Twenty-four Hour Pattern of the Episodic Secretion of Cortisol in Normal Subjects

Weitzman, Elliot D.; Fukushima, David K.; Nogeire, Christopher; Roffwarg, Howard P.; Gallagher, T. F.; Hellman, Louis M.

doi:10.1210/jcem-33-1-14

Cited by 1,166 publications

(518 citation statements)

References 1 publication

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“…Cortisol tended to decrease between 8:30 and 15 h ( p < 0.001), in agreement with its well-known circadian rhythm (Weitzman et al, 1971;Veldhuis et al, 1989;Dickmeis, 2009), and tended to increase with gestational age ( p = 0.002). From the coefficients of regression analysis, we found that, on average, 2.7 additional gestation days corresponded to more 3.4 nmol/L in the plasma cortisol, assuming everything else remains equal.…”

Section: Cortisolsupporting

confidence: 71%

Cortisol and anxiety response to a relaxing intervention on pregnant women awaiting amniocentesis

Ventura

Gomes

Carreira

2012

Psychoneuroendocrinology

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Section: Cortisolsupporting

confidence: 71%

Cortisol and anxiety response to a relaxing intervention on pregnant women awaiting amniocentesis

Ventura

Gomes

Carreira

2012

Psychoneuroendocrinology

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“…27,28 What is even more interesting is the difference in effect on BP during the daytime compared to night-time recordings. Growth hormone and cortisol are two important hormones with a circadian variation, 29 and insulin secretion is in part affected by this variation. 30 The haemodynamic changes observed in the present study could perhaps be a result of these circadian variations.…”

Section: Discussionmentioning

confidence: 99%

Transdermal oestrogen reduces daytime blood pressure in hypertensive women

et al. 1998

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The aim of this study was to investigate the acute effects of transdermally administered 17-␤-oestradiol on ambulatory blood pressure (BP) in hypertensive, postmenopausal women. Thirteen postmenopausal women with ongoing treatment for hypertension were included in this placebo-controlled, double-blind cross-over study. Ambulatory recordings of BP and heart rate were performed during 24 h on two occasions, separated by at least 1 week, after application of a patch containing either 100 g per 24 h 17-␤-oestradiol or placebo. Serum oestradiol was increased (PϽ0.001) during active treatment (139.2 ± 21.1 pg/ml) compared with the baseline postmenopausal levels recorded during placebo (40.5 ± 2.2 pg/ml). No rise in BP was found in office BP

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“…In addition, melatonin brings about vasoconstriction through the MT1 and vasodilation through the MT2 receptors (24). It lowers cortisol secretion (25) in the adrenal cortex, similar to the action shared with insulin (23). Moreover, human adipocytes, a major target tissue for insulin, express MT2 and have been shown to reduce expression of the insulin-dependent glucose transporter, Glut4, after melatonin stimulation (26).…”

Section: Melatonin and Its Functionmentioning

confidence: 99%

The role of melatonin in diabetes: therapeutic implications

Sharma

Singh

Ahmad

et al. 2015

Arch. Endocrinol. Metab.

107

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Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 pathway, which mobilizes Ca 2+ from organelles and, consequently increases insulin secretion. Both in vivo and in vitro, insulin secretion by the pancreatic islets in a circadian manner, is due to the melatonin action on the melatonin receptors inducing a phase shift in the cells. Melatonin may be involved in the genesis of diabetes as a reduction in melatonin levels and a functional interrelationship between melatonin and insulin was observed in diabetic patients. Evidences from experimental studies proved that melatonin induces production of insulin growth factor and promotes insulin receptor tyrosine phosphorylation. The disturbance of internal circadian system induces glucose intolerance and insulin resistance, which could be restored by melatonin supplementation. Therefore, the presence of melatonin receptors on human pancreatic islets may have an impact on pharmacotherapy of type 2 diabetes. Arch Endocrinol Metab.2015;59(5):391-9

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Twenty-four Hour Pattern of the Episodic Secretion of Cortisol in Normal Subjects

Cited by 1,166 publications

References 1 publication

Cortisol and anxiety response to a relaxing intervention on pregnant women awaiting amniocentesis

Cortisol and anxiety response to a relaxing intervention on pregnant women awaiting amniocentesis

Transdermal oestrogen reduces daytime blood pressure in hypertensive women

The role of melatonin in diabetes: therapeutic implications

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