:Patients anesthetized with propofol showed a significantly lower incidence of nausea and vomiting compared to volatile anesthetics, while there was no significant differences in emetogenicity between the volatile anesthetics.

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“…Omission of N 2 O significantly reduced PONV in several meta-analyses, [10][11][12][13] but the risk of intraoperative awareness was also increased. 12 In most meta-analyses, propofol was associated with a lower frequency of PONV when used for total iv anesthesia in the absence of N 2 O.…”

Section: Résultats : Aucune Différence Intergroupe N'a éTé Enregistrémentioning

confidence: 95%

Induction with sevoflurane-remifentanil is comparable to propofol-fentanyl-rocuronium in PONV after laparoscopic surgery

Yang

Choi

McChesney

et al. 2004

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To compare sevoflurane-remifentanil induction and propofol-fentanyl-rocuronium induction with regards to the frequency of moderate to severe postoperative nausea and vomiting (PONV) in the first 24 hr after laparoscopic day surgery.M Me et th ho od ds s: : After informed consent, 156 ASA physical status class I to III patients undergoing laparoscopic cholecystectomy or tubal ligation were randomized to either induction with sevoflurane 8%, N 2 O 67% and iv remifentanil 1 to 1.5 µg·kg -1 or induction with iv fentanyl 2 to 3 µg·kg -1 , propofol 2 mg·kg -1 , and rocuronium 0.3 to 0.5 mg·kg -1 . All patients received iv ketorolac 0.5 mg·kg -1 at induction and sevoflurane-N 2 O maintenance anesthesia with rocuronium as needed. PONV was treated with iv ondansetron, droperidol, or dimenhydrinate; postoperative pain was treated with opioid analgesics. Patients were followed for 24 hr with regards to PONV and pain. Intubating conditions, induction and emergence times, time to achieve fast-track discharge criteria, and drug costs were measured. R Re es su ul lt ts s: : No differences were seen between the two groups in their frequencies of 24-hr moderate to severe PONV and postoperative pain, or in their intubating conditions, induction and emergence times, and time to achieve fast-track discharge criteria. Patients undergoing sevoflurane-remifentanil induction received more morphine (11 mg vs 8 mg; P < 0.001) in the postanesthetic care unit. Sevoflurane-remifentanil induction resulted in similar anesthetic and total drug costs for both procedures.C Co on nc cl lu us si io on n: : We did not demonstrate any difference in PONV, pain, or anesthetic/recovery times or costs between the sevoflurane and propofol groups. Sevoflurane-remifentanil induction is a feasible technique for anesthetic induction. Objectif : Comparer l'induction avec sévoflurane-rémifentanil ou propofol-fentanyl-rocuronium quant à la fréquence de nausées et vomissements postopératoires (NVPO) de modérés à sévères pendant les 24 premières heures après une opération en chirurgie d'un jour sous laparoscopie. Méthode : Après avoir accordé leur consentement, 156 patients d'état

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Twenty-Four of Twenty-Seven Studies Show a Greater Incidence of Emesis Associated with Nitrous Oxide than with Alternative Anesthetics

Cited by 49 publications

References 25 publications

Acupuncture as an Antiemetic in Children who Underwent Adenoidectomy and/or Tonsillectomy

Acupuncture as an Antiemetic in Children who Underwent Adenoidectomy and/or Tonsillectomy

Nausea and Vomiting After Strabismus-Surgery: A Randomized Comparison of Isoflurane, Enflurane, Sevoflurane and Propofol

Induction with sevoflurane-remifentanil is comparable to propofol-fentanyl-rocuronium in PONV after laparoscopic surgery

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