Twenty-four hour ambulatory blood pressure in the Hypertension Optimal Treatment (HOT) study

Abstract

In conclusion, in the HOT study, treatment reduced not only office but also ambulatory blood pressure throughout the 24 h. The reduction was less marked for ambulatory than for office blood pressure.

Protective effects of renin–angiotensin blockade beyond blood pressure control

“…For example, the correlation coefficient values at the fourth year of treatment were 0.28 and 0.16 for systolic and diastolic blood pressure, respectively. 3 Similar results have been obtained in other trials such as the Hypertension Optimal Treatment (HOT), 4 the International Nifedipine GITS study Intervention as a Goal in Hypertension Treatment (INSIGHT) 5 and the Plaque Hypertension Lipid-Lowering Italian Study (PHYLLIS). 6 Blood pressure control and cardiovascular outcome…”

Twenty-four-hour ambulatory blood pressure measurement in clinical practice and research: a critical review of a technique in need of implementation

“…Based on these findings it is likely that more of the benefits of ramipril in HOPE may be related to BP reduction (especially during night-time) than what was explained by the effects on OBP seen in both the main study and this study. The effects on cardiovascular morbidity and mortality seen with ramipril in the HOPE study may relate to effects on BP patterns over the 24-h period Twenty-four hour ambulatory blood pressure in the Hypertension Optimal Treatment (HOT) study [104] At baseline 24 h average blood pressures were significantly and markedly lower than OBP.…”

“…As a consequence, ancillary studies using ABPM have often enrolled small numbers that are unrepresentative of the main study population or they lack a baseline ABPM, making it impossible to determine the transition from no treatment at baseline to the effect of full-dose medications and thereby limiting greatly the conclusions of the ancillary studies [112]. The major outcome studies that had ABPM ancillary studies are listed in Table 3 [14,59,62,[103][104][105][113][114][115][116][117][118]. These studies provide a wealth of information the analysis of which is beyond the scope of this review but, whatever the strengths and shortcomings of these studies may be, one message emerges clearly and that is the superiority of nocturnal blood pressure, whether it be the nondipping or morning surge pattern or both, in predicting outcome.…”

“…Ambulatory blood pressure measurement has been used as a marker of cardiovascular morbidity and mortality in a number of major studies to provide data on the effect of antihypertensive drug medication on outcome that cannot be provided by conventional BP measuring techniques [101][102][103][104][105]. This has been because of the evidence from a number of studies showing not only that ABPM parameters may be more E. O'Brien | Review: ABPM in practice and research accurate predictors of cardiovascular risk but that optimal antihypertensive therapy should provide BP control over the full 24-h period and that control of BP may be particularly relevant in certain periods of the 24-h profile, such as in the nocturnal and matinal windows [14,46,62,[106][107][108][109][110][111].…”

Circadian variations in blood pressure in health and disease: implications for patient management

“…The HOT (Hypertension Optimal Treatment) study similarly had a 24-hour ABPM substudy 83 illustrating the converse difference between in-office and ABPM values on antihypertensive study. In this study, patients underwent both office and 24-hour monitoring and were treated for a median period of 2 years.…”