Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis patients: A randomized, double-blind clinical trial

Silva-Santana, Nayara Cristina Freitas e; Rodrigues, Hellen Christina Neves; Martins, Tatiane Fagundes Pereira; Braga, Clarice Carneiro; Silva, Marina Alves Coelho; Cunha, Luíz Carlos da; Freitas, Ana Tereza Vaz de Souza; Costa, Nara Aline; Peixoto, Maria do Rosário Gondim

doi:10.1016/j.freeradbiomed.2022.11.008

Cited by 9 publications

(7 citation statements)

References 59 publications

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“…The amount of adsorbed curcumin seems to be greater for the colloidal suspension than both the combination with piperine and the phytosome formulation, while no differences have been observed between piperine-curcumin preparation and turmeric dry extract. In an RCT [ 73 ], the co-administration of the two molecules resulted in an improvement of oxidative stress and inflammation in hemodialysis patients (HD).…”

Section: Discussionmentioning

confidence: 99%

Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness

Servida

Panzeri

Tomaino

et al. 2023

IJMS

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The hypoglycemic properties of curcumin supplements in therapeutic doses are well-known and may represent a useful tool for the treatment of chronic diseases such as metabolic syndrome, insulin resistance and type 2 diabetes. The poor bioavailability of curcumin can be improved with the concomitant administration of piperine, with no severe adverse effects on glycemia reported so far in the literature. In this article, we further discuss a previously reported case of a helicopter pilot, affected by grade I obesity who, under curcumin and piperine treatment, experienced a transient loss of consciousness (TLOC), during a low-altitude flight. This episode led to a diagnosis of insulinoma, previously asymptomatic. We hypothesized that the combined effects of curcumin and piperine might have caused a severe hypoglycemic episode and subsequent TLOC. Therefore, further studies should be conducted to evaluate the safety of curcumin and piperine supplementation in subjects with impaired glucose metabolism and insulin secretion.

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Section: Discussionmentioning

confidence: 99%

Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness

Servida

Panzeri

Tomaino

et al. 2023

IJMS

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“…In the correlation analysis of metabolites with age, we observed eight major differential metabolites that were positively correlated with age and two that were negatively correlated with age. Piperine is a potent antioxidant with the ability to reduce oxidative stress and in ammation [20] . Animal experiments in rats have shown that piperine has neuroprotective effects, delaying cerebellar atrophy during aging and signi cantly improving memory [21] .…”

Section: Discussionmentioning

confidence: 99%

Gender - and age-related differences in plasma metabolic fingerprinting of healthy populations

Xie,

Tao,

et al. 2023

Preprint

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Background/Aims: The objective of this study was to investigate potential differences in the plasma metabolic fingerprinting of healthy individuals based on sex and age. Methods: Blood specimens were collected from patients at the First Affiliated Hospital of Nanchang University for health check-ups. The specimens were randomly divided into discovery and validation groups, maintaining a 1:1 ratio. Small molecule metabolites in each sample were detected using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). Results: Plasma metabolites exhibited significant variations between sexes and age groups in our population. A comparison between men and women revealed 13 differential metabolites, with acetylcholine having the highest differential expression (AUC = 0.909). A diagnostic model (model 1) combining PC 36:4, acetylcholine, L-threonine, and arginine showed an AUC value of 0.973, a sensitivity of 91%, and a specificity of 94%. Model 2, which combined creatinine, L-methionine, acetylcholine, and L-tyrosine, had an AUC value of 0.955, a sensitivity of 94%, and a specificity of 88%. When comparing age groups, the OPLSDA model exhibited moderate stability and higher predictive efficacy in the 18-44 and 45-67 age groups. The differential metabolites were predominantly lipid molecules, with the highest AUC found in Dehydroisoandrosterone-3-sulfate. Additionally, we observed that LysoPC 20:1, LysoPC 20:0, PI 38:5, PC 40:3, 3-Hydroxydodecanoic acid 12:0(3-OH), Choline, N-Formyl-L-methionine, and Homocystine positively correlated with age, while Dehydroisoandrosterone-3-sulfate and Piperine were negatively correlated with age. Conclusion: These differential metabolites provide insights for the prevention and treatment of age- and gender-related diseases.

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“…Activating NF-B activates proinflammatory genes such as cytokines (interleukins and tumour necrosis factor), adhesion molecules, and enzymes like Cyclooxygenase 2, and induces nitric oxide synthase (iNOS) 33 . Oxidative stress produces excess reactive oxygen species (ROS) and activates genes in inflammatory pathways that damage cellular molecules 34 . Nayara Cristina Freitas e Silva-Santana et al, (2022 studied the effect of turmeric supplementation with piperine in a randomised, double-blinded clinical trial conducted on haemophilia patients of the age group 20-75 years.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…Nayara Cristina Freitas e Silva-Santana et al, (2022 studied the effect of turmeric supplementation with piperine in a randomised, double-blinded clinical trial conducted on haemophilia patients of the age group 20-75 years. Piperine acts as a bioavailability enhancer of turmeric and is found to show superior antioxidant activity in comparison to turmeric 34 .…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Black Pepper, Dietary Photochemicals in the Prevention of Diseases by Oxidative Stress (A-Review)

Noel,

et al. 2023

Orient. J. Chem

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Medicinal plants are widely valued and are of prime concern globally. Scientific exploration on the flora and fauna of the globe increased, identifying drawbacks in synthetic utility of drugs like poor absorption, high dose, low bioavailability, and poor patient compliance. Plant based pharmaceuticals are considered as an alternative therapy and phytochemicals are being approved as drugs. Our interest is to explore on the spice, Black pepper which is classified under safe herb by FDA. The literature studies are collected estimating the efficacy of the spice against a variety of disease conditions like asthma, diabetes, hyperlipidaemia, inflammation, cancer, oxidative stress, gastrointestinal secretion, lipid metabolism, etc. In this review, we focussed on the scavenging capacity of black pepper in the abduction of free radicals. Increased in the production of free radicals is linked to causing oxidative stress in the body which is underlying cause for many lifestyle disorders like obesity, diabetes, congestive heart failure, myocardial ischemia, and different forms of cancer such as breast, prostate, lung, endometrial, skin, stomach, etc. This review focuses on the efficacy of black pepper and its relationship with many diseases.

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Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis patients: A randomized, double-blind clinical trial

Cited by 9 publications

References 59 publications

Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness

Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness

Gender - and age-related differences in plasma metabolic fingerprinting of healthy populations

Black Pepper, Dietary Photochemicals in the Prevention of Diseases by Oxidative Stress (A-Review)

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