Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series

Kalluru, Hindu; Kondaveeti, Satish Srinivas; Telapolu, Srivani; Kalachaveedu, Mangathayaru

doi:10.1016/j.ctcp.2020.101247

Cited by 14 publications

(3 citation statements)

References 29 publications

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“…We have recently reported on the beneficial modulation of turmeric supplementation on the QoL of breast cancer patients on paclitaxel monotherapy (Kalluru, Kondaveeti, Telapolu, & Kalachaveedu, 2020). Turmeric devoid of curcumin/curcuminoids is also attributed with antiinflammatory, antioxidant, and anticancer properties (Aggarwal, Yuan, Li, & Gupta, 2013; Prasad & Aggarwal, 2011).…”

Section: Methodsmentioning

confidence: 99%

Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review)

Kalachaveedu

Senthil

Azhagiyamanavalan

et al. 2023

Phytotherapy Research

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Emerging evidence on molecular biology related to tumors, inflammation, and immunity, highlights their architectural commonality shifting cancer treatment paradigms toward more economical prevention than treatment. Statistical surveys reveal exponentially growing herbal drug supplementation in cancer worldwide as vast pre‐clinical and clinical data unravel their multi‐mechanistic pharmacology. The integrative oncological approach calls for more “holistic” principles to be amalgamated into cancer care. New cancer drug development from herbs need not be limited by the archetypal ‘RCT‐Standardization’ bottlenecks. Based on comprehensive literature scoping as per Prisma‐ScR guidelines, we herein concurrently reviewed evidence‐based research reports of selected Indian Traditional Medicine (ITM) herbs of anticancer repute in parallel with their holistic therapeutics; a rationalistic exploration of ITM's scientific genre. Their synergy effect on cancer revisited using a trans‐pharmacological approach validates ITM's seemingly simplistic health/disease equation model, showing a fresh new avenue for re‐purposing whole herbal drug complexes in cancer management. Herbal drugs as per ITM are natural matrices whose dynamics of interaction in the etiopathology of cancer are conceptually and mechanistically integrative. Lateral perspective to the same as laid out in this review holds the key to their effectual development as more tangible cancer chemopreventives/new drug targets/leads if not as new pharmacological tools.

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Section: Methodsmentioning

confidence: 99%

Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review)

Kalachaveedu

Senthil

Azhagiyamanavalan

et al. 2023

Phytotherapy Research

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“…With its anti-inflammatory effects, it has been used in autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis [56]. In terms of drug interactions, turmeric supplementation of paclitaxel chemotherapy was found to improve the quality of life and pain scores in breast cancer patients [57].…”

Section: Turmericmentioning

confidence: 99%

Herbal Medicine for Pain Management: Efficacy and Drug Interactions

et al. 2021

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Complementary and alternative medicines such as herbal medicines are not currently part of the conventional medical system. As the popularity of and global market for herbal medicine grows among all age groups, with supporting scientific data and clinical trials, specific alternative treatments such as herbal medicine can be reclassified as a practice of conventional medicine. One of the most common conditions for which adults use herbal medicine is pain. However, herbal medicines carry safety concerns and may impact the efficacy of conventional therapies. Unfortunately, mechanisms of action are poorly understood, and their use is unregulated and often underreported to medical professionals. This review aims to compile common and available herbal medicines which can be used as an alternative to or in combination with conventional pain management approaches. Efficacy and safety are assessed through clinical studies on pain relief. Ensuing herb–drug interactions such as cytochrome modulation, additive and synergistic effects, and contraindications are discussed. While self-management has been recognized as part of the overall treatment strategy for patients suffering from chronic pain, it is important for practitioners to be able to also optimize and integrate herbal medicine and, if warranted, other complementary and alternative medicines into their care.

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“…Turmeric with its potential antiinflammatory and antioxidant properties exhibits multipronged anticancer activity—inhibits cellular proliferation, differentiation, and progression by altering key signaling molecules enhancing apoptotic death (Kim, Gupta, Park, Yadav, & Aggarwal, 2012). Turmeric is also reported to reduce oxidative damage (Ghalaut et al, 2012) and improve blood counts related to cancer treatment (Kalluru, Kondaveeti, Telapolu, & Kalachaveedu, 2020). With the increase in awareness about the health benefits of turmeric among the public, it is no coincidence that turmeric is one of the most used herbal supplements among cancer patients (Yin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients: A study with population pharmacokinetics approach

Kalluru

Mallayasamy

Kondaveeti

et al. 2022

Phytotherapy Research

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Turmeric is one of the most used herbal supplements among cancer patients. It reportedly modulates the function of CYP450 enzymes and drug transporters. This study investigates the effect of turmeric on the pharmacokinetics of paclitaxel in breast cancer patients. This is a prospective longitudinal study with 60 breast cancer patients on treatment with single-agent paclitaxel and turmeric. The patients were followed up for two consecutive chemotherapy cycles, and their blood samples were collected, first without turmeric (first cycle) and the next after a 21-day concomitant administration of 2 g/day turmeric (second cycle). Plasma samples were quantified for paclitaxel concentration using High Performance Liquid Chromatograph with UV detector (HPLC-UV) method. The sparse concentration-time data of paclitaxel were subjected to population pharmacokinetic modeling, and then noncompartmental analysis (NCA) was performed on the simulated data to estimate the pharmacokinetic parameters of paclitaxel, before and after turmeric supplementation, for comparisons.The population pharmacokinetic parameters of paclitaxel differed from before to after turmeric supplementation. NCA of simulated concentration-time profiles showed a statistically significant reduction of 7.7% and 12.1% in AUC inf and Cmax, respectively. Given the small magnitude of the changes in pharmacokinetic parameters, the observed changes are not clinically relevant. Thereby, turmeric at the recommended dose can be combined safely with paclitaxel.

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Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series

Cited by 14 publications

References 29 publications

Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review)

Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review)

Herbal Medicine for Pain Management: Efficacy and Drug Interactions

Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients: A study with population pharmacokinetics approach

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