Turmeric Curcuminoid Polyphenolics as Antioxidant and Anticarcinogenic Agents

Tokuşoğlu, Özlem; Simsek, Alkan; Parvizi, Murtaza; Eymen, Dilvin

doi:10.20863/nsd.50644

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Acute heat stress significantly increased plasma TBARS but had no significant effect on SOD and ferric/reducing antioxidant power (38). Other studies have also shown that systemic increases in oxidative stress markers are likely dependent on the type of stress (39, 40).…”

Section: Resultsmentioning

confidence: 95%

Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model

et al. 2019

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Intestinal health is essential for feed efficiency and growth in animal agriculture and is dependent on barrier function, inflammation and dysbiosis. Our laboratory has published a nutritional model to induce gut inflammation using rye as a source of energy in poultry. More recently, we have used this model as an assessment of a nutritional rehabilitation model for better understanding of childhood undernutrition. The objective of this brief research report was to use a well-establish malabsorption model in broiler chickens using corn and rye as an energy source to identify several intestinal health biomarkers in the serum. To screen for inflammatory biomarkers, seven commercially available tests were used including Griess, superoxide dismutase, thiobarbituric acid reactive substances, Total antioxidant capacity, extracellular-signal-regulated kinase, Citrulline, and Interferon-ɤ; total IgA from cloacal swab was also measured. In the present study, chickens fed rye had a significant ( P < 0.05) reduction in body weight and body weight gain at 10 day when compared with chickens that received the corn diet. In the second phase of the experiment, chickens that remain with the corn diet had significant differences in body weight and body weight gain. No significant differences were observed for any of the four antioxidant biomarkers evaluated in the sera ( P > 0.05). However, significant differences were observed in serum citrulline and IFN-ɤ, as well as in cloacal IgA, in broiler chickens fed with rye, suggesting their potential use as biomarkers to study intestinal inflammation.

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Section: Resultsmentioning

confidence: 95%

Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model

et al. 2019

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“…The formation of these complexes could have been favoured by the acidic microenvironment present in the compartment that simulated the crop and an oxalate source that could have come from the feed (Tokusoglu et al . ). CUR forms stable complexes with almost all the metals and nonmetals.…”

Section: Discussionmentioning

confidence: 97%

“…This could indicate that there was a synergistic effect between BA and CUR due to the possible formation of rosocyanine and rubrocurcumin, which are very stable complexes (Halim et al 2012;Wanninger et al 2015). The formation of these complexes could have been favoured by the acidic microenvironment present in the compartment that simulated the crop and an oxalate source that could have come from the feed (Tokusoglu et al 2015). CUR forms stable complexes with almost all the metals and nonmetals.…”

Section: Discussionmentioning

confidence: 99%

Comparison of PrestoBlue^® and plating method to evaluate antimicrobial activity of ascorbic acid, boric acid and curcumin in an in vitro gastrointestinal model

et al. 2018

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“…CR is well known to exhibit a strong antioxidant activity, as evidenced by previous in vitro and in vivo studies [35, 88–92], which correlate with its anticancer and chemo-preventive actions [93]. Thus, it is anticipated that hybridization of CR with rGO-AuNP nanocomposite will yield superior anti-oxidant potential.…”

Section: Resultsmentioning

confidence: 95%

Hybrid nanocomposite curcumin-capped gold nanoparticle-reduced graphene oxide: Anti-oxidant potency and selective cancer cytotoxicity

et al. 2019

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Nanotechnology-based antioxidants and therapeutic agents are believed to be the next generation tools to face the ever-increasing cancer mortality rates. Graphene stands as a preferred nano-therapeutic template, due to the advanced properties and cellular interaction mechanisms. Nevertheless, majority of graphene-based composites suffer from hindered development as efficient cancer therapeutics. Recent nano-toxicology reviews and recommendations emphasize on the preliminary synthetic stages as a crucial element in driving successful applications results. In this study, we present an integrated, green, one-pot hybridization of target-suited raw materials into curcumin-capped gold nanoparticle-conjugated reduced graphene oxide (CAG) nanocomposite, as a prominent anti-oxidant and anti-cancer agent. Distinct from previous studies, the beneficial attributes of curcumin are employed to their fullest extent, such that they perform dual roles of being a natural reducing agent and possessing antioxidant anti-cancer functional moiety. The proposed novel green synthesis approach secured an enhanced structure with dispersed homogenous AuNPs (15.62 ± 4.04 nm) anchored on reduced graphene oxide (rGO) sheets, as evidenced by transmission electron microscopy, surpassing other traditional chemical reductants. On the other hand, safe, non-toxic CAG elevates biological activity and supports biocompatibility. Free radical DPPH inhibition assay revealed CAG antioxidant potential with IC 50 (324.1 ± 1.8%) value reduced by half compared to that of traditional citrate-rGO-AuNP nanocomposite (612.1 ± 10.1%), which confirms the amplified multi-potent antioxidant activity. Human colon cancer cell lines (HT-29 and SW-948) showed concentration- and time-dependent cytotoxicity for CAG, as determined by optical microscopy images and WST-8 assay, with relatively low IC 50 values (~100 μg/ml), while preserving biocompatibility towards normal human colon (CCD-841) and liver cells (WRL-68), with high selectivity indices (≥ 2.0) at all tested time points. Collectively, our results demonstrate effective green synthesis of CAG nanocomposite, free of additional stabilizing agents, and its bioactivity as an antioxidant and selective anti-colon cancer agent.

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Turmeric Curcuminoid Polyphenolics as Antioxidant and Anticarcinogenic Agents

Cited by 8 publications

References 15 publications

Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model

Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model

Comparison of PrestoBlue^® and plating method to evaluate antimicrobial activity of ascorbic acid, boric acid and curcumin in an in vitro gastrointestinal model

Hybrid nanocomposite curcumin-capped gold nanoparticle-reduced graphene oxide: Anti-oxidant potency and selective cancer cytotoxicity

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Turmeric Curcuminoid Polyphenolics as Antioxidant and Anticarcinogenic Agents

Cited by 8 publications

References 15 publications

Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model

Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model

Comparison of PrestoBlue® and plating method to evaluate antimicrobial activity of ascorbic acid, boric acid and curcumin in an in vitro gastrointestinal model

Hybrid nanocomposite curcumin-capped gold nanoparticle-reduced graphene oxide: Anti-oxidant potency and selective cancer cytotoxicity

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Product

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Comparison of PrestoBlue^® and plating method to evaluate antimicrobial activity of ascorbic acid, boric acid and curcumin in an in vitro gastrointestinal model