Twenty-Five Years After Chernobyl: Outcome of Radioiodine Treatment in Children and Adolescents With Very High-Risk Radiation-Induced Differentiated Thyroid Carcinoma

Abstract

Experience of a large, very high-risk pediatric cohort with radiation-induced differentiated thyroid carcinoma suggests that even when such disease is advanced and initially suboptimally treated, response to subsequent RIT and final outcomes are mostly favorable.

Surgical management of well-differentiated thyroid carcinoma in children and adolescents: 33 years of experience of a single institution in Serbia

“…The latency period between radiation exposure and developing a thyroid carcinoma is between 10 and 20 years [18,19], but after Chernobyl nuclear reactor explosion in 1986, the latency period was significantly shorter, 5 years [20][21][22][23].…”

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

“…As children with pulmonary metastases may have diffuse RAI uptake in the lungs, there is a real concern about treatment-induced pulmonary fibrosis (57, 258,[345][346][347][348]. In these cases, administering lower 131 I activities and employing dosimetry should be considered to limit radiation exposure to the nontarget normal lung parenchyma (244)(245)(246)347,349) (Section C14).…”

Bone mineral density in treated at a young age for differentiated thyroid cancer after Chernobyl female patients on TSH-suppressive therapy receiving or not Calcium-D3 supplementation

“…Aside TSH-suppressive therapy, another condition affecting Initial management of DTC included surgical treatment (total thyroidectomy in 112 patients, hemithyroidectomy in 12 patients). RAI was performed in 104 cases (mean total 131 I activity 9.89±8.23 GBq, min 2.20, max 40.9 GBq) according to the standard protocol [18].…”

“…Negative whole body scintigraphy in combination with low detectable TG (1-10 μg/L), was classified as nearly complete remission [18,19]. All patients after hemithyroidectomy had no evidence of disease.…”

“…Furthermore, pregnancy in young female patients also potently influences bone status. Worldwide experience with female patients treated for DTC in young age and who were then receiving long-term TSHsuppressive therapy is very limited to date [9,11,18].…”