Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001

Bernstein, David I.; Wanner, Mark; Borish, Larry; Liss, Gary M.; th, the Immunotherapy Committee of

doi:10.1016/j.jaci.2004.02.006

Cited by 432 publications

(317 citation statements)

References 28 publications

(35 reference statements)

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“…Furthermore, we could not find any published reports identifying any life-threatening or fatal reactions when patients taking beta-blockers were skin prick tested. In contrast, there are 88 reports from the American Academy of Allergy and Immunology over this time of allergen immunotherapy fatalities, with 3 of these patients taking beta-blockers [33][34][35]. Thus, while there may be an increased risk of anaphylaxis in patients on beta-blockers undergoing immunotherapy, the degree of risk is likely smaller in patients undergoing allergy skin testing.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that fatalities from skin testing regardless of beta-blocker use are extremely rare. Through a national questionnaire study with members of the American Academy of Allergy and Immunology, seven fatalities are known: two occurring in 1964, four between 1980-1983, and one in a more recent report surveying the period between 1990-2001 [30][31][32]. None of these patients were known to be using beta-blockers.…”

Section: Discussionmentioning

confidence: 99%

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Skin Prick Testing In Patients Using Beta Blockers: A Retrospective Analysis

Fung¹,

Kim²

2009

Journal of Allergy and Clinical Immunology

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Rationale: The use of beta-blockers is a relative contraindication in allergen skin testing yet there is a paucity of literature on adverse events in this circumstance. We examined a population of skin tested patients on betablockers to look for any adverse effects. Methods: Charts from 2004-2008 in a single allergy clinic were reviewed for any patients taking a beta-blocker when skin tested. Data was examined for skin test reactivity, type of skin test, concomitant asthma diagnosis, allergens tested, and adverse events. Results: One hundred and ninety-one patients were taking beta-blockers when skin testing occurred. Seventy-two patients had positive skin tests. No tests resulted in an adverse event.Conclusions: This data demonstrates the relative safety of administrating of skin prick tests to patients on betablocker treatment. Larger prospective studies are needed to substantiate the findings of this study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Skin Prick Testing In Patients Using Beta Blockers: A Retrospective Analysis

Fung¹,

Kim²

2009

Journal of Allergy and Clinical Immunology

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“…Anaphylaxis can be elicited for every concentration of the antigen (also minimal, sometimes it happens during skin test for drugs, etc.) (Bernstein et al, 2004;Blanton & Sutphin, 1949;Eleuterio Gonzàlez et al, 1997;Harris & Sure, 1950;Liccardi et al, 2006;Lockey et al, 1987;Riezzo, 2010;Weber-Mani & Pichler, 2008). The typical anaphylaxis consists of sudden weakness, itching and urticaria, chest oppression, respiratory distress (wheezing) followed by cardio-circulatory collapse.…”

Section: Pathogenesismentioning

confidence: 99%

Forensic Investigation in Anaphylactic Deaths

Trani¹,

Bonetti²,

Gualandri³

et al. 2011

Forensic Medicine - From Old Problems to New Challenges

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“…SCIT is effective and safe, when properly prescribed and administered, but a certain level of risk of severe side effects still remains [1]. The problem of the risk/benefit ratio prompted, mainly during the 1980's, the search for safer routes of administration, among which, the sublingual one (SLIT), first described in 1986, achieved both scientific and clinical importance.…”

Section: Introductionmentioning

confidence: 99%