Twelve-Month Neurofunctional Assessment and Cognitive Performance at 36 Months of Age in Extremely Low Birth Weight Infants

Giannì, Maria Lorella; Picciolini, Odoardo; Vegni, C; Gardon, Laura; Fumagalli, Monica; Mosca, Fabio

doi:10.1542/peds.2006-3364

Cited by 29 publications

(19 citation statements)

References 32 publications

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“…Nicotine is usually presented to the fetus through maternal smoking or environmental exposure to second-hand smoke. Research has provided unequivocal evidence that active smoking and passive exposure to second-hand smoke can be teratogenic (for review, see 82), can lead to decreased birth weight and can increase the risks of preterm birth and SIDS (Table 1), all of which are high risk factors for behavioral impairment 69, 83-85. Numerous studies support a robust relationship between developmental tobacco smoke exposure and attention deficit disorders, hyperactivity, antisocial behavior and learning disabilities 86-94.…”

Section: Effects Of Legal Drugs Of Abusementioning

confidence: 99%

Prenatal exposure to drugs: effects on brain development and implications for policy and education

2009

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The effects of prenatal exposure to drugs on brain development are complex and are modulated by the timing, dose, and route of drug exposure. It is difficult to assess these effects in clinical cohorts, which are beset with multiple exposures and difficulties in documenting use patterns. This can lead to misinterpretation of research findings by the general public, the media and policy makers, who may mistakenly assume that the legal or illegal status of a drug correlates with its biological impact on fetal brain development and long-term clinical outcomes. It is important to close the gap between what science tells us about the impact of prenatal drug exposure on the fetus and the mother, and what we do programmatically with regard to at-risk populations.

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Section: Effects Of Legal Drugs Of Abusementioning

confidence: 99%

Prenatal exposure to drugs: effects on brain development and implications for policy and education

2009

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“…Neurofunctional assessment at 12 months of extremely low birth weight infants born in 1996-2001, along with magnetic resonance imaging status and chronic lung disease, predicted cognitive function at 36 months (Gianni et al 2007). Children born <26 weeks in 1995 had a mean mental developmental index of 84 and a psychomotor developmental index of 87 at 30 months; 49% had cognitive or neurologic disability and 23% were severely disabled .…”

Section: A Focus On Longitudinal Studymentioning

confidence: 99%

Extremely Preterm Birth Outcome: A Review of Four Decades of Cognitive Research

Baron

Rey‐Casserly

2010

Neuropsychol Rev

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Premature birth incidence and survival rates are increasing steadily due to advances in obstetric and neonatal intensive care. Those born at the limits of viability are highly at-risk of adverse neurocognitive function over their lifespan, leading to current controversy regarding aggressive resuscitation efforts for these extremely preterm children. However, data from earlier generation cohorts who were born in substantially different eras of neonatal intensive care cannot be relied on to predict outcome of today's newborn. Our review by the crucial variable of birth cohort year shows a changing developmental trajectory in which today's extremely preterm survivor is likely to have fewer severe medical complications, better neurological outcomes, and fewer adverse cognitive late effects. Such data further underscore the importance of concurrently considering medical, familial, socioenvironmental, and neurobiological factors in combination with individual neonatal intensive care center protocols when studying outcomes of the preterm child. This complex, interrelated range of factors directly affects the immature, rapidly developing premature brain. However, ongoing surveillance to detect subsequent delay or impairment and to apply interventional strategies early in the developmental course holds promise for further enhancement of functional outcome.

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“…Exclusion criteria were the multiple birth, the presence of genetic abnormalities, severe neurofunctional impairment (defined as Neurofunctional Assessment > 2, Picciolini et al, 2006; Gianní et al, 2007), and/or neurosensory disabilities (blindness, deafness). We decided such exclusion criteria because having fine motor control and sensory orientation was a prerequisite for undergoing the cognitive assessment we administered.…”

Section: Methodsmentioning

confidence: 99%

Seven Years Cognitive Functioning and Early Assessment in Extremely Low Birth Weight Children

et al. 2017

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Infants born preterm are at high risk for the onset of cognitive dysfunctions at school age. The aim of this study was to investigate the association between early neurodevelopmental assessment and the risk of adverse cognitive outcome in extremely low birth weight children. We enrolled all newborns (January 2002 – April 2007) consecutively admitted to our Institution, with a birthweight < 1000 g. Exclusion criteria were genetic abnormalities, severe neurofunctional impairment, and/or neurosensory disabilities. Ninety-nine children were assessed at 1 year of corrected age using the Griffiths Mental Development Scales Revised. The same children were re-assessed at school age through the Wechsler Intelligence Scale for Children. Children with impaired Griffiths General Quotient (i.e., <1 SD) at 1 year of corrected age showed a significantly lower Full Scale Intelligence Quotient at 7 years of chronological age when compared to children who scored in the normal range at 1 year (p < 0.01). Considering the Griffiths Sub-quotients separately, a poor score in the Performance or in the Personal-Social Sub-quotients at 1 year was associated with significantly worse cognitive outcomes both in the Verbal and in the Performance Intelligence Quotients at 7 years (p < 0.01 and p < 0.05, respectively). A score <1 SD in the Locomotor or in the Eye and Hand Coordination Sub-quotients were specifically associated with poorer Performance or Verbal Intelligence Quotients, respectively (p < 0.05). Our findings suggest that a poor score on the Griffiths Scales at 1 year is associated with a higher risk of cognitive impairment at school age. Larger confirmation studies are needed.

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Twelve-Month Neurofunctional Assessment and Cognitive Performance at 36 Months of Age in Extremely Low Birth Weight Infants

Abstract: The 12-month neurofunctional evaluation may be an additional useful clinical tool in predicting later cognitive outcome in extremely low birth weight children.

Cited by 29 publications

References 32 publications

Prenatal exposure to drugs: effects on brain development and implications for policy and education

Prenatal exposure to drugs: effects on brain development and implications for policy and education

Extremely Preterm Birth Outcome: A Review of Four Decades of Cognitive Research

Seven Years Cognitive Functioning and Early Assessment in Extremely Low Birth Weight Children

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