Twelve-Year Analysis of Severe Cases of Drug Reaction With Eosinophilia and Systemic Symptoms

Eshki, Majed; Allanore, L.; Musette, Philippe; Milpied, B.; Grange, A.; Guillaume, J; Chosidow, Olivier; Guillot, Isabelle; Paradis, Valérie; Joly, P.; Crickx, B; Ranger-Rogez, Sylvie; Descamps, Véronique

doi:10.1001/archderm.145.1.67

Cited by 272 publications

(259 citation statements)

References 26 publications

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“…Reactivation of human herpesvirus (HHV), mainly HHV-6, and less frequently cytomegalovirus, has been described during the course of DIHS ⁄ DRESS. [5][6][7][8] These viral…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenetics of cutaneous adverse drug reactions

Aihara

2011

The Journal of Dermatology

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Drug-induced hypersensitivity reactions are of major medical concern because they are associated with high morbidity and high mortality. In addition, individual patients' reactions are impossible to predict in each patient. In the field of severe cutaneous adverse drug reactions (cutaneous ADR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug-induced hypersensitivity syndrome (DHIS) or drug rash with eosinophilia and systemic symptoms (DRESS), major advances have recently been gained through studies of an association between HLA alleles and drug hypersensitivity induced by specific drugs. The results of these pharmacogenomic studies allow prediction of the risk of adverse reactions in patients treated with certain drugs, including carbamazepine and other aromatic antiepileptic drugs, allopurinol and abacavir. However, different ethnic populations show variations in the genetic associations. A strong association between carbamazepine-induced SJS ⁄ TEN and HLA-B*1502 has been found in Southeast Asian patients but not in Caucasian and Japanese patients. Moderate associations between aromatic amine anticonvulsants and other HLA alleles have been proposed in Japanese patients. In contrast, HLA-B*5801 was found to be associated with allopurinol-induced cutaneous ADR, including SJS ⁄ TEN and DIHS ⁄ DRESS, in Caucasian and Asian patients, including the Japanese. These differences may, at least in part, be due to the differences in allele frequency in different ethnic populations. This article reviews the progress in pharmacogenomics, associated mainly with carbamazepine and allopurinol in different ethnic populations. Pharmacogenetic screening based on associations between adverse reactions and specific HLA alleles helps to avoid serious conditions associated with drug hypersensitivity.

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“…Reactivation of human herpesvirus (HHV), mainly HHV-6, and less frequently cytomegalovirus, has been described during the course of DIHS ⁄ DRESS. [5][6][7][8] These viral…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenetics of cutaneous adverse drug reactions

Aihara

2011

The Journal of Dermatology

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“…Both patients were discharged from the hospital after longer hospital stays than planned. According to earlier studies, early withdrawal of the offending medication improves prognosis and supports the use of steroids in management of DRESS syndrome [24,25].…”

Section: Discussionmentioning

confidence: 83%

Lamotrigine-Related Severe Cutaneous Adverse Reaction in Patient with Epilepsy

Kw¹

2015

J Neurol Disord

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“…Diagnostic criteria include widespread rash, fever, and laboratory abnormalities (eosinophilia >1,500/mm 3 or atypical lymphocytes) (1)(2)(3)(4)(5)(6)(7) . Systemic involvement affecting the liver (50%), kidneys (10%), lungs (10%), heart, pancreas, and others may also be observed with laboratory testing revealing specific organ damage (2)(3)(4) .…”

Section: Discussionmentioning

confidence: 99%

DRESS syndrome in ophthalmic patients

Sousa¹,

Nascimento²,

Belfort³

2016

Arquivos Brasileiros De Oftalmologia

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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal adverse drug reaction associated with skin rash, fever, eosinophilia, and multiple organ injury. A number of pharmacological agents are known to cause DRESS syndrome such as allopurinol, anticonvulsants, vancomycin, trimethoprime-sulfamethoxazole, and pyrimethamine-sulfadiazine. Here, we describe two patients who developed DRESS syndrome during ocular treatment. The first case was being treated for late postoperative endophthalmitis with topical antibiotics, intravenous cephalothin, meropenem, and intravitreal injection of vancomycin and ceftazidime before symptoms developed. We were unable to identify the causal drug owing to the large number of medications concurrently administered. The second case presented with DRESS syndrome symptoms during ocular toxoplasmosis treatment. In this case, a clearer association with pyrimethamine-sulfadiazine was observed. As a result of the regular prescription of pharmacological agents associated with DRESS syndrome, ophthalmologists should be aware of the potentially serious complications of DRESS syndrome.

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Twelve-Year Analysis of Severe Cases of Drug Reaction With Eosinophilia and Systemic Symptoms

Cited by 272 publications

References 26 publications

Pharmacogenetics of cutaneous adverse drug reactions

Pharmacogenetics of cutaneous adverse drug reactions

Lamotrigine-Related Severe Cutaneous Adverse Reaction in Patient with Epilepsy

DRESS syndrome in ophthalmic patients

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