Turnover of free fatty acids during recovery from exercise

Hagenfeldt, Lars; Wahren, John

doi:10.1152/jappl.1975.39.2.247

Cited by 28 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A progressive rise of serum FFA levels dur ing exercise and peaking of FFA levels in the postexercise periods have previously been well documented (1,10). These effects were con firmed in the present study and used to investi gate the influence of FFA on drug binding.…”

Section: Discussionsupporting

confidence: 63%

Plasma Levels and Protein Binding of Phenytoin during Exercise in Man: the Effect of Elevated Free Fatty Acids

Borgå¹,

Juhlin-Dannfeldt²,

Dahlqvist³

1978

Pharmacology

View full text Add to dashboard Cite

Five healthy subjects performed submaximal physical exercise approximately 20 h after a single oral dose of phenytoin (5 mg/kg of the sodium salt). The plasma levels of free fatty acids (FFA) increased 2- to 3-fold in the post-exercise period. In spite of this, the degree of plasma binding of phenytoin and its total concentration in plasma were unaffected. Thus FFA at the levels reached (1.5–2.9 mEq/1), did not displace phenytoin from its binding sites on albumin. Furthermore, during the FFA peak the plasma protein binding of warfarin, as measured in vitro, did not decrease as compared to the pre-exercise period. These findings contrast to previous observations in rats and dogs, where FFA caused a considerable displacement of warfarin and phenytoin at relatively low FFA/albumin molar ratios.

show abstract

Section: Discussionsupporting

confidence: 63%

Plasma Levels and Protein Binding of Phenytoin during Exercise in Man: the Effect of Elevated Free Fatty Acids

Borgå¹,

Juhlin-Dannfeldt²,

Dahlqvist³

1978

Pharmacology

View full text Add to dashboard Cite

show abstract

“…Thus, muscle uptake of FFA at rest and during exercise has been demonstrated to depend not only on arterial concentration, but also on blood flow to the exercising muscles (10,21,22). Furtheimore, the increase in the fractional turnover of FFA during exercise is related to the increased cardiac output (21,23). A hyperkinetic circulation with an increased heart rate and cardiac output are typical findings in hyperthyroidism (24).…”

Section: Discussionmentioning

confidence: 99%

Turnover and splanchnic metabolism of free fatty acids in hyperthyroid patients.

Hagenfeldt¹,

Wennlung²,

Felig³

et al. 1981

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The arterial concentration and turnover rate and the splanchnic exchange of FFA were examined after an overnight fast in a group of 11 female patients with clinical and laboratory evidence ofhyperthyroidism.[14C]oleic acid was infused intravenously and the hepatic venous catheter technique was used.As compared with healthy control individuals, the arterial concentrations of FFA and oleic acid were elevated by 30-40% in the hyperthyroid group. Both the turnover rate and the fractional turnover of oleic acid were significantly increased. The turnover rate correlated directly with arterial concentration of oleic acid in both the control and the patient group but the slope was steeper in the patients. The splanchnic uptake of oleic acid was three times higher than in the control group. The augmented uptake was a consequence of elevated arterial concentrations and increased hepatic plasma flow, whereas fractional splanchnic uptake remained unchanged. Ketone body production was four-to fivefold greater in the patients and could be largely accounted for by increased splanchnic FFA uptake. In six patients studied after treatment resulting in a return to normal thyroid function, a significant reduction was observed in arterial FFA, estimated hepatic blood flow, oleic acid turnover, and ketone body production.It is concluded that hyperthyroidism is characterized by increased turnover and splanchnic uptake of FFA and augmented ketogenesis. These findings can be explained on the basis of elevated arterial FFA concentrations and increased blood flow, particularly to the splanchnic bed.

show abstract

“…However, FFA becomes the main fuel during moderate, prolonged aerobic exercise and after long-term fasting, consequently plasma FFA levels rise appreciably (Costill et al 1977;Hagenfeldt and Wahren 1975;Jones et al 1980). On the other hand, at the onset of exercise, FFA uptake is more rapid than FFA release and plasma levels decrease until a new balance is established, and uptake matches release (Arner 1996).…”

Section: Ar and Hormonesmentioning

confidence: 99%

Active recovery and post-exercise white blood cell count, free fatty acids, and hormones in endurance athletes

et al. 2001

View full text Add to dashboard Cite

Strenuous endurance exercise in fasted subjects is accompanied by increased plasma levels of catecholamines, leucocytosis, low insulin, and elevated plasma free fatty acids (FFA). Immediately after such exercise, plasma FFA may rise to high and potentially harmful levels, whereas the white blood cell count (WBCC) rapidly decreases towards or below baseline values. The present work investigated how active recovery (AR) for 15 min at 50% of maximal oxygen consumption (VO2max), after 60 min of uphill running at 83% of VO2max, influenced plasma FFA, lymphocyte, neutrophil, granulocyte, and monocyte count, as well as adrenaline, noradrenaline, insulin and cortisol concentrations until 120 min post-exercise. Thirteen endurance athletes participated in the study [24.2 (3.7) years, 1.82 (0.06) m, 76.7 (7.9) kg and VO2max 69.2 (6.8) ml min-1 kg-1]. In a randomized order, the subjects completed two sets of strenuous workouts, followed by either AR or complete rest in the supine position (RR). Compared with RR, AR strongly counteracted the rapid increase in plasma FFA 5 min post-exercise. The decreases in neutrophil and monocyte counts post-exercise were nullified by AR, and the cell count stayed above resting values throughout the observation period. AR also counteracted the rapid return of hormone concentration towards baseline levels. It would appear that active recovery at low intensity after strenuous exercise can maintain sufficient adrenergic activation to counteract the post-exercise drop in WBCC. However, in spite of keeping the catecholamine concentration high and insulin levels low, AR can also maintain a low plasma FFA concentration, probably because of the continued use of FFA in muscle. It remains to be elucidated whether the observed high FFA and low WBCC values after RR have a negative effect on health. If so, AR could be a preventive measure.

show abstract

Turnover of free fatty acids during recovery from exercise

Cited by 28 publications

References 0 publications

Plasma Levels and Protein Binding of Phenytoin during Exercise in Man: the Effect of Elevated Free Fatty Acids

Plasma Levels and Protein Binding of Phenytoin during Exercise in Man: the Effect of Elevated Free Fatty Acids

Turnover and splanchnic metabolism of free fatty acids in hyperthyroid patients.

Active recovery and post-exercise white blood cell count, free fatty acids, and hormones in endurance athletes

Contact Info

Product

Resources

About