Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

“…The present results demonstrated that PSII and CUR had synergic anti‐cancer effects on lung cancer cells (Figures and ). As our previous report, CUR promoted the absorption of RPS and thereby increased its anti‐tumour effect . In this experiment, it also proved that the main compound of RPS, PSII combined with CUR promoted both of their cellular uptake and possibly enhanced their bioavailability.…”

“…11 Interestingly in our previous research, CUR not only alleviated the toxicity and gastric stimulus induced by RPS, 12 but also improved the quality life of mice bearing tumour cells and enhanced their anticancer effect. 13,14 With the widely application of complex mixtures in clinic, the aim of this study was to investigate the synergistic anticancer effects of PSII and CUR in lung cancer cell lines. Taken together, these findings would provide the foundation for the use of CUR and RPS in future.…”

“…Combination of RPS and CUR not only alleviated the toxicity and gastric stimulus induced by RPS, 12 but also improved the quality life of mice bearing tumour cells and enhanced their anti-cancer effect. 13,14 In our previous research, PSII (formosanin C) as one of the main effective compounds in RPS 15 was absorbed in rat plasma after oral administration of RPS. 16 Meanwhile, the anti-tumour effect of PSII has been observed in several cultural cells and animal systems through inducing apoptosis, 2 promoting S phase arrest 3 and suppressing NF-κB signalling.…”

“…Rhizoma paridis saponins (RPS) played a good anti‐tumour role in many clinical applications. Combination of RPS and CUR not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumour cells and enhanced their anti‐cancer effect . In our previous research, PSII (formosanin C) as one of the main effective compounds in RPS was absorbed in rat plasma after oral administration of RPS .…”

A novel antitumor compound nobiliside D isolated from sea cucumber (Holothuria nobilis Selenka)

“…The novel compound was identified as the saponin family member nobiliside D. This extraction method achieves simultaneous extraction from H. nobilis Selenka, as well as improving the extraction efficiency and shortening the time of purification. Saponins are established to have anti-tumor activity (13,14). Saponins are the main metabolites of sea cucumber (5,6) and currently >10 types of saponin have been isolated and purified (15,16).…”