2009
DOI: 10.1001/archderm.145.1.67
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Twelve-Year Analysis of Severe Cases of Drug Reaction With Eosinophilia and Systemic Symptoms

Abstract: Background: Factors implicated in the severity of drug reaction with eosinophilia and systemic symptoms (DRESS) have not been identified. We retrospectively describe and analyze severe cases of DRESS defined by history of intensive care unit admission and death due to DRESS.Observations: Of 15 patients retrospectively recruited in France, 14 were admitted to the intensive care unit and 3 died. The culprit drugs were already known to cause or trigger DRESS: allopurinol, minocycline hydrochloride, anticonvulsant… Show more

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Cited by 263 publications
(232 citation statements)
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“…Reactivation of human herpesvirus (HHV), mainly HHV-6, and less frequently cytomegalovirus, has been described during the course of DIHS ⁄ DRESS. [5][6][7][8] These viral…”
Section: Introductionmentioning
confidence: 99%
“…Reactivation of human herpesvirus (HHV), mainly HHV-6, and less frequently cytomegalovirus, has been described during the course of DIHS ⁄ DRESS. [5][6][7][8] These viral…”
Section: Introductionmentioning
confidence: 99%
“…Both patients were discharged from the hospital after longer hospital stays than planned. According to earlier studies, early withdrawal of the offending medication improves prognosis and supports the use of steroids in management of DRESS syndrome [24,25].…”
Section: Discussionmentioning
confidence: 83%
“…Diagnostic criteria include widespread rash, fever, and laboratory abnormalities (eosinophilia >1,500/mm 3 or atypical lymphocytes) (1)(2)(3)(4)(5)(6)(7) . Systemic involvement affecting the liver (50%), kidneys (10%), lungs (10%), heart, pancreas, and others may also be observed with laboratory testing revealing specific organ damage (2)(3)(4) .…”
Section: Discussionmentioning
confidence: 99%