Twelve years' observation of multiple familial trichoepithelioma with squamous carcinoma

Abstract

Long-standing trichoepithelioma lesion on scalp with 12 years follow-up. The patient was observed for 12 years, and the carcinoma recurred 3 times during 8 years after surgical excision and radiation therapy. Malignant transformation may occur in multiple familial trichoepitheliomas; Moderate radiation therapy should be given for malignant transformation patients with lower radiation dose and shorter time. Removing the trichoepithelioma as soon as possible if the tumor suddenly or continuously increased is recommended.

Genetic Testing in CYLD Cutaneous Syndrome: An Update

“…In addition to the adnexal carcinomas above, cutaneous squamous cell carcinoma (cSCC) arising in patients with CCS has been described in isolated reports 30,31 as well as follicular cSCC. 32 Trichoblastic carcinoma has been reported to arise from preexisting trichoblastoma in CCS, 33 which can metastasise.…”