Turmeric-Associated Drug-Induced Liver Injury

Houlihan, Conor; Reynolds, Brandon; Kjerengtroen, Sara; Murry, Daryl J.; Khoury, Nathalie

doi:10.14309/crj.0000000000000941

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…The authors reported the cases had RUCAM scores of 7 and 6, respectively. Another recent turmeric and piperine supplement-induced liver injury case was reported in a 49-year-old woman admitted with elevated aspartate aminotransferase and alanine aminotransferase with no history of liver disease [43]. The authors sent the supplement for mass spectrometry analysis, which confirmed the curcumin component, albeit less than the label-reported amount.…”

Section: Turmeric/curcuminmentioning

confidence: 91%

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues,

Cundra,

Alhaqqan

et al. 2024

Livers

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Herbal-induced liver injury (HILI) continues to increase in prevalence each year due to the ongoing popularity of herbal supplements and complementary and alternative medicines. A detailed literature review of case reports and clinical studies published from March 2021 to March 2023 was performed. We discuss the epidemiology and diagnosis of HILI as well as the current and proposed laws and regulations. The 2021 ACG guidelines and 2022 AASLD practice guidelines for the diagnosis and management of drug and herbal-induced liver injury are discussed. We describe updates to previously reported etiologies of HILI such as ayurveda, ashwagandha, turmeric, kratom, green tea extract, and garcinia cambogia. Newly described supplements resulting in HILI, such as tinospora cordifolia, horse chestnut, alkaline water, and more, are described. We discuss newly and previously identified hepatoprotective herbal supplements as they have been reported in the study of animal models and human liver cells. This review suggests the need for ongoing research on the causes and mechanisms of HILI to ensure its proper diagnosis, prevention, and treatment in the future. The goal of this review is to provide novice and expert readers with knowledge regarding the possible etiologies of HILI and a general overview.

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Section: Turmeric/curcuminmentioning

confidence: 91%