Turning solid into gel for high-efficient persistent luminescence-sensitized photodynamic therapy

Sun, Shao‐Kai; Wu, Jiumn-Yih; Wang, Haoyu; Zhou, Li; Zhang, Cai; Cheng, Ran; Kan, Di; Zhang, Xuejun; Chen, Yu

doi:10.1016/j.biomaterials.2019.119328

Cited by 44 publications

(25 citation statements)

References 69 publications

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“…[ 214 ] These hydrogels fixated in the desired region, persistently releasing light and leading to continuous ROS production and significant tumor size decreases. [ 214 ]…”

Section: Hydrogels In Photomedicinementioning

confidence: 99%

Engineering Hydrogel‐Based Biomedical Photonics: Design, Fabrication, and Applications

et al. 2021

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Light guiding and manipulation in photonics have become ubiquitous in events ranging from everyday communications to complex robotics and nanomedicine. The speed and sensitivity of light–matter interactions offer unprecedented advantages in biomedical optics, data transmission, photomedicine, and detection of multi‐scale phenomena. Recently, hydrogels have emerged as a promising candidate for interfacing photonics and bioengineering by combining their light‐guiding properties with live tissue compatibility in optical, chemical, physiological, and mechanical dimensions. Herein, the latest progress over hydrogel photonics and its applications in guidance and manipulation of light is reviewed. Physics of guiding light through hydrogels and living tissues, and existing technical challenges in translating these tools into biomedical settings are discussed. A comprehensive and thorough overview of materials, fabrication protocols, and design architectures used in hydrogel photonics is provided. Finally, recent examples of applying structures such as hydrogel optical fibers, living photonic constructs, and their use as light‐driven hydrogel robots, photomedicine tools, and organ‐on‐a‐chip models are described. By providing a critical and selective evaluation of the field's status, this work sets a foundation for the next generation of hydrogel photonic research.

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“…[ 214 ] These hydrogels fixated in the desired region, persistently releasing light and leading to continuous ROS production and significant tumor size decreases. [ 214 ]…”

Section: Hydrogels In Photomedicinementioning

confidence: 99%

Engineering Hydrogel‐Based Biomedical Photonics: Design, Fabrication, and Applications

et al. 2021

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“…However, most photosensitizers for PDT need continuous activation by UV or visible light for a long time, leading to the limitation of the penetration depth in tissues and the irradiation induced overheating and cell damages. PLNPs with long-lasting NIR emission can serve as a persistent light source for PDT activation without any need for continuous photonic excitation [ 128 – 130 ]. This promising feature can minimize the deleterious side effects of PDT and provide convenient clinical cancer treatment without continuous external irradiation [ 131 – 133 ].…”

Section: Plnps-based Imaging-guided Therapymentioning

confidence: 99%

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Ding

et al. 2020

Nano-Micro Lett.

135

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Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation. In the past decade, persistent luminescence nanoparticles (PLNPs) with intriguing optical properties have attracted a wide range of attention in various areas. Especially in recent years, the development and applications in biomedical fields have been widely explored. Owing to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission, many researches have focused on the manipulation of PLNPs in biosensing, cell tracking, bioimaging and cancer therapy. These achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple functions. In this review, we summarize the works on synthesis methods, bioapplications, biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing, imaging and imaging-guided therapy. We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications. Finally, the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications.

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“…As noted by Akkaya and co-workers, only a modest photocytotoxicity against HepG2 cells was observed due to the short PeL emission lifetime in biological media. Re-charging the PeL is a strategy to repopulate the excited states of the PeL-NP and restore the PeL [ 276 , 277 , 278 , 279 , 280 , 281 ]. Solubilizing in water and targeting the PeL-NPs into cancer cells adds another challenge for in vivo PDT.…”

Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

“…An additional challenge for application in biological systems is the extensive emission quenching caused by the solvent. Synthetic methodologies to achieve hydrogels, hollow silica interlayers or hollow cavities with controllable size aim to achieve long-lasting PeL and improve cell biocompatibility [ 278 , 279 , 280 , 281 ]. For example, tumor-injectable oleosol implants are obtained by dissolving the PeL-NPs in a mixture of poly(lactic- co -glycolic acid)/ N -methylpyrrolidone [ 279 ].…”

Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

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The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.

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Turning solid into gel for high-efficient persistent luminescence-sensitized photodynamic therapy

Cited by 44 publications

References 69 publications

Engineering Hydrogel‐Based Biomedical Photonics: Design, Fabrication, and Applications

Engineering Hydrogel‐Based Biomedical Photonics: Design, Fabrication, and Applications

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

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