Turner-Syndrom Mit Voll Ausgebildeten Sekundären Geschlechtsmerkmalen Und Fertilität

Abstract

Two women with normally developed secondary sex characteristics are reported. Both had spontaneous menstrual cycles, the first one during a period of 4 years, the second one started menstrual bleedings at the age of 17 and had menstrual cycles of regular intervals up to the present age of 39. She had given birth to a healthy boy at the age of 31. Both patients are chromatinnegative, of short stature and one has a unilateral webbed neck. Therefore they had to be classified as cases of Turner's syndrome. In cultures of bone marrow and skin fibroblasts the patient who has born a child was shown to have 45 chromosomes (2n + OX). The findings presented are in contrast to latest hypothesis of chromatinnegative Turner's syndrome according to which sex chromosomal anomaly XO leads to development of rudimentary ovaries.

Turner’s Syndrome – Review of the Literature with Reference to a Successful Pregnancy Outcome

“…At present, 19 pregnancies in 12 monosomy X pa tients have been reported [1,[5][6][7][8][9][10][11][12][13][14] (table 2). The stature was less than 142 cm in 10 cases.…”

“…A breakdown according to chromosome constitutions showed that 21 pregnancies were from 13 patients with 45,XO [1,[5][6][7][8][9][10][11][12][13][14] [37], Pregnancy in the first case terminated spontaneously in the 3rd month. In the second, one of the twins ended as stillbirth.…”

A boy with true hermaphroditism and sex chromosome mosaicism and a fertile woman with Turner mosaicism in a family with a translocation 8p:19p

“…1965). Fertility in a woman with 45,X Turner's syndrome was described for the first time by Bahner et al (1960). Since then, a further six cases have been reported (Schokeir 1978).…”

Oestrogen Treatment and Subsequent Pregnancy in Two Patients With Severe Hypergonadotrophic Ovarian Failure

“…Gonadal dysgenesis may thus be due to a rapid atresia rather than a congenital absence of germ cells in the gonads, but the cause of this atresia is unknown. Some quantitative effect may be acting, and therefore in rare cases, such as in our first case, some germ cells may remain in the ovaries, allowing the patient to have a transitory ovarian function and even to get pregnant (Bahner et al 1960;Grace et al 1973; Nakashima 8c Robinson 1971). Mosaicism is another possible explanation, but we found no evidence of mosaicism by study of five different tissues (Philip 8c Sele 1976).…”