Twenty-four-hour efficacy of preservative-free tafluprost for open-angle glaucoma patients, assessed by home intraocular pressure (Icare-ONE) and blood-pressure monitoring

Cho, Soon Young; Kim, Yong Yeon; Yoo, Chungkwon; Lee, Tae Eun

doi:10.1007/s10384-015-0413-1

Cited by 12 publications

(6 citation statements)

References 40 publications

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“…In glaucoma patients, the iCare HOME allowed detection of changes to intraocular pressure following initiation of treatment with a prostaglandin analog. Cho et al 38 investigated the effect of once-daily treatment with tafluprost 0.0015% ophthalmic solution on patients with primary open angle glaucoma, with iCare ONE self-tonometry, and found that intraocular pressure was significantly reduced following 2 weeks of treatment. This study suggests that intraocular pressure reduction and hence treatment effect could be measured following only a single day of treatment, with a slight further reduction on the second day.…”

Section: Discussionmentioning

confidence: 99%

Diurnal Intraocular Pressure Fluctuations with Self-tonometry in Glaucoma Patients and Suspects: A Clinical Trial

et al. 2018

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SIGNIFICANCEThis article shows that self-tonometry can provide robust measures of diurnal intraocular pressure (IOP) and also detect changes to IOP in response to treatment within a short period of monitoring. These advances in IOP monitoring may contribute to improved management of glaucoma patients and suspects.PURPOSEThe aim of this study was to prospectively investigate the utility of rebound self-tonometry performed over several weeks for detecting diurnal IOP fluctuations in glaucoma patients and suspects and also initial response to topical treatment in glaucoma patients.METHODSForty patients were recruited following glaucoma-specific examination. Subsequent to successful training with the iCare HOME tonometer, patients were instructed to measure IOP, in a sitting position, four times a day over 4 to 6 weeks. Date, time, laterality, and IOP downloaded from the tonometer and clinical examination data, including applanation IOP and corneal thickness, were analyzed. A user satisfaction survey was also administered at study completion. t Test and analysis of variance were used to compare groups and IOP across days. Pearson correlation was used to compare measurements to Goldmann applanation tonometry and IOP measurements from the first day/s to the overall mean IOP.RESULTSTwenty-seven patients (18 suspects and 9 glaucoma patients) completed data collection. Patients self-measured IOP on 118 (±29) occasions for 40 (±7.4) days. Two dominant patterns of fluctuation were revealed: peak IOP upon awakening (n = 11) and at midday (n = 13). Diurnal IOP measured in the first 7 days showed strong correlation to diurnal IOP across the entire study period (r2 = 0.82, P < .0001). Within 24 hours of treatment commencement (latanoprost 0.005% ophthalmic solution), IOP reduced from 23.9 (±5.2) to 16.1 (±2.6) mmHg. Overall, patients rated the instrument as easy to use, although difficulties with correct alignment were expressed.CONCLUSIONSRebound self-tonometry demonstrated utility for measuring diurnal IOP fluctuations in most patients, hence enhancing management of patient with or at risk of developing glaucoma.

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Section: Discussionmentioning

confidence: 99%

Diurnal Intraocular Pressure Fluctuations with Self-tonometry in Glaucoma Patients and Suspects: A Clinical Trial

et al. 2018

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“…[1][2][3] Medical treatment with prostaglandin analogs or surgical procedures, such as trabeculectomy are most commonly used to decrease IOP. [4][5][6][7] In general, operative treatment is indicated for cases in which sufficient reduction of IOP cannot be achieved with medical treatment alone. 8 As the ultimate goal of glaucoma treatment is the maintenance of visual function for the rest of the patient's life, many patients undergo long-term administration of glaucoma eye drops.…”

mentioning

confidence: 99%

Conjunctival Bacteria Flora of Glaucoma Patients During Long-Term Administration of Prostaglandin Analog Drops

Ohtani

Shimizu

Nejima

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the effects of the long-term use of prostaglandin analogs for glaucoma treatment on the indigenous flora of the conjunctiva.METHODS. Bacterial isolates were collected from the conjunctival sacs of 68 patients at Miyata Eye Hospital from February to September 2014, who had been receiving continuous monotherapy with prostaglandin analogs for glaucoma for at least 1 year. Minimum inhibitory concentrations of levofloxacin, gatifloxacin, moxifloxacin, cefmenoxime, tobramycin, chloramphenicol, and erythromycin against the isolates were measured to determine susceptibility. RESULTS.The positive culture rate in all cases was 90.5% (57/63 eyes), and a total of 79 bacterial strains were isolated. The isolated bacteria included aerobic gram-positive cocci (8% Staphylococcus aureus and 41% Staphylococcus epidermidis), coagulase-negative staphylococci (5%), Streptococcus spp. (1%), Corynebacterium spp. (4%), gram-negative bacteria (4%), and the facultative anaerobe Propionibacterium acnes (33%). The positive culture rates for patients using 0.005% latanoprost (Xa group) and 0.004% travoprost (Tz group) were 88.9% and 92.6%, respectively, with no statistically significant difference in the composition of isolated bacteria between groups. Methicillin-resistant S. epidermidis (MRSE) was significantly more frequently isolated in the Xa group. The antimicrobial susceptibility rates of S. epidermidis were significantly lower in the Xa group for levofloxacin, gatifloxacin, moxifloxacin, and tobramycin.CONCLUSIONS. The indigenous flora may be affected by the long-term use of prostaglandin analogs. The higher incidence of MRSE in the Xa group should be considered during the longterm, continuous administration of eye drops, such as in glaucoma treatment.

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“…In addition, postoperative application of brinzolamide combined with timolol eye drops in the treatment of NVG patients can effectively reduce IOP and control its uctuations, and these effects are mainly achieved by regulating the balance of angiogenesis promoting/inhibiting factors, VEGF and its receptors. [20][21]. In this study, it was found that the visual acuity level of the patients was signi cantly increased after treatment, and the levels of VEGF and its receptors in the serum were signi cantly decreased, and the above situation is more obvious in the patients of the observation group, suggesting that the obvious curative effect of Ta oprost on patients with primary open angle glaucoma may be related to the improvement of vascular endothelial functional molecules.…”

Section: Of Changes In Hemorheological Parameters After Ta Uprost Tre...mentioning

confidence: 60%

Effect of Tafluprost on Endothelial Function-related Molecules and Hemorheological Parameters in Patients with Primary Open-angle Glaucoma

Liu

Nie

et al. 2023

Preprint

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Objectives This study analyzed the effect of tafluprost on endothelial function-related molecules and hemorheological parameters in patients with primary open-angle glaucoma, and provided reference for clinical treatment.Methods Patients with primary open-angle glaucoma diagnosed and treated in our hospital from January 2018 to March 2019 were selected as the research subjects. 70 patients (140 eyes) were randomly divided into two groups: control group (n = 35 cases, 70 eyes) and observation group (n = 35 cases, 70 eyes). The patients in the control group received timolol maleate eye drops, and the patients in the observation group received tafluprost eye drops. The clinical effects of the two groups of patients were analyzed, and the changes of endothelial function-related molecule [vascular endothelial growth factor (VEGF) level] were detected before and after treatment, and the changes of blood rheology parameters before and after treatment in the two groups were analyzed.Results The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the visual acuity of the two groups was significantly increased while the intraocular pressure (IOP) was significantly decreased (P < 0.05), and the levels of VEGF and its receptors in serum were significantly increased (P < 0.05), End diastolic velocity (EDV) and peak systolic velocity (PSV) levels of central retinal artery (CRA) and short posterior ciliary artery (SPCA) were significantly increased while resistance index (RI) level was significantly decreased (P < 0.05). Compared with the control group, the above indicators in the observation group had more significant changes (P < 0.05).Conclusions Tafluprost has obvious clinical effect on patients with primary open-angle glaucoma, and can significantly improve abnormal hemorheological parameters and abnormal levels of endothelial function molecules.

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Twenty-four-hour efficacy of preservative-free tafluprost for open-angle glaucoma patients, assessed by home intraocular pressure (Icare-ONE) and blood-pressure monitoring

Abstract: Icare-ONE enables glaucoma patients to measure their own diurnal IOP fluctuations. Patient-measured Icare-ONE IOP readings showed that PF tafluprost effectively reduced diurnal IOP in eyes with POAG.

Cited by 12 publications

References 40 publications

Diurnal Intraocular Pressure Fluctuations with Self-tonometry in Glaucoma Patients and Suspects: A Clinical Trial

Diurnal Intraocular Pressure Fluctuations with Self-tonometry in Glaucoma Patients and Suspects: A Clinical Trial

Conjunctival Bacteria Flora of Glaucoma Patients During Long-Term Administration of Prostaglandin Analog Drops

Effect of Tafluprost on Endothelial Function-related Molecules and Hemorheological Parameters in Patients with Primary Open-angle Glaucoma

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