Twenty-four hour ambulatory blood pressure monitoring

Lüders, Stephan; Iw, Franz; Hilgers, K. F.; Homuth, Volker; Mengden, Thomas; Tholl, U; Eckert, Siegfried; Sanner, Bernd

doi:10.1055/s-2005-922054

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…ABPM had to be performed according to the society's recommendations [10]. ABPM was performed at randomization, and after 12 and 36 months, with validated devices, in the majority SpaceLabs 90207 or 90217.…”

Section: Ambulatory Blood Pressure Monitoringmentioning

confidence: 99%

The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure – a prospective, randomized, controlled prevention trial of the German Hypertension League

Lüders

Schrader²,

Berger³

et al. 2008

Journal of Hypertension

189

108

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There is now good clinical evidence that patients with high-normal blood pressure (prehypertension) are more likely to progress to manifest hypertension than patients with optimal or normal blood pressure. Additional ambulatory blood pressure monitoring seems to be essential to achieve correct diagnosis. Treatment of patients with high-normal office blood pressure with the angiotensin-converting enzyme inhibitor was well tolerated, and significantly reduced the risk of progression to manifest hypertension.

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Section: Ambulatory Blood Pressure Monitoringmentioning

confidence: 99%

The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure – a prospective, randomized, controlled prevention trial of the German Hypertension League

Lüders

Schrader²,

Berger³

et al. 2008

Journal of Hypertension

189

108

View full text Add to dashboard Cite

show abstract

“…Fourth, because ABPM was not mandatory, the number of patients with both OBPM and ABPM is limited to about 25% of all patients. Because ABPM is usually performed in clinical practice in patients whose BP is difficult to control, ABPM may not be completely representative for the total OBPM population 12. This may explain the high proportion of nondipping patients.…”

Section: Discussionmentioning

confidence: 99%

Office and ambulatory blood pressure control with a fixed-dose combination of candesartan and hydrochlorothiazide in previously uncontrolled hypertensive patients: results of CHILI CU Soon

Mengden¹,

R²,

Bramlage³

2011

VHRM

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BackgroundFixed-dose combinations of candesartan 32 mg and hydrochlorothiazide (HCTZ) have been shown to be effective in clinical trials. Upon market entry we conducted a noninterventional study to document the safety and effectiveness of this fixed-dose combination in an unselected population in primary care and to compare blood pressure (BP) values obtained during office measurement (OBPM) with ambulatory blood pressure measurement (ABPM).MethodsCHILI CU Soon was a prospective, noninterventional, noncontrolled, open-label, multicenter study with a follow-up of at least 10 weeks. High-risk patients aged ≥18 years with previously uncontrolled hypertension were started on candesartan 32 mg in a fixed-dose combination with either 12.5 mg or 25 mg HCTZ. OBPM and ABPM reduction and adverse events were documented.ResultsA total of 4131 patients (52.8% male) with a mean age of 63.0 ± 11.0 years were included. BP was 162.1 ± 14.8/94.7 ± 9.2 mmHg during office visits at baseline. After 10 weeks of candesartan 32 mg/12.5 mg or 25 mg HCTZ, mean BP had lowered to 131.7 ± 10.5/80.0 ± 6.6 mmHg (P < 0.0001 for both comparisons). BP reduction was comparable irrespective of prior or concomitant medication. In patients for whom physicians regarded an ABPM to be necessary (because of suspected noncontrol over 24 hours), ABP at baseline was 158.2/93.7 mmHg during the day and 141.8/85.2 mmHg during the night. At the last visit, BP had significantly reduced to 133.6/80.0 mmHg and 121.0/72.3 mmHg, respectively, resulting in 20.8% being normotensive over 24 hours (<130/80 mmHg). The correlation between OBPM and ABPM was good (r = 0.589 for systolic BP and r = 0.389 for diastolic BP during the day). Of those who were normotensive upon OBPM, 35.1% had high ABPM during the day, 49.3% were nondippers, and 3.4% were inverted dippers. Forty-nine adverse events (1.19%) were reported, of which seven (0.17%) were regarded as serious.ConclusionCandesartan 32 mg in a fixed-dose combination with either 12.5 mg or 25 mg HCTZ is safe and effective for further BP lowering irrespective of prior antihypertensive drug class not being able to control BP.

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“…B. Schwindel) -besonders bei älteren Patienten -durch übermäßige Blutdrucksenkung vermutet werden, die durch Gelegenheitsselbstmessung nicht geklärt werden können; oder 5) eine therapierefraktäre Hypertonie vorliegt[22]. Erkrankungen, die mit erhöhten nächtlichen Blutdruckwerten einhergehen sind Diabetes, chronische Niereninsuffizienz, linksventrikuläre Hypertrophie, Schlafapnoe sowie die Schwangerschaftshypertonie.…”

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Chronobiologie des Blutdrucks und Chronopharmakotherapie der arteriellen Hypertonie

Bramlage

Schunkert

2012

Dtsch med Wochenschr

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Arterial blood pressure is subject to a circadian rhythm that results in a fall of blood pressure during the night. In patients with diabetes, renal insufficiency, left-ventricular hypertrophy, sleep apnea, hypertension of pregnancy, and different forms of secondary hypertension a nocturnal fall of blood pressure is even abandoned or reverted. Diagnosis is made using 24-h blood pressure measurement, which is however used not frequently enough for a clinical assessment or adjustment of therapy. An adaption of the selection or the time of administration of antihypertensive drugs with respect to the circadian rhythm is beneficial to control blood pressure and reduce cardiovascular morbidity. This is particularly true for patients with an a non- or inverted dipping blood pressure pattern, in which the bedtime dosing may result in a normalization of blood pressure and restoration of a normal circadian rhythm. The present manuscript reviews the chronopharmacotherapy of arterial hypertension and grant practical recommendations for their translation into clinical practice.

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Twenty-four hour ambulatory blood pressure monitoring

Cited by 10 publications

References 16 publications

The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure – a prospective, randomized, controlled prevention trial of the German Hypertension League

The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure – a prospective, randomized, controlled prevention trial of the German Hypertension League

Office and ambulatory blood pressure control with a fixed-dose combination of candesartan and hydrochlorothiazide in previously uncontrolled hypertensive patients: results of CHILI CU Soon

Chronobiologie des Blutdrucks und Chronopharmakotherapie der arteriellen Hypertonie

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