Twenty-four-hour ambulatory blood pressure measurement in a primigravid population

White coat hypertension and pregnancy outcome

“…Several studies have set normal reference values for ABPM in pregnancy, 14,18,19,22 others have defined WCH in pregnancy as a mean 24-h diastolic BP of 85 mm Hg, 21 as we did, or as at least a 5 mm Hg difference in diastolic or systolic readings in the averaged ABPM from the readings obtained in the clinic. 23 Interestingly, Churchill and Beevers 14 who used the Spacelabs 90207 in a cohort of normal pregnant women at a similar gestational week to ours noted similar values to the cut-off points in our study.…”

“…16,17 The information on the difference between clinic and ambulatory BP in pregnancy is controversial, and on WCH in pregnancy, minimal. According to different studies, clinic BP is higher, 18 equal to, 19 and lower 20 than awake ambulatory BP. These discrepancies may reflect the different methods of determining clinic BP (by a clinician vs a member of the research team under more relaxed conditions), device error or different levels of daily activity.…”

Endothelial NO Synthase Genotype and Risk of Preeclampsia

“…2 Systemic arteriolar vasodilatation, probably dependent on endothelial NO, 3,4 is responsible for the hemodynamics of the first half of the pregnancy (increased blood volume and cardiac output and decreased blood pressure). 5,6 Deficiencies in the vasodilatory, antithrombotic, and atheroprotective effects of NO 7,8 have been implicated in the pathogenesis of cardiovascular disease, for which preeclampsia is also a risk factor. 9,10 Therefore, the gene that encodes endothelial NO synthase (eNOS), the enzyme that regulates endothelial NO availability, is a candidate gene for preeclampsia.…”

I Diretrizes para o Uso da Monitorização Residencial da Pressão Arterial

“…Igualmente, observa-se diminuição linear da pressão arterial sistólica, diastólica e média até a 22 a semana de gestação, seguida por aumento progressivo até o dia do parto [17][18][19] . Variações da pressão arterial na pré-eclâmpsia têm sido reconhecidas há muito tempo.…”