Twenty‐four hour ambulatory antroduodenal manometry in normal subjects (co‐operative study)

Abstract

Circadian antroduodenal motor activity was studied in 40 normal subjects by means of a portable recording system consisting of a computerized data logger and a probe with microtransducers. The quantitative and qualitative characteristics of contraction events during the interdigestive and digestive periods, as well as during the awake and asleep periods, were analysed. The composition and timing of meals and night recumbence were standardized. In spite of the high interindividual variability in motor parameters, significant differences in the characteristics of interdigestive and digestive periods between waking and sleep states were found. This paper confirms the existence of a circadian variation in antroduodenal motor activity and provides reference values from a large series of normal subjects that can be used for statistical comparisons with those obtained from patients recorded with the same method.

Measurement of, and Some Reasons for, Differences in Eating Habits Between Night and Day Workers

“…During the ''lunch'' break in the middle of the night shift external factors (inadequate canteen facilities, poor facilities for sitting down and enjoying a meal) or internal factors (individual not feeling hungry or individual not finding the available foods palatable) might affect food intake. An unadjusted body clock might contribute to the internal factors, with rhythms of the gastrointestinal tract activity and hypothalamic feeding centers timed inappropriately for night eating (Auwerda et al, 2001;Bortolotti et al, 2000;Keller et al, 2001;Rowland et al, 1996;Stanley et al, 1989;Strubbe and van Dijk, 2002;Vener et al, 1989;Waterhouse et al, 1999). Whatever the reason(s), night workers commonly admit to altered eating habits (Lennernas et al, 1995;Nikolova et al, 1990;Tepas, 1990) in terms of both the distribution and types of meals consumed.…”

Comparison of the Effect of Azithromycin Versus Erythromycin on Antroduodenal Pressure Profiles of Patients with Chronic Functional Gastrointestinal Pain and Gastroparesis

“…After a 6-h baseline manometric recording and 2-h fed state, the therapeutic (postprandial) portion of the manometric study is performed with each drug, erythromycin (EES) and azithromycin (AZI). Four hours of recording is performed after administration of each drug with EES given first followed by AZI phases of the MMC according to accepted criteria [26][27][28]. Contractions in the antrum were defined by changes in amplitude from baseline of more than 10 mmHg (1.3 kPa) and durations of more than 1 s. Then the amplitude and duration of the contractions were analyzed using GastroTrac software and by visual inspection.…”

Gastroparesis Refractory to Prokinetics: Neuromuscolar Unresponsiveness or Faulty Bioavailability of the Drug?

“…In these 6 weeks of treatment the patient lost another 2 kg of body weight, reaching 48 kg. At this point an ambulatory 24-hr gastrointestinal manometric study with a portable apparatus was performed for 2 days following a technique described elsewhere (9). During the first day marked hypomotility during both the interdigestive and the digestive periods was observed, with the occurrence of three activity fronts (phases III) of the migrating motor complex (MMC) during the night and early in the morning ( Figure 1A).…”