Twenty-Eight-Day Oral Toxicity, Genotoxicity, and Gender-Related Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats

Kim, Yong Soon; Kim, Jin Sik; Cho, Hyun Sun; Rha, Dae Sik; Kim, Jae Min; Park, Jung Duck; Choi, Byung Sun; Lim, Ruth; Chang, Hee Kyung; Chung, Yong Hyun; Kwon, Il Hoon; Jeong, Jayoung; Han, Beom Seok; Yu, Il Je

doi:10.1080/08958370701874663

Cited by 783 publications

(549 citation statements)

References 31 publications

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“…188,225 After 28 days of oral exposure of Sprague-Dawley rats to silver nanoparticles, the particles were found to accumulate in various organs. 171 Polystyrene nanoparticles were also taken up through gastrointestinal mucosa after gavage feeding, and their uptake efficiency was sizedependent. 24 These findings demonstrate the potential for nanoparticle-based oral drug delivery.…”

Section: Digestive Nanotoxicitymentioning

confidence: 99%

“…Twentyeight days after the oral administration of silver nanoparticles to Sprague-Dawley rats, the animals showed no toxic effects in bone marrow, as indicated by a constant ratio of polychromatic erythrocytes/(polychromatic erythrocytes + normochromatic erythrocytes). 171 Nanoparticles that affect adversely the hematopoietic system. Notwithstanding the above findings, some nanoparticles cause genotoxicity in bone marrow cells.…”

Section: Hematopoietic Toxicitymentioning

confidence: 99%

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Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Section: Digestive Nanotoxicitymentioning

confidence: 99%

Section: Hematopoietic Toxicitymentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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“…Regarding particle size, a group study reported that smaller sized nanoparticles were more genotoxic compared to their bulk counterparts [21]. Surface coatings of positively charged nanoparticles have also been found to enhance genotoxicity [22].…”

Section: Genotoxicitymentioning

confidence: 99%

Nanomaterials and Cell Interactions: A Review

Jackson¹,

Patani²,

Israel³

2017

JBNB

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Nanotoxicology, a branch of bionanoscience focuses on the study of the hazardous interactions between nanomaterials and the ecosystem and ascertaining its consequent implications. Nanomaterial-cell interactions are dependent on numerous factors such as size, shape, type and surface coatings/charge of nanomaterials. These factors in association with cell membrane factors such as charge and formation of the protein corona influence the uptake and internalization of these particles leading to their potential toxicity. Understanding the different routes of exposure, their transport, behaviour and eventual fate is also of importance. Toxicities that occur to the living systems are consequences of various causes/dysfunctions such as ROS production, loss of membrane integrity, releases of toxic metal ions that bind with specific cell receptors and undergo certain conformations that inhibit normal cell function resulting in cytotoxicity, genotoxicity and possible cell necrosis. This paper attempts to review the available research pertaining to nanomaterial-cell interactions and their potential toxicity.

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“…The enzyme is associated with bone formation and it is present in the bone ossification centre before hypertrophic chondrocytes become present. Furthermore, the content of silver in testes, kidneys, liver, brain, lungs and stomach increased with increasing levels of nano-Ag (Kim et al, 2008), suggesting that this could also be the case for bones. Nevertheless, no data is available regarding the nano-Ag content in bones, either during prenatal or postnatal development.…”

Section: Introductionmentioning

confidence: 99%

“…In rat studies, animals exposed to different doses of nano-Ag did not alter body and organ weights, blood biochemistry, haematological characteristics and did not cause bone marrow cytotoxicity. Elevated levels of alkaline phosphatase were observed, however (Kim et al, 2008). The enzyme is associated with bone formation and it is present in the bone ossification centre before hypertrophic chondrocytes become present.…”

Section: Introductionmentioning

confidence: 99%

Can silver nanoparticles affect the mineral content, structure and mechanical properties of chicken embryo bones?

Sikorska¹,

Szmidt²,

Sawosz³

et al. 2010

J. Anim. Feed Sci.

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Biomedical application of silver nanoparticles has recently gained much attention. In this study, we investigated whether hydrocolloids of silver nanoparticles (nano-Ag) are deposited in chicken bones during embryogenesis and to what extent they can affect biochemical characteristics, mineral content, structure, and mechanical properties of bones. Hydrocolloids (0.3 ml), containing 50 ppm of nano-Ag, were injected in ovo prior to incubation of eggs. After 20 days of incubation, blood and thigh bones were isolated and analysed. Nano-Ag was deposited in embryo thigh bones, but did not affect the structure or mechanical properties of the bone. There was no effect of nano-Ag on the selected biochemical indices, but there was a tendency towards increasing mineral content, indicating that nanoparticles may influence bone mineralization. Considering that nano-Ag is absorbed by the embryo skeleton without affecting bone properties, these particles might be a good candidate for carriers of micronutrients or drugs into bones.

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Twenty-Eight-Day Oral Toxicity, Genotoxicity, and Gender-Related Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats

Cited by 783 publications

References 31 publications

Perturbation of physiological systems by nanoparticles

Perturbation of physiological systems by nanoparticles

Nanomaterials and Cell Interactions: A Review

Can silver nanoparticles affect the mineral content, structure and mechanical properties of chicken embryo bones?

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