Tween 20-cinnamic acid conjugate as a UV-absorbing emulsifier

Wang, Minhui; Kim, Jin‐Chul

doi:10.1016/j.colsurfa.2014.03.076

Cited by 6 publications

(6 citation statements)

References 26 publications

(22 reference statements)

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“…Cinnamic acid (CA) was identified as a UV protecting molecule because it absorbs a broad range of UV light. CA was covalently attached to a nonionic PS to obtain a UV absorbing emulsifier [108]. After covalent conjugation with a PS, the nature of molar extinction coefficient of CA residue did not change.…”

Section: Ps-conjugated Drugs or Drug Carriersmentioning

confidence: 99%

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Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

et al. 2021

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Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applications of PS-based drug formulations. Additionally, recent advances in brain-targeted drug delivery using PS-based drug formulations have been highlighted. This review will help researchers understand the potential of PSs as effective drug formulation agents.

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Section: Ps-conjugated Drugs or Drug Carriersmentioning

confidence: 99%

“…This result indicates that CA could absorb the UV light after conjugation to the PS. In vitro cytotoxicity of various surfactant-CA conjugates were evaluated, and the cell viability was higher than 80% at the concentration of 0.2% for all the conjugates tested [108,109].…”

Section: Ps-conjugated Drugs or Drug Carriersmentioning

confidence: 99%

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

et al. 2021

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“…In addition, the air=water interfacial activity of the conjugate was higher than that of unmodified Tween 20, and the emulsion stabilized with Tween 20-CA conjugate was much more stable than the emulsion with unmodified Tween 20. [1] However, the number of CAs which could be covalently attached to one molecule of Tween 20 was limited, around 1, despite Tween 20 having three ethylene oxide chains. The steric hindrance of covalently attached CA is thought to prevent further conjugation.…”

Section: Introductionmentioning

confidence: 99%

“…The steric hindrance of covalently attached CA is thought to prevent further conjugation. [1] In addition, Tween 20 is somewhat toxic and may cause skin irritation. [3] In order to circumvent the shortcomings described above, CA was conjugated to gelatin (Gel), and the Gel-CA conjugates were evaluated in terms of the UVabsorbing and the emulsifying capability.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, cinnamic acid (3-phenylprop-2-enoic acid, CA) was covalently attached to the ethylene oxide chains of Tween 20 (polyoxyethylene sorbitan monolaurate, polysorbate 20, a commercially available surfactant), and Tween 20-CA conjugate was proposed to be used as an UV-protecting emulsifier, which could act as not only an emulsifier but also a UV-protecting agent. [1] CA and its derivatives are contained in cosmetic preparations as a UV-protecting agent, due to their capability of absorbing a broad range of UV light, their high extinction coefficient, and their low toxicity to human body. [2] CA could be covalently attached to Tween 20 without the loss of its photochromic property.…”

Section: Introductionmentioning

confidence: 99%

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UV-Absorbing and Emulsifying Property of Cinnamic Acid-Conjugated Gelatin

Lee

Kim

2014

Journal of Dispersion Science and Technology

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Functional Colloidal Stabilization

Bijlard

Wald

Crespy

et al. 2016

Adv Materials Inter

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acids), and protective agents. The unifying concept and key property of colloidal stabilizers is to provide a significant repulsion between the individual dispersed particles, making the heterophase system kinetically stable, which is typically accomplished via electrostatic or steric stabilization.Functional colloid stabilization provides additional features in addition to simple repulsion via physisorbed molecules. In fact, it is surprising that the majority of artificial heterophase systems have overlooked the simple and efficient possibility of spatially resolved chemical modification. The utilization of surface-active functional stabilizers is a fast and flexible method to obtain colloidal particles with strongly improved interaction properties. This functionalization has proved extremely material-and time-efficient. Due to the self-assembling ability of the stabilizers, the functional groups allow for an exact positioning of chemical and physical interaction sites directly in the surface region of the colloidal particle.The purpose of this review is to highlight functional colloidal stabilization as defined above. Our main focus concentrates on reactive systems, especially heterophase polymerization in oil-in-water (o/w) and water-in-oil (w/o) emulsions; a waterin-oil emulsion is regarded as an inverse emulsion. We differentiate between various types of surfactants which can either adsorb or react to the dispersed material with one segment, while the second part of the amphiphile stabilizes the dispersion. The stability of emulsions can be obtained by either low or high mole cular weight surfactants. Additionally, we distinguish between surfactants from so-called protective colloids of higher mole cular weight without significant self-aggregation properties. Throughout this review, the literature on functional colloidal stabilizers was revised and classified according to molecular weight, preparation technique, chemical structure, and stimuli-responsive behavior. Certain aspects such as inorganic/organic hybrids, or bioconjugates with sequence-defined structures such as peptides and nucleotides, are not in the scope of the present review and will only be briefly described when relevant.The review is structured as follows: we start with a brief summary of conventional low molecular weight (Section 2.1) and polymeric surfactants (Section 2.2) which typically lack of additional function besides the colloid stabilization. Only some of these also industrially used surfactants carry, for example, olefins or hydroxyl-groups embedded in their chemical structure, but do not have additional handles to the colloids. After this Surfactants can stabilize colloids in dispersion; however, also additional chemical or physical functions can be added by the surfactant chemistry to the colloid. This review covers functional colloid stabilization whereby supplementary features in addition to simple repulsion via physisorbed mole cules are described. The utilization of surface-active functional stabilizers as a fast and flexibl...

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Tween 20-cinnamic acid conjugate as a UV-absorbing emulsifier

Cited by 6 publications

References 26 publications

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

UV-Absorbing and Emulsifying Property of Cinnamic Acid-Conjugated Gelatin

Functional Colloidal Stabilization

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