Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population

Verheugt, Carianne L.; Uiterwaal, Cuno S.P.M.; Velde, Enno T. van der; Meijboom, Folkert J.; Pieper, Petronella G.; Veen, Gerrit; Stappers, Jan; Grobbee, Diederick E.; Mulder, Barbara J.M.

doi:10.1093/eurheartj/ehq485

Cited by 99 publications

(62 citation statements)

References 45 publications

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“…In adults with CHD, the overall incidence rate of IE has been reported as 11 per 10 000 person-years in the CONCOR database in the Netherlands. 21 The overall rate of IE in our study was ≈3 times lower than the published estimate in adults with CHD. The reduced frequency of IE in children versus adults with CHD parallels the trend in the general population, where the incidence of IE in adults ranges from 15 to 60 cases per million person-years, 22 whereas in children it is lower at 3.9 to 6.4 cases per million person-years.…”

Section: Cumulative Incidence Of Iecontrasting

confidence: 68%

Infective Endocarditis in Children With Congenital Heart Disease

et al. 2013

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We sought to address these questions in patients with CHD by determining the cumulative incidence and predictors for the development of IE in a large population-based cohort of affected children. Methods Data SourcesQuebec is Canada's second most populated province with nearly 8 million inhabitants.15 A unique healthcare number is assigned Background-The American Heart Association guidelines for prevention of infective endocarditis (IE) in 2007 reduced the groups of congenital heart disease (CHD) patients for whom antibiotic prophylaxis was indicated. The evidence base in CHD patients is limited. We sought to determine the risk of IE in children with CHD. Methods and Results-We performed a population-based analysis to determine the cumulative incidence and predictors of IE in children (0-18 years) with CHD by the use of the Quebec CHD Database from 1988 to 2010. In 47 518 children with CHD followed for 458 109 patient-years, 185 cases of IE were observed. Cumulative incidence of IE was estimated in the subset of 34 279 children with CHD followed since birth, in whom the risk of IE up to 18 years of age was 6.1/1000 children (95% confidence interval, 5.0-7.5). In a nested case-control analysis, the following CHD lesions were at highest risk of IE in comparison with atrial septal defects (adjusted rate ratio, 95% confidence interval): cyanotic CHD (6.44, 3.95-10.50), endocardial cushion defects (5.47, 2.89-10.36), and left-sided lesions (1.88, 1.01-3.49). Cardiac surgery within 6 months (5.34, 2.49-11.43) and an age of <3 years (3.53, 2.51-4.96; reference, ages 6-18) also conferred an elevated risk of IE. Conclusions-In a large population-based cohort of children with CHD, we documented the cumulative incidence of IE and associated factors. These findings help identify groups of patients who are at the highest risk of developing IE.

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Section: Cumulative Incidence Of Iecontrasting

confidence: 68%

Infective Endocarditis in Children With Congenital Heart Disease

et al. 2013

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“…IZW występuje rzadziej u dzieci (0,04% na rok) niż u dorosłych z CHD (0,1% na rok) [444,445]. Stwierdzany odsetek pacjentów z CHD w populacji chorych z IZW różni się znacznie (prawdopodobnie na skutek błędu wynikającego z doboru grupy) i wynosi 2-60% [446][447][448][449][450], ze zgodnie podawaną przez różne źródła niewielką przewagą mężczyzn [443,451,452].…”

Section: Infekcyjne Zapalenie Wsierdziaunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

144

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“…4 However, despite these major advancements, a significant proportion of this patient population will have to undergo cardiovascular surgery at some point in adulthood, either for first corrective surgery or for reoperations to treat residual defects or long-term complications. [5][6][7][8][9] Although there has been rapid growth recently in interventional cardiology techniques to treat adults with congenital heart disease, 10 surgery remains an important treatment option, with Ϸ1 of 5 hospital admissions of adults with congenital heart disease being for cardiovascular surgery. [11][12][13] …”

mentioning

confidence: 99%

Surgery in Adults With Congenital Heart Disease

et al. 2011

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Background-A significant proportion of patients with congenital heart disease require surgery in adulthood. We aimed to give an overview of the prevalence, distribution, and outcome of cardiovascular surgery for congenital heart disease. We specifically questioned whether the effects of surgical treatment on subsequent long-term survival depend on sex. Methods and Results-From the Dutch Congenital Corvitia (CONCOR) registry for adults with congenital heart disease, we identified 10 300 patients; their median age was 33.1 years. Logistic and Cox regression models were used to assess the association of surgery in adulthood with sex and with long-term survival. In total, 2015 patients (20%) underwent surgery for congenital heart disease in adulthood during a median follow-up period of 15.1 years; in 812 patients (40%), it was a reoperation. Overall, both first operations and reoperations in adulthood were performed significantly more often in men compared with women (adjusted odds ratioϭ1.4 [95% confidence interval, 1.2-1.6] and 1.2 [95% confidence interval, 1.0 -1.4], respectively). Patients with their third and fourth or more surgery in adulthood had a 2-and 3-times-higher risk of death compared with patients never operated on (adjusted hazard ratioϭ1.9 [95% confidence interval, 1.0 -3.6] and 2.7 [95% confidence interval, 1.1-6.3], respectively). Men with a reoperation in adulthood had a 2-times-higher risk of death than women (adjusted hazard ratioϭ1.9; 95% confidence interval, 1.0 -3.5). Conclusions-Of predominantly young adults with congenital heart disease, one fifth required cardiovascular surgery during a 15-year period; in 40%, the surgery was a reoperation. Men with congenital heart disease have a higher chance of undergoing surgery in adulthood and have a consistently worse long-term survival after reoperations in adulthood compared with women. (Circulation. 2011;124:2195-2201.)

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Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population

Cited by 99 publications

References 45 publications

Infective Endocarditis in Children With Congenital Heart Disease

Infective Endocarditis in Children With Congenital Heart Disease

2015 ESC Guidelines for the management of infective endocarditis

Surgery in Adults With Congenital Heart Disease

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