Twenty-four hour ambulatory blood pressure: a sample from a normal British population

Manning, Gillian; Rushton, Lesley; Millar‐Craig, M.W.

doi:10.1038/sj.jhh.1000564

Cited by 12 publications

(19 citation statements)

References 5 publications

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“…In the HARVEST study, among never-treated borderline to mild young hypertensives (n=1062), nocturnal BP nondipping was present in 31% 18. One study of a British population published in 1998 found that among 265 healthy, normotensive volunteers who underwent office and ambulatory BP measurements, 17% were nondippers 19. Compared to the participants in our study, those in the British study were slightly older with a mean age of 39 years.…”

Section: Discussioncontrasting

confidence: 54%

Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA study

Viera

Zhu

Hinderliter

et al. 2011

Journal of the American Society of Hypertension

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Nondippers (people whose sleep systolic blood pressure (SBP) fails to decrease >10% from daytime SBP) have increased risk of cardiovascular disease. The prevalence of nondipping in younger adults has not been well-studied, nor has its value for predicting hypertension. We examined the prevalence of nondipping in a sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. We used Cox regression to estimate the hazard ratio (HR) conferred by nondipping for incident prehypertension or hypertension (preHTN/HTN) over 15 years. Of the 264 non-hypertensive participants at baseline, 118 (45%) were nondippers. Blacks were more likely than Whites to be nondippers (52% vs 33%, p=0.004). The incidence rate of preHTN/HTN was 29.2/1000 person-years among dippers and 36.2/1000 person-years among nondippers. Compared to those in the lowest quartile of nighttime to daytime SBP, those in the highest quartile were more likely to develop preHTN/HTN (HR 1.61; p =0.06), but this relationship was attenuated after adjustment (HR 1.34; p =0.27). Our results demonstrate that nondipping is common in young, nonhypertensive adults, and is more common in Blacks than Whites. Nondipping might predate a meaningful clinically detected increase in BP in some people, but more research in larger study samples is needed.Keywords diurnal blood pressure; blood pressure dipping; hypertension

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Section: Discussioncontrasting

confidence: 54%

Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA study

Viera

Zhu

Hinderliter

et al. 2011

Journal of the American Society of Hypertension

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“…It has been consistently shown that ambulatory BP measurements are more powerful to predict LVH than is office BP. 26,27 However, multiple subgroup analyses with and without adjustment for BP levels failed to show in the present study an association between the GNB3 poly- …”

Section: Discussioncontrasting

confidence: 38%

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function

et al. 2002

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Abstract-The G protein ␤ 3 -subunit C825T polymorphism results in a truncated splice variant protein that is associated with enhanced transmembrane signaling, increased proliferative activity, and arterial hypertension. The aim of the present study was to further investigate the association of this polymorphism with left ventricular (LV) structure and function. A total of 2052 individuals from a large-scale population-based sample were investigated for the G protein ␤ 3 -subunit C825T polymorphism and echocardiographic parameters of LV structure and function. Complete genotyping and echocardiographic data were available in 1720 individuals (829 men and 891 women). The mean LV mass indices in men with CC (nϭ384) and TT (nϭ84) genotypes were 98.3Ϯ1.2 g/m 2 and 100.0Ϯ2.8 g/m 2 , respectively (Pϭ0.64). In women, the corresponding values were 83.1Ϯ1.0 g/m 2 for the CC genotype (nϭ397) and 83.8Ϯ2.1 g/m 2 for the TT genotype (nϭ91, Pϭ0.32). Likewise, LV dimensions or parameters of the diastolic function and serologic markers of LV mass were not associated with the C825T variant. Finally, multivariate analyses accounting for potentially confounding factors failed to show any influence of this polymorphism on echocardiographic parameters. In conclusion, we were not able to confirm the previously published associations of the G protein ␤ 3 -subunit C825T polymorphism with LV structure and diastolic function.

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“…The methods of OBP and awake ABP measurements in the selected studies are shown in Supplemental Table 1 (S1). In the meta-analysis of the 23 studies of adults (N=10249) 7,15,16,20–25,28,29,31–38,40–42,44 , office systolic/diastolic BP [mean (95 % confidence intervals)] was 1.8 (1.8–1.9)/1.9 (1.8–2.0) mmHg higher than awake ABP (both P<0.001), but in the parallel analysis of the 5 studies of children and youth (N=1829) 26,27,30,39,43 , awake ABP was 8.4 (8.2–8.5)/7.0 (6.9–7.1) mmHg higher than office BP (both P<0.001).…”

Section: Resultsmentioning

confidence: 99%

Age and the difference between awake ambulatory blood pressure and office blood pressure

Ishikawa

Edmondson

et al. 2011

Blood Pressure Monitoring

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Background Ambulatory blood pressure (ABP) is a better predictor of adverse cardiovascular events than office BP (OBP). Due to the extensive literature on the “white coat effect”, it is widely believed that ABP tends to be lower than OBP, with statements to this effect in JNC VII. However, recent evidence suggests that the difference varies systematically with age. Methods We searched PubMed to identify population studies, published before April 2009, which assessed office BP and either ABP or home BP. Because of significant heterogeneity in the outcomes, random effects models were used for the meta-analyses. Results OBP increased with age more steeply than awake ABP. OBP became higher than awake systolic/diastolic ABP at the age of 51.3/42.7 years in men (13 studies, N=3562) and 51.9/42.3 years in women (11 studies, N=2585). In the data in which OBP and HBP were measured (8 studies, N=4916), OBP was higher than HBP at all ages. In the data in which OBP, awake ABP and HBP were all measured (2 studies, N=895), awake ABP was higher than HBP at younger ages, becoming similar at the older age. Conclusion OBP tends to be higher than awake ABP only after age 50 for systolic and age 45 for diastolic, but is lower than ABP at younger ages; in contrast OBP tends to exceed HBP at all ages.

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Twenty-four hour ambulatory blood pressure: a sample from a normal British population

Cited by 12 publications

References 5 publications

Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA study

Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA study

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function

Age and the difference between awake ambulatory blood pressure and office blood pressure

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Twenty-four hour ambulatory blood pressure: a sample from a normal British population

Cited by 12 publications

References 5 publications

Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA study

Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA study

Relation of the G Protein β 3 -Subunit Polymorphism With Left Ventricle Structure and Function

Age and the difference between awake ambulatory blood pressure and office blood pressure

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Product

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Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function