Twelve-Dose Drug Regimen Now Also an Option for Preventing Tuberculosis in Children and Adolescents

Marais, Ben J.

doi:10.1001/jamapediatrics.2014.3157

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…However, the small number of children under 5 years of age and of children infected with HIV limits the generalization of the study results in these important risk groups. 55 , 56 …”

Section: Latent Tuberculosis Infection (Ltbi)mentioning

confidence: 99%

Tuberculosis treatment

et al. 2017

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Tuberculosis treatment remains a challenge due to the need to consider, when approaching it, the context of individual and collective health. In addition, social and economic issues have been shown to be variables that need to be considered when it comes to treatment effectiveness. We conducted a critical review of the national and international literature on the treatment of tuberculosis in recent years with the aims of presenting health care workers with recommendations based on the situation in Brazil and better informing decision-making regarding tuberculosis patients so as to minimize morbidity and interrupt disease transmission.

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“…However, the small number of children under 5 years of age and of children infected with HIV limits the generalization of the study results in these important risk groups. 55 , 56 …”

Section: Latent Tuberculosis Infection (Ltbi)mentioning

confidence: 99%

Tuberculosis treatment

et al. 2017

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“…35,36 Feasibility and adherence would be greatly improved by shortcourse therapy options, such as 3 months of daily isoniazid and rifampicin or 12 weekly-doses of isoniazid and rifapentine. 37 The availability of a water dissolvable fixed-dose combination tablet that contains 50 mg isoniazid and 75 mg rifampicin offers excellent opportunities to revive preventive therapy programmes and improve adherence, 38 especially in settings with low rates of HIV co-infection where potential drug-drug interactions caused by rifampicin are not of concern. It is hoped that child-friendly isoniazid and rifapentine combination tablets will also be developed, since this will greatly simplify preventive therapy administration and supervision.…”

Section: Poor Adherence With Prolonged Isoniazid Preventive Therapymentioning

confidence: 99%

Improving access to tuberculosis preventive therapy and treatment for children

Marais

2017

International Journal of Infectious Diseases

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Children suffer a huge burden of disease in tuberculosis (TB) endemic countries. This disease burden was largely invisible when TB control programmes focused exclusively on adults with sputum smear-positive disease. High-level advocacy and better data have improved visibility, but the establishment of functional paediatric TB programmes remains challenging. The key issues that limit children's access to TB preventive therapy and treatment in endemic areas are briefly discussed. Barriers to preventive therapy include (1) the perceived inability to rule out active disease, (2) fear of creating drug resistance, (3) non-implementation of existing guidelines in the absence of adequate monitoring, and (4) poor adherence with long preventive therapy courses. Barriers to TB treatment include (1) perceived diagnostic difficulties, (2) non-availability of chest radiography, (3) young children presenting to unprepared maternal and child health (MCH) services, and (4) the absence of child-friendly formulations. With drug-resistant disease there is currently no guidance on the use of preventive therapy and treatment is usually restricted to cases with bacteriologically confirmed disease, which excludes most young children from care, even if their likely source case has documented drug-resistant TB.

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Recent Innovations in Diagnosis and Treatment of Pediatric Tuberculosis

Gaensbauer

Broadhurst

2019

Curr Infect Dis Rep

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Twelve-Dose Drug Regimen Now Also an Option for Preventing Tuberculosis in Children and Adolescents

Cited by 6 publications

References 10 publications

Tuberculosis treatment

Tuberculosis treatment

Improving access to tuberculosis preventive therapy and treatment for children

Recent Innovations in Diagnosis and Treatment of Pediatric Tuberculosis

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