Twenty-four hour variations of cystatin C and total cysteine proteinase inhibitory activity in sera from healthy subjects

Cimerman, Nina; Brguljan, Pika Meško; Krašovec, Marta; Šuškovič, Stanislav; Kos, Janko

doi:10.1016/s0009-8981(99)00196-5

Cited by 25 publications

(12 citation statements)

References 12 publications

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“…Age, body weight, and gender did not influence cystatin C concentration, suggesting no need to calculate ranges dependent on these variables. These findings are similar to those of human studies, [40][41][42] but contrary to those of one veterinary study. 39 However, no GFR measurements were performed in that veterinary study, 39 suggesting that the possible inclusion of early kidney disease could have impacted the results.…”

Section: Discussionsupporting

confidence: 82%

Four-Fraction Radiation Therapy for Macroscopic Soft Tissue Sarcomas in 16 Dogs

Lawrence

Forrest

Adams

et al. 2008

Journal of the American Animal Hospital Association

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A retrospective study of 16 dogs with macroscopic soft tissue sarcomas was performed to evaluate response to a four-fraction radiotherapy protocol (prescribed dose of 32 Gy). Radiation was well tolerated with minimal side effects. The overall response rate was 50%, with seven partial responses and one complete response. The median time to progression was 155 days, and the median survival time was 309 days. Coarsely fractionated radiation therapy may be a reasonable palliative option for dogs with unresectable soft tissue sarcomas, although the response is relatively short-lived.

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Section: Discussionsupporting

confidence: 82%

Four-Fraction Radiation Therapy for Macroscopic Soft Tissue Sarcomas in 16 Dogs

Lawrence

Forrest

Adams

et al. 2008

Journal of the American Animal Hospital Association

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“…It was reported in humans that Pl-cystatin C remained almost stable over a 24-h period in a group of eight clinically symptom-free, normally fed, volunteers, with slightly lower values at 20.00 and midnight, and higher values at 04.00 (Cimerman et al 2000). In the dog, a very signi¢cant increase in GFR has been reported after a proteinrich meal O' Connor and Summerhill 1976;Brown and Finco 1992), this e¡ect being more intense in normal dogs than in dogs with renal insu⁄ciency (mean increases of 47% and 21%, respectively).…”

Section: Discussionmentioning

confidence: 90%

Plasma Cystatin C in the Dog: Reference Values and Variations with Renal Failure

Braun

Perxachs

́CHEREAU³

et al. 2002

Comparative Clinical Pathology

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Cystatin C is a low-molecular-mass acid protein produced at a constant rate by all nucleated cells and cleared by glomerular ¢ltration. In human medicine it is considered to be a better indicator of renal failure than creatinine. Plasma (Pl-) cystatin C measurements in 179 clinically healthy dogs, using an immunoturbidimetric procedure for human cystatin C, showed a Gaussian distribution with an upper limit of 1.3 mg/l. There were no di¡erences between the sexes. Pl-cystatin C was slightly lower in 1^8-year-old adults than in younger or older dogs. It was also lower in dogs weighing less than 15 kg than in heavier ones. Meals produced a dramatic decrease in Pl-cystatin C that lasted for up to 9h. Pl-cystatin C was elevated in 98% of dogs with renal insu⁄ciency, even in some cases where the Pl-creatinine was normal. Cystatin C may therefore be a useful indicator of renal insu⁄ciency in clinically relevant dogs with borderline P1-creatinine values.

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“…This might indicate that CatB, CatL as well as CysC are released from tumor cells into the CF to a greater extent than the release of these compounds into the serum of cancer patients. In this way, CF values may give a better reflection of local changes of the ovarian tumor than levels of cathepsins and its inhibitors in serum, which also might be affected by the systemic response on malignant disease and circadian variations (Cimerman et al 1999, 2000). From a clinical perspective, preoperative aspiration of ovarian cyst fluid might cause iatrogenic metastasis of tumor cells, and ovarian cyst fluid can only be used as a source of biomarkers for predicting prognosis and response to therapy.…”

Section: Discussionmentioning

confidence: 99%

Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors

Kolwijck

Massuger

Thomas

et al. 2009

J Cancer Res Clin Oncol

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IntroductionIn cancer, an extracellular and membrane bound localization of cathepsins contribute to the invasion of tumor cells at the basement membrane.MethodsThis is the first study that explored levels of cathepsins B (CatB), L (CatL) and their inhibitor cystatin C (CysC) in the cystic fluid (CF) of ovarian tumors (n = 110).ResultsCF contained considerable amounts of CatB, CatL and CysC. Remarkable differences in CatB and CatL and CysC CF levels were found between different histopathological tumor subtypes. Levels of CatB and CysC were significantly higher in CF of malignant serous tumors compared to those found in benign serous tumors (p = 0.010 and p = 0.001 respectively), whereas levels of CatL were significantly higher in CF of malignant mucinous tumors compared to those found in benign mucinous tumors (p = 0.035). CatB and CysC showed a strong correlation in the group of patients with malignant serous tumors (p < 0.001; R = 0.921) suggesting that the increase in CatB might be balanced by a corresponding increase in CysC.ConclusionFurther studies are warranted to investigate cathepsins as possible prognostic biomarkers for the aggressiveness of ovarian cancer.

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Twenty-four hour variations of cystatin C and total cysteine proteinase inhibitory activity in sera from healthy subjects

Cited by 25 publications

References 12 publications

Four-Fraction Radiation Therapy for Macroscopic Soft Tissue Sarcomas in 16 Dogs

Four-Fraction Radiation Therapy for Macroscopic Soft Tissue Sarcomas in 16 Dogs

Plasma Cystatin C in the Dog: Reference Values and Variations with Renal Failure

Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors

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